DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and NPC1

DIOPT Version :9

Sequence 1:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:XP_005258334.1 Gene:NPC1 / 4864 HGNCID:7897 Length:1303 Species:Homo sapiens


Alignment Length:1308 Identity:578/1308 - (44%)
Similarity:811/1308 - (62%) Gaps:104/1308 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GVHILIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRC-GFLLE 76
            |:.:.:..:|....|...|.|||||.|.........||.|:|..|.:..||.:|:::.| ||...
Human     5 GLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFG 69

  Fly    77 NSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKG 141
            |.  ..|||..|::.|..|::|....|.|||||..||:...|:.||||:|::|::|.||      
Human    70 NV--SLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTAT------ 126

  Fly   142 DEYISSV-----------DLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWF 195
            ::|:..|           ..::...:.|..|.:|..|..|.:...|..|:||. .|..||.|.|.
Human   127 EDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGK-DADACNATNWI 190

  Fly   196 NFMGDATNPYVPFQITYIQHE-PKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPP 259
            .:|.:..|...||.||.:..: |   .:...|:|..|..|:::|......|||.||.:.|...|.
Human   191 EYMFNKDNGQAPFTITPVFSDFP---VHGMEPMNNATKGCDESVDEVTAPCSCQDCSIVCGPKPQ 252

  Fly   260 EPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLMGSF----------LFTQGSSMDDN--FQVDGN 312
            .||.|.|:.|:||||.:|||...::..:||| .|:|          ..::.:.:|.|  |.|:.:
Human   253 PPPPPAPWTILGLDAMYVIMWITYMAFLLVF-FGAFFAVWCYRKRYFVSEYTPIDSNIAFSVNAS 316

  Fly   313 D------VSDEMPYSE----NDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVIL 367
            |      ::...|.|.    ..|..:.:.|..|..|...||:||::...|||..:......:...
Human   317 DKGTAWLLTSTFPSSPVLPGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVFITAC 381

  Fly   368 GYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHN--TSNGPY 430
            ..|:.|:.:||:||.||::|:|::|||:|:||..|.||:|.||:||:|....:.::.  .|....
Human   382 SSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIYQPYPSGADV 446

  Fly   431 TFGPVFDREFLTKVLDLQEGIKEINA---NGT-QLKDICYAPLSDDGSEIDVSQCVVQSIWGYFG 491
            .|||..|.:.|.:|||||..|:.|.|   |.| .|:|||.||||...     :.|.:.|:..||.
Human   447 PFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYN-----TNCTILSVLNYFQ 506

  Fly   492 DDRERLDDHDEDNGFNVTYLD----ALYDCISNPYL----------CLAPYGGPVDPAIALGGFL 542
            :....||....|:.|  .|.|    .|| |:..|..          ||..:||||.|.:.|||: 
Human   507 NSHSVLDHKKGDDFF--VYADYHTHFLY-CVRAPASLNDTSLLHDPCLGTFGGPVFPWLVLGGY- 567

  Fly   543 PPGDQLTGSTKFELANAIILTFLVKNHHNKTD-LENALTWEKKFVEFMTNYTKNNMSQYMDIAFT 606
              .||     .:..|.|:::||.|.|::|.|: |:.|..|||:|:.|:.||...|::    |:||
Human   568 --DDQ-----NYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT----ISFT 621

  Fly   607 SERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVV 671
            :||||||||||||.|||.|:::||.|||:||:::|||:|..:|:.:|||::|||.|::|||:||.
Human   622 AERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHMKSCRRLLVDSKVSLGIAGILIVLSSVA 686

  Fly   672 SSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPS 736
            .|:|||.|||||.|||::||||||||||||||||||||.:|||:|...|||:||:||:||:|.||
Human   687 CSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPS 751

  Fly   737 MLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICC 801
            |.|:|.||:..||||.||.||||..|:|:||:|:.|||||||||||||..||.||:|:||:||.|
Human   752 MFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFC 816

  Fly   802 FIKGKKP-DSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQEL 865
            .::|.:. .|:.::|..|::||.:.|.|.|:|..:|..|:.||...|.||||:..::||||||.|
Human   817 CVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSL 881

  Fly   866 AMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRH 930
            :||.||:::.||:|:::.|:.||||||||:....||:|..||:||.|..||:||::.||:.|::.
Human   882 SMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQL 946

  Fly   931 SNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQ--DTSCLRCN-ITKNSLLRPEEKE 992
            .|.|.|....||||||||||....||||:....:..||...  |.:|:||. :|.....||:..:
Human   947 DNYTRIGFAPSSWIDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGD 1011

  Fly   993 FVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESA 1057
            |:::||.||.|||:..|.|.|||||..||.....| ...:.|:|||.|||:|::|||:..||:.|
Human  1012 FMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGH-GTRVGATYFMTYHTVLQTSADFIDALKKA 1075

  Fly  1058 RKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVT 1122
            |.|::|:|:.:       |:   :.....||||||||||||||||:..||:.::|:|:.:||:||
Human  1076 RLIASNVTETM-------GI---NGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVT 1130

  Fly  1123 FVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATS 1187
            .||:|.::.||:::..||.|::||:.|:|:.|.|||||||||||||:.|||||||||:..:|..|
Human  1131 MVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVS 1195

  Fly  1188 KSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIF 1252
            ...|:::||.::|:.||||:|||||||||.||:|||||||||||:|||||||.:|::||.|||||
Human  1196 MKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIF 1260

  Fly  1253 LPVLLSYI 1260
            ||||||||
Human  1261 LPVLLSYI 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023 86/255 (34%)
2A060601 33..1261 CDD:273337 574/1288 (45%)
Sterol-sensing 651..804 CDD:289145 103/152 (68%)
NPC1XP_005258334.1 NPC1_N 23..267 CDD:293023 86/255 (34%)
2A060601 25..1268 CDD:273337 572/1286 (44%)
Sterol-sensing 666..819 CDD:289145 103/152 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159264
Domainoid 1 1.000 236 1.000 Domainoid score I2355
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H228
Inparanoid 1 1.050 1061 1.000 Inparanoid score I256
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55095
OrthoDB 1 1.010 - - D31089at33208
OrthoFinder 1 1.000 - - FOG0001659
OrthoInspector 1 1.000 - - oto90483
orthoMCL 1 0.900 - - OOG6_101370
Panther 1 1.100 - - LDO PTHR45727
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2210
SonicParanoid 1 1.000 - - X943
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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