Protein Alignment Npc1a and NPC1

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: XP_005258334.1
• Gene: NPC1 / 4864
• HGNCID: 7897
• Length: 1303
• Species: Homo sapiens
• Alignment Length: 1308
• Identity: 578/1308 - (44%)
• Similarity: 811/1308 - (62%)
• Gaps: 104/1308 - (7%)

  Fly    13 GVHILIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRC-GFLLE 76
            |:.:.:..:|....|...|.|||||.|.........||.|:|..|.:..||.:|:::.| ||...
Human     5 GLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFG 69

  Fly    77 NSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKG 141
            |.  ..|||..|::.|..|::|....|.|||||..||:...|:.||||:|::|::|.||
Human    70 NV--SLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTAT------ 126

  Fly   142 DEYISSV-----------DLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWF 195
            ::|:..|           ..::...:.|..|.:|..|..|.:...|..|:||. .|..||.|.|.
Human   127 EDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGK-DADACNATNWI 190

  Fly   196 NFMGDATNPYVPFQITYIQHE-PKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPP 259
            .:|.:..|...||.||.:..: |   .:...|:|..|..|:::|......|||.||.:.|...|.
Human   191 EYMFNKDNGQAPFTITPVFSDFP---VHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQ 252

  Fly   260 EPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSF----------LFTQGSSMDDN--FQVDGN 312
            .||.|.|:.|:||||.:|||...::..:||| .|:|          ..::.:.:|.|  |.|:.:
Human   253 PPPPPAPWTILGLDAMYVIMWITYMAFLLVF-FGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNAS 316

  Fly   313 D------VSDEMPYSE----NDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVIL 367
            |      ::...|.|.    ..|..:.:.|..|..|...||:||::...|||..:......:...
Human   317 DKGTAWLLTSTFPSSPVLPGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITAC 381

  Fly   368 GYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHN--TSNGPY 430
            ..|:.|:.:||:||.||::|:|::|||:|:||..|.||:|.||:||:|....:.::.  .|....
Human   382 SSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADV 446

  Fly   431 TFGPVFDREFLTKVLDLQEGIKEINA---NGT-QLKDICYAPLSDDGSEIDVSQCVVQSIWGYFG 491
            .|||..|.:.|.:|||||..|:.|.|   |.| .|:|||.||||...     :.|.:.|:..||.
Human   447 PFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYN-----TNCTILSVLNYFQ 506

  Fly   492 DDRERLDDHDEDNGFNVTYLD----ALYDCISNPYL----------CLAPYGGPVDPAIALGGFL 542
            :....||....|:.|  .|.|    .|| |:..|..          ||..:||||.|.:.|||:
Human   507 NSHSVLDHKKGDDFF--VYADYHTHFLY-CVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY- 567

  Fly   543 PPGDQLTGSTKFELANAIILTFLVKNHHNKTD-LENALTWEKKFVEFMTNYTKNNMSQYMDIAFT 606
              .||     .:..|.|:::||.|.|::|.|: |:.|..|||:|:.|:.||...|::    |:||
Human   568 --DDQ-----NYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT----ISFT 621

  Fly   607 SERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVV 671
            :||||||||||||.|||.|:::||.|||:||:::|||:|..:|:.:|||::|||.|::|||:||.
Human   622 AERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVA 686

  Fly   672 SSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPS 736
            .|:|||.|||||.|||::||||||||||||||||||||.:|||:|...|||:||:||:||:|.||
Human   687 CSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPS 751

  Fly   737 MLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICC 801
            |.|:|.||:..||||.||.||||..|:|:||:|:.|||||||||||||..||.||:|:||:||.|
Human   752 MFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFC 816

  Fly   802 FIKGKKP-DSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQEL 865
            .::|.:. .|:.::|..|::||.:.|.|.|:|..:|..|:.||...|.||||:..::||||||.|
Human   817 CVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSL 881

  Fly   866 AMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRH 930
            :||.||:::.||:|:::.|:.||||||||:....||:|..||:||.|..||:||::.||:.|::.
Human   882 SMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQL 946

  Fly   931 SNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQ--DTSCLRCN-ITKNSLLRPEEKE 992
            .|.|.|....||||||||||....||||:....:..||...  |.:|:||. :|.....||:..:
Human   947 DNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGD 1011

  Fly   993 FVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESA 1057
            |:::||.||.|||:..|.|.|||||..||.....| ...:.|:|||.|||:|::|||:..||:.|
Human  1012 FMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGH-GTRVGATYFMTYHTVLQTSADFIDALKKA 1075

  Fly  1058 RKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVT 1122
            |.|::|:|:.:       |:   :.....||||||||||||||||:..||:.::|:|:.:||:||
Human  1076 RLIASNVTETM-------GI---NGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVT 1130

  Fly  1123 FVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATS 1187
            .||:|.::.||:::..||.|::||:.|:|:.|.|||||||||||||:.|||||||||:..:|..|
Human  1131 MVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVS 1195

  Fly  1188 KSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIF 1252
            ...|:::||.::|:.||||:|||||||||.||:|||||||||||:|||||||.:|::||.|||||
Human  1196 MKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIF 1260

  Fly  1253 LPVLLSYI 1260
            ||||||||
Human  1261 LPVLLSYI 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	574/1288 (45%)
NPC1	XP_005258334.1	2A060601	25..1268	CDD:273337	572/1286 (44%)