DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1a and ptc

DIOPT Version :9

Sequence 1:	NP_001188769.1	Gene:	Npc1a / 34358	FlyBaseID:	FBgn0024320	Length:	1287	Species:	Drosophila melanogaster
Sequence 2:	NP_523661.2	Gene:	ptc / 35851	FlyBaseID:	FBgn0003892	Length:	1286	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	230/1087 - (21%)
Similarity:	394/1087 - (36%)	Gaps:	308/1087 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 PYSENDSYFEKLGAH-----TETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITT 378
            |..|...|.|::..|     ..|.|:.|   |       .|..|:...|.|||.|.....:..|.
  Fly   185 PSFEGIYYIEQILRHLIPCSIITPLDCF---W-------EGSQLLGPESAVVIPGLNQRLLWTTL 239

  Fly   379 DPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKA------VNLPQIVHNTSNGPYTFGPVFD 437
            :|..:......|...|:..||     |..:||.:.:|      :..|.:.....|.|.| .|
  Fly   240 NPASVMQYMKQKMSEEKISFD-----FETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDT-AP--- 295

  Fly   438 REFLTKVLDLQEGIKEINANGTQLKDI-------CYA----------PLSDDGSEIDVS------ 479
                             |.|.||..|:       ||.          .|...|::.:.|
  Fly   296 -----------------NKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKA 343

  Fly   480 ---QCVVQSIWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGF 541
               |.|||.:      ..:.:.|..:|| :.|.:|
  Fly   344 QALQSVVQLM------TEKEMYDQWQDN-YKVHHL------------------------------ 371

  Fly   542 LPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKKF---VE--------FMTNYTKN 595
                    |.|:.:.|..:                ||  |::.|   ||        ..|||
  Fly   372 --------GWTQEKAAEVL----------------NA--WQRNFSREVEQLLRKQSRIATNY--- 407

  Fly   596 NMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGI 660
                  ||...|..:::|.|.:.|....|:|::...:..:|...:|...::..|    .:.::|:
  Fly   408 ------DIYVFSSAALDDILAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVR----GQSSVGV 462

  Fly   661 GGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQ 725
            .||:::..|..:.:|:...:|:.......:|:|||.|.:|||:||:|...:....|:      :|
  Fly   463 AGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAESNRR------EQ 521

  Fly   726 VGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTK 790
            ...||.|||||:|.::.|.:..||......:||::.|.|.|.:.:..:....:..|.::.:||.:
  Fly   522 TKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLR 586

  Fly   791 RREENRMDI--CCFIKGKKPDSI-------TSNEG------------------------------ 816
            ||...|.||  |||...|:...:       .:|.|
  Fly   587 RRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGARHPKSCNNNRVPLPAQNPLLEQRADIP 651

  Fly   817 ---------LLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSF 872
                     .|..|....|.||||:..|:...::.|.|.|..|:..:.|:..|||....:|:||.
  Fly   652 GSSHSLASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPKDSN 716

  Fly   873 VLHYFQSLNENLNIGPPVYFVLKGDLAYTNSS-------DQNLVCAGQYCNDDSVLTQIYLASRH 930
            . |.|......|.....:|.|.:|:..|....       |..:.......||:..|...:|..
  Fly   717 E-HKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLL-- 778

  Fly   931 SNQTYIARPASSWI--------DDYFD-------WAAAASS----CCKYRKDSGDFCPHQDTSCL 976
                     .|.|:        ::|.|       |...|||    ..|....:|    |.|....
  Fly   779 ---------FSEWLGNLQKIFDEEYRDGRLTKECWFPNASSDAILAYKLIVQTG----HVDNPVD 830

  Fly   977 RCNITKNSLLRPE----EKEFVKYLPFFLKDNPDDTCAKAGHAAYGGA-----------VRYSNS 1026
            :..:..|.|:..:    ::.|..||..:..::.         .|||.:           ....|.
  Fly   831 KELVLTNRLVNSDGIINQRAFYNYLSAWATNDV---------FAYGASQGKLYPEPRQYFHQPNE 886

  Fly  1027 HERLNIEASYFMAYHTILKSSADYFL-ALESARKISANITQM--LQGRLMSNGVPMASALTVEVF 1088
            :: |.|..|..:.|     :...::| .|....:|...|..:  |..:....|:|.        :
  Fly   887 YD-LKIPKSLPLVY-----AQMPFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPN--------Y 937

  Fly  1089 PYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYY 1153
            |..:.::|:|||:|:.|.....:...:|:..|:..:|: ..|.:|::|::::...:..:.|.|..
  Fly   938 PSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLL-LSVWAAVLVILSVLASLAQIFGAMTL 1001

  Fly  1154 WNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKM--GSSIFSGITLTKF 1216
            ..|.|:|:..|.|:::||:.:  |.:::.|.....||....|......:|  |..:...:|
  Fly  1002 LGIKLSAIPAVILILSVGMML--CFNVLISLGFMTSVGNRQRRVQLSMQMSLGPLVHGMLT---- 1060

  Fly  1217 AGILVLAFAKSQI-FQVFYFRMYLGIVV-IGAAHGLIFLPVLLSYIG 1261
            :|:.|...:.|.. |.:.:|...|.:|: :||.:.|:..|:|||.:|
  Fly  1061 SGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVG 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_001188769.1	NPC1_N	31..274	CDD:293023
		2A060601	33..1261	CDD:273337	229/1085 (21%)
		Sterol-sensing	651..804	CDD:289145	46/154 (30%)
ptc	NP_523661.2	2A060602	17..1134	CDD:273338	230/1087 (21%)
ptc	NP_523661.2	MMPL	454..598	CDD:304422	44/153 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840