DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1a and npc1

DIOPT Version :9

Sequence 1:	NP_001188769.1	Gene:	Npc1a / 34358	FlyBaseID:	FBgn0024320	Length:	1287	Species:	Drosophila melanogaster
Sequence 2:	XP_005163715.1	Gene:	npc1 / 553330	ZFINID:	ZDB-GENE-030131-3161	Length:	1277	Species:	Danio rerio

Alignment Length:	1293	Identity:	572/1293 - (44%)
Similarity:	804/1293 - (62%)	Gaps:	92/1293 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ILIAAVLFTLIQSSKQDCVWYGVC--NTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENS 78
            :|:|.||.:..... |.|:|||.|  :.|......||.|.|.|..:..:|.|||::.|..|: .:
Zfish    12 LLLATVLLSHWVHG-QHCIWYGECGNSPNVPEKKLNCNYTGPAVPLPNEGQELLQELCPRLV-YA 74

  Fly    79 ENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDE 143
            :|:.|||..|:..|..|:::....|.|||:|..|.:...|:.||||:|::|:.|....| :|...
Zfish    75 DNRVCCDTQQLNTLKSNIQIPLQYLSRCPACFFNFMTLFCELTCSPRQSQFISVKDFLK-EKNQT 138

  Fly   144 YISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPF 208
            .:.:|..:|:..:.:..:.:|..|..|.:...|..|:||. .||.|.|..|..:|...:|..|||
Zfish   139 SVGNVTYYITQTFADAMFNACRDVQAPSSNIKALGLLCGR-DASVCTPQIWIQYMFSISNGQVPF 202

  Fly   209 QITYIQHEPKSNS---NNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIV 270
            .|     ||....   ...||:|..|..|:|::......|||.||...|...|..||.|.|:.|:
Zfish   203 GI-----EPIFTDVPVQGMTPMNNRTFNCSQSLDDGSEPCSCQDCSEVCGPTPVPPPIPPPWIIL 262

  Fly   271 GLDAYFVIMAAVFLVGVLVF---LMGSFLFTQ-------GSSMDDN----FQVDGNDVSDEMPYS 321
            ||||...||...::..:|:|   ::|::.:.:       |..:|.|    ...||.|:.||.
Zfish   263 GLDAMSFIMWCSYIAFLLIFFGVVLGAWCYRRSVVTSEYGPILDSNQPHSLNSDGTDLIDEA--- 324

  Fly   322 ENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWAS 386
               |..|.:|...|..|...|::||:.....|...:::...|:.|...|::::.|||:||:||::
Zfish   325 ---SCCETVGERFENSLRLVFSRWGSLCVRQPLTIILSSLVLICICSAGLSYMRITTNPVELWSA 386

  Fly   387 PNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGP-YTFGPVFDREFLTKVLDLQEG 450
            |:|::|.|:.:||..|.||:|.||:||......:...:|..|. ..|.|:.:...|.:|||||..
Zfish   387 PSSRARQEKNYFDQHFGPFFRTEQLIITTPWTEEGGFSTITGDIIPFSPILNLSLLHQVLDLQLE 451

  Fly   451 IK----EINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGF--NVT 509
            |:    |.......|||||.:|||...     ..|.:.|:..||.:..|.||...:|..|  |..
Zfish   452 IENLIAEYKGENVTLKDICVSPLSPYN-----DNCTILSVLNYFQNSHEVLDHEFQDEFFLYNDY 511

  Fly   510 YLDALYDCISNPYL----------CLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTF 564
            :...|| |.|:|..          |:..:||||.|.:.|||:        ..:.:..|.|:::||
Zfish   512 HTHLLY-CASSPTSLDDTSRLHDPCMGTFGGPVFPWLVLGGY--------EDSAYNNATALVITF 567

  Fly   565 LVKNHHNKTD-LENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILV 628
            .|.|:.|.|: |..||.|||:|:.||.||...|::    ::|:||||||||::|||.|||.||::
Zfish   568 PVTNYLNDTEKLGKALAWEKEFIRFMKNYENPNLT----VSFSSERSIEDEIDRESNSDVSTIVI 628

