DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Npc1a and SCAP

DIOPT Version :10

Sequence 1:NP_609357.2 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:NP_036367.2 Gene:SCAP / 22937 HGNCID:30634 Length:1279 Species:Homo sapiens


Alignment Length:499 Identity:104/499 - (20%)
Similarity:195/499 - (39%) Gaps:124/499 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 NPGLTLIAGASLVVIL--GY---------------GINFIEITTDPVKLWASPNSKSRLER---- 395
            |.|| |.|...:.:||  |:               |...:|.|| |||.::.|...|..::    
Human    17 NHGL-LCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTT-PVKDYSPPPVDSDRKQGEPT 79

  Fly   396 ---EFFDTKFSPFYRLEQIIIKAVNLP----QIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKE 453
               |::  ..:|...::||.:|:...|    .:..:....|.:.......|....||....||:.
Human    80 EQPEWY--VGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLSRAFQLVEEIRNHVLRDSSGIRS 142

  Fly   454 INANGTQLKDICYAP--------LSDDGSEIDVSQCVVQSIWGYFGDDRER----------LDDH 500
            :.....|:.|:  .|        |.:.|       |::.|...::.:|.||          :..|
Human   143 LEELCLQVTDL--LPGLRKLRNLLPEHG-------CLLLSPGNFWQNDWERFHADPDIIGTIHQH 198

  Fly   501 DEDN-GFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTF 564
            :... ..:.|..|.|:..                          || :.:|.:.:.....:..|.
Human   199 EPKTLQTSATLKDLLFGV--------------------------PG-KYSGVSLYTRKRMVSYTI 236

  Fly   565 -LVKNHHNKTDLENALTWEKKFV-----EFMTNYTKNNMS----QYMDIAFTSERSIEDELNRES 619
             ||..|::           .||:     ..|..:...|.|    ..:.:.|..|..:        
Human   237 TLVFQHYH-----------AKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGV-------- 282

  Fly   620 QSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPA 684
             ::::.::.:|:|:|.||..|...:.     .:.||..|.:..|:.||:|::.|||:....||..
Human   283 -AELIPLVTTYIILFAYIYFSTRKID-----MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTP 341

  Fly   685 TLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFF 749
            ||...|:.|:||:.:|::|:.:|  |........:..::.::.:.|.....|::....:|.....
Human   342 TLNGGEIFPYLVVVIGLENVLVL--TKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIIL 404

  Fly   750 LGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRRE 793
            :|..:.:||::.|.|:|.|.|:.||.||:..|.::.::|.:|.|
Human   405 IGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRME 448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_609357.2 2A060601 33..1261 CDD:273337 104/499 (21%)
SCAPNP_036367.2 2A060601 <11..>466 CDD:273337 104/499 (21%)
Loop-1. /evidence=ECO:0000250|UniProtKB:P97260 46..284 49/296 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80 5/19 (26%)
Sterol-sensing 308..452 CDD:463544 41/143 (29%)
ER export signal. /evidence=ECO:0000250|UniProtKB:P97260 447..452 1/2 (50%)
Loop-7. /evidence=ECO:0000250|UniProtKB:P97260 535..710
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 579..615
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..696
Interaction with SREBF2. /evidence=ECO:0000250|UniProtKB:P97260 731..1279
WD40 771..802 CDD:197651
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 811..904
WD40 893..1235 CDD:441893
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..962
WD40 repeat 959..1005 CDD:293791
WD40 repeat 1011..1047 CDD:293791
WD40 1078..>1235 CDD:475233
WD40 repeat 1082..1116 CDD:293791
WD40 repeat 1123..1157 CDD:293791
WD40 repeat 1163..1197 CDD:293791
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.