Protein Alignment Npc1a and npc1

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: XP_005163715.1
• Gene: npc1 / 553330
• ZFINID: ZDB-GENE-030131-3161
• Length: 1277
• Species: Danio rerio
• Alignment Length: 1293
• Identity: 572/1293 - (44%)
• Similarity: 804/1293 - (62%)
• Gaps: 92/1293 - (7%)

  Fly    16 ILIAAVLFTLIQSSKQDCVWYGVC--NTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENS 78
            :|:|.||.:..... |.|:|||.|  :.|......||.|.|.|..:..:|.|||::.|..|: .:
Zfish    12 LLLATVLLSHWVHG-QHCIWYGECGNSPNVPEKKLNCNYTGPAVPLPNEGQELLQELCPRLV-YA 74

  Fly    79 ENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDE 143
            :|:.|||..|:..|..|:::....|.|||:|..|.:...|:.||||:|::|:.|....| :|...
Zfish    75 DNRVCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISVKDFLK-EKNQT 138

  Fly   144 YISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPF 208
            .:.:|..:|:..:.:..:.:|..|..|.:...|..|:||. .||.|.|..|..:|...:|..|||
Zfish   139 SVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGR-DASVCTPQIWIQYMFSISNGQVPF 202

  Fly   209 QITYIQHEPKSNS---NNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIV 270
            .|     ||....   ...||:|..|..|:|::......|||.||...|...|..||.|.|:.|:
Zfish   203 GI-----EPIFTDVPVQGMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIIL 262

  Fly   271 GLDAYFVIMAAVFLVGVLVF---LMGSFLFTQ-------GSSMDDN----FQVDGNDVSDEMPYS 321
            ||||...||...::..:|:|   ::|::.:.:       |..:|.|    ...||.|:.||.
Zfish   263 GLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHSLNSDGTDLIDEA--- 324

  Fly   322 ENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWAS 386
               |..|.:|...|..|...|::||:.....|...:::...|:.|...|::::.|||:||:||::
Zfish   325 ---SCCETVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSA 386

  Fly   387 PNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGP-YTFGPVFDREFLTKVLDLQEG 450
            |:|::|.|:.:||..|.||:|.||:||......:...:|..|. ..|.|:.:...|.:|||||..
Zfish   387 PSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGGFSTITGDIIPFSPILNLSLLHQVLDLQLE 451

  Fly   451 IK----EINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGF--NVT 509
            |:    |.......|||||.:|||...     ..|.:.|:..||.:..|.||...:|..|  |..
Zfish   452 IENLIAEYKGENVTLKDICVSPLSPYN-----DNCTILSVLNYFQNSHEVLDHEFQDEFFLYNDY 511

  Fly   510 YLDALYDCISNPYL----------CLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTF 564
            :...|| |.|:|..          |:..:||||.|.:.|||:        ..:.:..|.|:::||
Zfish   512 HTHLLY-CASSPTSLDDTSRLHDPCMGTFGGPVFPWLVLGGY--------EDSAYNNATALVITF 567

  Fly   565 LVKNHHNKTD-LENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILV 628
            .|.|:.|.|: |..||.|||:|:.||.||...|::    ::|:||||||||::|||.|||.||::
Zfish   568 PVTNYLNDTEKLGKALAWEKEFIRFMKNYENPNLT----VSFSSERSIEDEIDRESNSDVSTIVI 628

  Fly   629 SYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIP 693
            ||:|||:||:::||.:...:.:.:||||:|||.|::|||:||..|:|:|.|||:|.|||::||||
Zfish   629 SYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIP 693

  Fly   694 FLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPA 758
            |||||||||||||:|||:|||:|.|.|.|.||:|||||.|.|||.|:|.||:..||||.||.|||
Zfish   694 FLVLAVGVDNIFIIVQTYQRDERMPEEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPA 758

  Fly   759 VRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIK---GKKPDSITSNEGLLYK 820
            ||.|:|:||:|:.|||||||:|||||..||.||:|.|||||.|.:|   |::..|    ||.|::
Zfish   759 VRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQEEKS----EGWLFR 819

  Fly   821 FFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLN 885
            ||..:|.||::|..||..|:.:|...|.||||:..:::|||:|.|:||.||:||:||.:|::.|:
Zfish   820 FFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLH 884

  Fly   886 IGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDW 950
            .|||||||::....|.....||.||.|..||:||::.|||.||..||.|.|:...|||:||||||
Zfish   885 TGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTASLMSNYTRISNVPSSWLDDYFDW 949

  Fly   951 AAAASSCCKYRKDSGDFCPHQ--DTSCLRCN-ITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKA 1012
            ....|:||:|...:|.||...  |.||:.|. :|.:...||...||:.:||.||.|||:..|.|.
Zfish   950 VKPQSTCCRYYNSTGAFCNASVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKG 1014

  Fly  1013 GHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGV 1077
            ||||||.||...:::  .::.|:|||:||||||:|:|:..|::.||:::.||||.|.....|
Zfish  1015 GHAAYGTAVDLKDNN--TDVGATYFMSYHTILKNSSDFINAMKMARELTDNITQTLSTHDKS--- 1074

  Fly  1078 PMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITM 1142
                   .:||||||||||||||||:..||..::|:|:.:||:||.||:||::.||::|..||.|
Zfish  1075 -------YKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAM 1132

  Fly  1143 IVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSI 1207
            |::|:.|:|:.|:|||||||||||||:.|||||||||:|.:|:.|...|:::||.::|:.||||:
Zfish  1133 ILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSV 1197

  Fly  1208 FSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVS 1265
            |||||||||.|||:||.:||||||:|||||||.||::|||||||||||||||.|..:|
Zfish  1198 FSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAGKSLS 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	565/1270 (44%)
npc1	XP_005163715.1	2A060601	28..1251	CDD:273337	565/1270 (44%)