  Fly   629 SYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIP 693
            ||:|||:||:::||.:...:.:.:||||:|||.|::|||:||..|:|:|.|||:|.|||::||||
Zfish   629 SYIIMFVYISVALGRINSCRTLLVDSKISLGIAGILIVLSSVACSLGIFSYIGIPLTLIVIEVIP 693

  Fly   694 FLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPA 758
            |||||||||||||:|||:|||:|.|.|.|.||:|||||.|.|||.|:|.||:..||||.||.|||
Zfish   694 FLVLAVGVDNIFIIVQTYQRDERMPEEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPA 758

  Fly   759 VRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIK---GKKPDSITSNEGLLYK 820
            ||.|:|:||:|:.|||||||:|||||..||.||:|.|||||.|.:|   |::..|    ||.|::
Zfish   759 VRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVKLSDGQEEKS----EGWLFR 819

  Fly   821 FFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLN 885
            ||..:|.||::|..||..|:.:|...|.||||:..:::|||:|.|:||.||:||:||.:|::.|:
Zfish   820 FFKKIYAPFILKDWVRPLVVAVFVGMLSFSIAVVNKVEIGLEQTLSMPDDSYVLNYFGNLSKYLH 884

  Fly   886 IGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDW 950
            .|||||||::....|.....||.||.|..||:||::.|||.||..||.|.|:...|||:||||||
Zfish   885 TGPPVYFVVEDGHDYKTFEGQNAVCGGVGCNNDSLVQQIYTASLMSNYTRISNVPSSWLDDYFDW 949

  Fly   951 AAAASSCCKYRKDSGDFCPHQ--DTSCLRCN-ITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKA 1012
            ....|:||:|...:|.||...  |.||:.|. :|.:...||...||:.:||.||.|||:..|.|.
Zfish   950 VKPQSTCCRYYNSTGAFCNASVVDKSCVHCRPMTSSGKQRPNGTEFMHFLPMFLSDNPNIKCGKG 1014

  Fly  1013 GHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGV 1077
            ||||||.||...:::  .::.|:|||:||||||:|:|:..|::.||:::.||||.|.....|
Zfish  1015 GHAAYGTAVDLKDNN--TDVGATYFMSYHTILKNSSDFINAMKMARELTDNITQTLSTHDKS--- 1074

  Fly  1078 PMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITM 1142
                   .:||||||||||||||||:..||..::|:|:.:||:||.||:||::.||::|..||.|
Zfish  1075 -------YKVFPYSVFYVFYEQYLTIVDDTALNLGVSLSAIFIVTAVLLGFELWSAVLVCFTIAM 1132

  Fly  1143 IVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSI 1207
            |::|:.|:|:.|:|||||||||||||:.|||||||||:|.:|:.|...|:::||.::|:.||||:
Zfish  1133 ILINMFGVMWLWSISLNAVSLVNLVMSCGISVEFCSHIVRAFSISTRSSRVERAEEALAHMGSSV 1197

  Fly  1208 FSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVS 1265
            |||||||||.|||:||.:||||||:|||||||.||::|||||||||||||||.|..:|
Zfish  1198 FSGITLTKFGGILILALSKSQIFQIFYFRMYLAIVLLGAAHGLIFLPVLLSYAGKSLS 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_001188769.1	NPC1_N	31..274	CDD:293023	83/247 (34%)
		2A060601	33..1261	CDD:273337	565/1270 (44%)
		Sterol-sensing	651..804	CDD:289145	104/152 (68%)
npc1	XP_005163715.1	NPC1_N	26..247	CDD:293023	74/228 (32%)
		2A060601	28..1251	CDD:273337	565/1270 (44%)
		Sterol-sensing	651..804	CDD:289145	104/152 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595384
Domainoid	1	1.000	242	1.000	Domainoid score	I2193
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H228
Inparanoid	1	1.050	1037	1.000	Inparanoid score	I265
OMA	1	1.010	-	-		QHG55095
OrthoDB	1	1.010	-	-		D31089at33208
OrthoFinder	1	1.000	-	-		FOG0001659
OrthoInspector	1	1.000	-	-		oto39911
orthoMCL	1	0.900	-	-		OOG6_101370
Panther	1	1.100	-	-	LDO	PTHR45727
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2210
SonicParanoid	1	1.000	-	-		X943
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800