DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1a and disp

DIOPT Version :9

Sequence 1:	NP_001188769.1	Gene:	Npc1a / 34358	FlyBaseID:	FBgn0024320	Length:	1287	Species:	Drosophila melanogaster
Sequence 2:	NP_524734.2	Gene:	disp / 44274	FlyBaseID:	FBgn0029088	Length:	1218	Species:	Drosophila melanogaster

Alignment Length:	1068	Identity:	205/1068 - (19%)
Similarity:	361/1068 - (33%)	Gaps:	356/1068 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 EITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDRE 439
            :..|.|...||..:.:..:|..|.|:  ||.......:::.:           ||.....:||..
  Fly   222 QAATLPTDGWADMHRRQPIEGFFCDS--SPRKEYSHFVVQRI-----------GPNATDSLFDLN 273

  Fly   440 FLTKVLDLQEGIKEINA-----NGTQLKDICYAP---------LSDDGSEIDVSQCVVQSI---- 486
            .|..:..||:.|.|:.:     ....|...|..|         |::..|..|::...|.|:
  Fly   274 GLLAMCQLQDQITEVPSYRAFCEPEMLTTECCRPWSLPNYAAMLANKSSCFDLTTEDVTSLHTLL 338

  Fly   487 ---WGYFGDDRERLDDH----------DEDNGFNVTY--LDALYDCI------SNPYLCLAPYGG 530
               :.||.|  .::|:|          :|....|:.:  |:.|.|..      ||.||..|..
  Fly   339 LGCYEYFHD--LKMDNHCNEIPHCRAPEECKRLNIVFNVLNFLTDFSFIKSNDSNVYLKYAMI-- 399

  Fly   531 PVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLE--NALTWEKKFVEFMTNYT 593
                      |:|...          :|.::..|     |...|:|  |.|      ||.:.
  Fly   400 ----------FIPVAQ----------SNRLLPLF-----HEWEDVELINEL------VEVVA--- 430

  Fly   594 KNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITL 658
                   ||:      .:|:||..|            |::.....:|||      ..|:.:.:.|
  Fly   431 -------MDL------GLENELFNE------------LLLTDVWLVSLG------GTFVMASVWL 464

  Fly   659 GIGGVIIVLASVVS---SVGV-------------FGYIGLPATLIIVEVIPFLVLAVGVDNIFIL 707
            ..|...|.|.|.|:   |:|:             |.|:.|.|.::|:        .:|.|::|:.
  Fly   465 YTGSAFITLMSCVAICFSLGLAYFFYAIVLEFEFFPYMNLLAVVVII--------GIGADDVFLF 521

  Fly   708 VQ----------------THQRDQRKP-------NETLEQQVGRILGKVGPSMLLTSLSESFCFF 749
            ::                |.|.....|       .|:||..:...:.....||.:|||:.:..|:
  Fly   522 LKIWHCVLTERFSNRCTLTTQSQSALPTLENSDHTESLENIMALTMRHAAASMFVTSLTTAGAFY 586

  Fly   750 LGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSN 814
            ....|.:.|::.|.::||..::.::||.||..                          |.|::..
  Fly   587 ASYSSSITAIKCFGIFAGTVVVTNYLLMITWL--------------------------PASVSIM 625

  Fly   815 EGLLYKFFSSVYVPFLMKKI-----------------VRASVMVIFFAWLCF--SIAIAPRIDIG 860
            | .|:....|.:.|..:|.|                 :..|:|...:.||..  ::..:..:.:.
  Fly   626 E-RLFATRMSCHHPMSIKLIHACKKSINRFCQMFEECITKSIMNYAYLWLLIFGALGASSAVIVF 689

  Fly   861 LDQELAMPQDS----FV----LHYFQSLNENLNIGPPVYFVLKGDLAYTNSS-------DQNLVC 910
            ....|.:|:.|    ||    ...:.||.:......|:.       ||.|..       ....|.
  Fly   690 WYPGLQLPEKSHFQLFVSKHPFEVYSSLKQQFWFEKPLQ-------AYENFKMHMHFVWGVQAVD 747

  Fly   911 AGQYCNDDSVLTQIYLASRHSNQTYI-ARPASSWIDDYFDWAAAASSCCK-------YRKDSGDF 967
            .|.|.|.:|     |....:.|...: :|||..||.|:          |:       |::..|..
  Fly   748 DGDYTNPNS-----YGHLHYDNNFNVSSRPAQLWILDF----------CQSVRQQPFYKETLGML 797

  Fly   968 CPHQDTSCL----------RCNITKNSLLR----------PEEKEFVKY-LPFFLKDNPDDTCAK 1011
            .|    :|.          ||....:|..:          |.|....:| ||..:.:..|.|..:
  Fly   798 LP----NCFIENLIDYMKRRCIDDMDSTRKDRSPCCDAQFPFEPHIFEYCLPQSISNMYDTTFFR 858

  Fly  1012 AGHAA-------------YGG-----AVRYSNSH-------ERLNIEASYFMAYHTILKSSADYF 1051
            .|.|.             |.|     :..||.:.       :.|.||....:||.||..:...::
  Fly   859 PGVAGPKFAEAPRLETEDYLGMSGNESAEYSTNGSFTPLLVKALVIEFESNVAYSTIYANIRQFY 923

  Fly  1052 LALESARKISANIT-QMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTL------Q 1109
            .::|...::..... ..|||...::.:.                 ||....|:..||.      .
  Fly   924 ESVEHWFQMQLKTAPPELQGGWFTSDLK-----------------FYNVQDTLSHDTFVAICLAM 971

  Fly  1110 SMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISV 1174
            :..::||..|.|..::       ::..|:|:::.:.|...::......||.:..:.:..|:|::|
  Fly   972 AASLAVLLCFTVNILI-------SIYAVLTVSLSIFNTVAVLILLGWQLNILESIAVSTAIGLAV 1029

  Fly  1175 EFCSHLVHSFATSKSVSQIDRAADSLSK-MGSSIFSGITLTKFAGIL----VLAFAKSQIFQV-- 1232
            :|..|....:..|....::......||: :|.::.:..|.....||:    :|.:.:..:|.|
  Fly  1030 DFSLHYGIHYRMSPVKERLAATQFVLSRIIGPTVMAATTTGLAGGIMMASNILPYIQIGVFLVVV 1094

  Fly  1233 -----FYFRMYLG--IVVIGAAHGLIFL 1253
                 ||...:|.  :.|.|..||.:.|
  Fly  1095 MIVSWFYATFFLMSLLRVAGPQHGFLEL 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_001188769.1	NPC1_N	31..274	CDD:293023
		2A060601	33..1261	CDD:273337	205/1068 (19%)
		Sterol-sensing	651..804	CDD:289145	38/191 (20%)
disp	NP_524734.2	Patched	<444..1111	CDD:280598	141/757 (19%)
		MMPL	457..627	CDD:304422	41/204 (20%)
		TM_PBP1_branched-chain-AA_like	964..>1109	CDD:294309	27/151 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840