Protein Alignment Npc1a and Ptchd3

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: NP_083325.1
• Gene: Ptchd3 / 74675
• MGIID: 1921925
• Length: 906
• Species: Mus musculus
• Alignment Length: 987
• Identity: 222/987 - (22%)
• Similarity: 422/987 - (42%)
• Gaps: 213/987 - (21%)

  Fly   333 HT---ETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLE 394
            ||   |..|...|.::|....:||.|.|:..|.|...||.|:.|:            |..|..||
Mouse    72 HTNCLEAPLSRGFQRFGATVGANPWLFLLGPALLTASLGTGLIFL------------PKEKENLE 124

  Fly   395 REFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTF--------------------GPVFDRE 439
            .::  |......:.|:..::.       |.::|..|.|                    ..:.:.|
Mouse   125 EQY--TPIGSPAKAERRFVQG-------HFSTNDTYRFSASRTSSETNFASILVVSLANSLLEPE 180

  Fly   440 FLTKVLDLQEGI---KEINANGTQL--KDIC--YAPLSDDGSEIDVSQCVVQSIWGYFGDDRERL 497
            ...:|..|.:.:   |.:..||||:  :::|  |..|           ||         .....|
Mouse   181 IFKEVSKLDQAVQALKVVQENGTQILYQEVCAKYKTL-----------CV---------PPNPLL 225

  Fly   498 DDHDEDNGFNVTYLDALYDCISNP----YLCLAPYGGPVDPAIALGGFLPPGDQLTG-STKFELA 557
            .....::..|::  |..:...:.|    ||. ..:||.|     ||       |:|| |.:...:
Mouse   226 FSWQHNSSLNLS--DLTFPIHNTPTQLIYLA-GFFGGNV-----LG-------QMTGKSQRLVES 275

  Fly   558 NAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSD 622
            .|:.|.:.:|. .:..|.|.:..|...|::...:...:...:.:::.:.|..|.:.|....|::.
Mouse   276 RAMRLLYYLKT-EDPEDSERSQAWLTHFLDHFNDMKSSLTLEEIEVVYFSSLSRQLEFEATSKTV 339

  Fly   623 VLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLI 687
            :....::|:::.::..:|...:.     .|.:|:.:.:.||..|..||||..|:..::|:| .:|
Mouse   340 IPLFHLAYILIILFAVVSCSRLD-----CIRNKMCVAVFGVFSVAMSVVSGFGLMLHLGVP-FVI 398

  Fly   688 IVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGG 752
            ||...|||:|.||||::||::...|:...  :|::.:::.....||..|:.:|:::....|:.|.
Mouse   399 IVANSPFLILGVGVDDMFIMISAWQKTSL--SESIRERLSNSYSKVAVSITITTITNVLAFYTGI 461

  Fly   753 LSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKR-------------REENRMDICCFIK 804
            .|...:|:.|.:|.|..|:..:...||||.::..||.||             :..:....||...
Mouse   462 TSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKREVAWSRWLEKPDQKYSSLKKSCCVPF 526

  Fly   805 GKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQ 869
            |...|....:...:..||...:.|||.....:..|::::..::..||....::..|||.......
Mouse   527 GSLIDKHGEDNHPMNLFFRDYFGPFLTTSKAKFIVVLLYIFYIISSIYGCFQVQEGLDLRNLASD 591

  Fly   870 DSFVLHYFQSLNENL--NIGPPVYFVLKGDLAY-TNSSDQNLVCAGQYCNDDSVLTQIYLASRHS 931
            ||::..|| ::.|:.  :.||.|..::...:.| .|...|.|         |..:||.      .
Mouse   592 DSYITPYF-NVEEDYFSDYGPRVMVIVTESVNYWDNDVRQKL---------DKCMTQF------E 640

  Fly   932 NQTYIARPASS-WIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKE--- 992
            ...|:.:..:. |::.|.          :|...||:                    .|.:|.
Mouse   641 ENEYVDKNLTEFWLEAYM----------QYMNSSGN--------------------NPNDKNTFM 675

  Fly   993 -----FVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFL 1052
                 |:::.|.|..|                 :..|:|:|               :.||..:..
Mouse   676 NNIAGFLQFFPIFTYD-----------------INISSSNE---------------ITSSRGFIQ 708

  Fly  1053 ALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLS 1117
            .::.:.  |:|..:||. :|.|    :|....|.:..|:..:::::||..:..:|::::.|:..:
Mouse   709 IVDVSS--SSNKKRMLL-KLRS----IAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTA 766

  Fly  1118 IFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVH 1182
            :|:|:.:|:...|.| |.|...|..::|.:.|.|.:||::|:::|::|||:.:|.|.:|.:|:.:
Mouse   767 MFIVSLLLIPHPVCS-LWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISY 830

  Fly  1183 SFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAA 1247
            :|.:|...|...::.::|..:|..:... .::...|:.||:.||:.||:.|:..|:| ::..|||
Mouse   831 AFVSSTEPSVNKKSIEALYLLGYPVLQS-AISTIIGVCVLSAAKAYIFRTFFKIMFL-VMFFGAA 893

  Fly  1248 HGLIFLPVLLSY 1259
            |||||:||.|::
Mouse   894 HGLIFIPVFLTF 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	222/987 (22%)
Ptchd3	NP_083325.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70
		Patched	127..906	CDD:308203	202/920 (22%)