DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and Scap

DIOPT Version :10

Sequence 1:NP_609357.2 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:NP_001094436.1 Gene:Scap / 301024 RGDID:1309378 Length:1276 Species:Rattus norvegicus


Alignment Length:503 Identity:101/503 - (20%)
Similarity:198/503 - (39%) Gaps:120/503 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 FTKWGTYFASNP-------GLTLIAGASLVVILGY-GINFIEITTDPVKLWASPNSKS------- 391
            |...|...||.|       ||.::|....::.|.. |...:|.:| |||.::.|.:.|       
  Rat    15 FYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFST-PVKGYSPPPADSDHKQGEP 78

  Fly   392 -------------RLEREFFDTKFSPFYR-------LEQIIIKAVNLPQIVHN----TSNGPYTF 432
                         .:::.|..:..||::|       ....:.:|..|.:.:.|    .|:|..:.
  Rat    79 SEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSL 143

  Fly   433 GPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERL 497
                 .|...:|.||..|::::.           :.|.:.|       |::.|...::.:|.||.
  Rat   144 -----EEVCLQVTDLLPGLRKLR-----------SLLPEHG-------CLLLSPGNFWQNDWERF 185

  Fly   498 DDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIIL 562
            .                                 .||.|.  |.:...:..|..|...|.:   |
  Rat   186 H---------------------------------ADPDII--GTIHQHEPKTLQTSATLKD---L 212

  Fly   563 TFLVKNHHNKTDLEN---------ALTWEKKFVEFMTNYTKNNMSQY--MDIAFTSERSIEDELN 616
            .|.|...::...|..         .|.:::...:|:::.....|..:  .:.:..:|..:.....
  Rat   213 LFGVPGKYSGVSLYTRKRMVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFK 277

  Fly   617 RE-SQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYI 680
            .| ..::::.::.:|:|:|.||..|...:.     .:.||..|.:..|:.||:|::.|||:....
  Rat   278 EEIGIAELIPLVTTYIILFAYIYFSTRKID-----MVKSKWGLALAAVVTVLSSLLMSVGLCTLF 337

  Fly   681 GLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSES 745
            ||..||...|:.|:||:.:|::|:.:|  |........:..::.::.:.|.....|::....:|.
  Rat   338 GLTPTLNGGEIFPYLVVVIGLENVLVL--TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATEL 400

  Fly   746 FCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRRE 793
            ....:|..:.:||::.|.|:|.|.|:.||.||:..|.::.::|.:|.|
  Rat   401 GIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRME 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_609357.2 2A060601 33..1261 CDD:273337 101/503 (20%)
ScapNP_001094436.1 2A060601 <11..>466 CDD:273337 101/503 (20%)
Loop-1. /evidence=ECO:0000250|UniProtKB:P97260 46..284 46/299 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..81 5/20 (25%)
Sterol-sensing 308..452 CDD:463544 41/143 (29%)
ER export signal. /evidence=ECO:0000250|UniProtKB:P97260 447..452 1/2 (50%)
Loop-7. /evidence=ECO:0000250|UniProtKB:P97260 535..710
Interaction with SREBF2. /evidence=ECO:0000250|UniProtKB:P97260 731..1276
WD40 771..802 CDD:197651
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..903
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 928..958
WD40 repeat 1008..1044 CDD:293791
WD40 1075..>1232 CDD:475233
WD40 repeat 1079..1113 CDD:293791
WD40 repeat 1120..1153 CDD:293791
WD40 repeat 1160..1194 CDD:293791
Blue background indicates that the domain is not in the aligned region.

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