DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and SCAP

DIOPT Version :9

Sequence 1:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:NP_036367.2 Gene:SCAP / 22937 HGNCID:30634 Length:1279 Species:Homo sapiens


Alignment Length:499 Identity:104/499 - (20%)
Similarity:195/499 - (39%) Gaps:124/499 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 NPGLTLIAGASLVVIL--GY---------------GINFIEITTDPVKLWASPNSKSRLER---- 395
            |.|| |.|...:.:||  |:               |...:|.|| |||.::.|...|..::    
Human    17 NHGL-LCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTT-PVKDYSPPPVDSDRKQGEPT 79

  Fly   396 ---EFFDTKFSPFYRLEQIIIKAVNLP----QIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKE 453
               |::  ..:|...::||.:|:...|    .:..:....|.:.......|....||....||:.
Human    80 EQPEWY--VGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRS 142

  Fly   454 INANGTQLKDICYAP--------LSDDGSEIDVSQCVVQSIWGYFGDDRER----------LDDH 500
            :.....|:.|:  .|        |.:.|       |::.|...::.:|.||          :..|
Human   143 LEELCLQVTDL--LPGLRKLRNLLPEHG-------CLLLSPGNFWQNDWERFHADPDIIGTIHQH 198

  Fly   501 DEDN-GFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTF 564
            :... ..:.|..|.|:..                          || :.:|.:.:.....:..|.
Human   199 EPKTLQTSATLKDLLFGV--------------------------PG-KYSGVSLYTRKRMVSYTI 236

  Fly   565 -LVKNHHNKTDLENALTWEKKFV-----EFMTNYTKNNMS----QYMDIAFTSERSIEDELNRES 619
             ||..|::           .||:     ..|..:...|.|    ..:.:.|..|..:        
Human   237 TLVFQHYH-----------AKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGV-------- 282

  Fly   620 QSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPA 684
             ::::.::.:|:|:|.||..|...:.     .:.||..|.:..|:.||:|::.|||:....||..
Human   283 -AELIPLVTTYIILFAYIYFSTRKID-----MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTP 341

  Fly   685 TLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFF 749
            ||...|:.|:||:.:|::|:.:|  |........:..::.::.:.|.....|::....:|.....
Human   342 TLNGGEIFPYLVVVIGLENVLVL--TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIIL 404

  Fly   750 LGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRRE 793
            :|..:.:||::.|.|:|.|.|:.||.||:..|.::.::|.:|.|
Human   405 IGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRME 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023
2A060601 33..1261 CDD:273337 104/499 (21%)
Sterol-sensing 651..804 CDD:289145 41/143 (29%)
SCAPNP_036367.2 Loop-1. /evidence=ECO:0000250|UniProtKB:P97260 46..284 49/296 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80 5/19 (26%)
Sterol-sensing 308..457 CDD:289145 41/143 (29%)
ER export signal. /evidence=ECO:0000250|UniProtKB:P97260 447..452 1/2 (50%)
Loop-7. /evidence=ECO:0000250|UniProtKB:P97260 535..710
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..615
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..696
Interaction with SREBF2. /evidence=ECO:0000250|UniProtKB:P97260 731..1279
WD40 <771..813 CDD:295369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 811..904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..962
WD40 939..>1235 CDD:225201
WD40 repeat 959..1005 CDD:293791
WD40 repeat 1011..1047 CDD:293791
WD40 1078..>1235 CDD:295369
WD40 repeat 1082..1116 CDD:293791
WD40 repeat 1123..1157 CDD:293791
WD40 repeat 1163..1197 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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