Protein Alignment Npc1a and ptr-21

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: NP_490751.1
• Gene: ptr-21 / 191752
• WormBaseID: WBGene00004235
• Length: 909
• Species: Caenorhabditis elegans
• Alignment Length: 1007
• Identity: 187/1007 - (18%)
• Similarity: 376/1007 - (37%)
• Gaps: 233/1007 - (23%)

  Fly   327 FEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEI-TTDPVKLWASP-NS 389
            ||.||......|...:...|......|...:||   .|::...|:..|.: ..|.|:...:| ||
 Worm    28 FELLGPVNNISLADMYKVCGKIIGRFPIAFIIA---TVIMCSGGLGTIGLELKDNVRDGYTPKNS 89

  Fly   390 KSRLE----REFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKV----LD 446
            .||||    |||..::..|.            :..::....:|    |.:...::|.:.    |.
 Worm    90 LSRLENRLYREFLSSEGDPV------------MTTVLMTAKDG----GSMHRIKYLEEAQRQWLY 138

  Fly   447 LQEGIKEINANGTQLK--DIC--YAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGFN 507
            :.:.:.....||..:|  |.|  |              |....|.|||.|..:......:.:|:.
 Worm   139 ISKNLSADVGNGEFMKFGDFCGHY--------------CQANDIIGYFLDAYKTKSADPKMDGYQ 189

  Fly   508 VTYLDALYDCISNPYLCLAPYGGPVDPAIA---------LGGFLPPGDQLTGSTKFELANAIIL- 562
            :.|                    |:...:.         .|..:...|.:|.....::....:|
 Worm   190 LNY--------------------PITTVMGYQLHLERNFFGVTVNQSDPVTNIQSMKVLTLPVLS 234

  Fly   563 ---TFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYM-DIAFTSERSIEDELNRESQSDV 623
               ||        .|.:....||.....:.|.|:......:: :|.......::.|:|:::|..|
 Worm   235 EVRTF--------EDTDKLNKWELAVYNYATGYSALEGDDHLVEINVIGAEVVDTEMNKDAQKMV 291

  Fly   624 LTILVSYLIMFMYI----AISLGHVKEFK-RVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLP 683
            ...:|..:.|.::|    :||..:...|. |:.:     :.:..:::.:.:::::.|:...:| .
 Worm   292 PYFIVGIVSMIIFIFCTVSISASYYGYFSWRIGL-----IALACLLVPILAILTAFGINNMLG-N 350

  Fly   684 ATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCF 748
            .|...:.::|||:..:||::.|:.:|...  |..|:....:::|.:|.:.|||:..|:|:....|
 Worm   351 RTNSPMMIMPFLINGIGVNDAFLTLQNWL--QHSPDLPSGKRLGYMLAEAGPSITTTTLTNVIVF 413

  Fly   749 FLGGLSDMPAVRAFALYAGVALIIDFLLQIT--CFVSLFTLDTKRREENRMDICCFIKGKKPDSI 811
            .:|.::....:..|.|...::|::.::..:|  |.|.:..|..:..|.:::
 Worm   414 LIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLVLLLSERVNEPSKL-------------- 464

  Fly   812 TSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHY 876
               ||...|.. ..|...:..:...|.:::....:..|.|.....|...|:....:|.::.:...
 Worm   465 ---EGTFNKVL-GFYAKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETPIRKP 525

  Fly   877 FQSLNENL-NIGPPVYFVLKGDLAYTNSSD----QNLV--------CAGQYCNDDSVLTQIYLAS 928
            .:.:.|.: ....||..::...:..:|::.    .|||        |.|         ::..::.
 Worm   526 NRIIEETVWKEFYPVTVIVNSPVDISNANALRAFDNLVHDFESMEKCRG---------SEYTISP 581

  Fly   929 RHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEF 993
            ....|||.                       |...:.||...::|    ...|.:||      :|
 Worm   582 IRDYQTYF-----------------------YGVGAEDFDYEEET----VKNTSHSL------DF 613

  Fly   994 VKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESAR 1058
            .|...|..  ||     ...|...|..:.:||......::..:                |.|:..
 Worm   614 SKLTGFLA--NP-----IYKHHKGGLKLNFSNPVPIRKVQLIF----------------AYENVT 655

  Fly  1059 KISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTM----WSDTLQSMG--ISVLS 1117
            .....|..|...|.::     :|.:.:.|..::|..:|.:|.|::    .|:.|.::|  .:|..
 Worm   656 SWDERIQIMQDWRTIA-----SSHVALNVSVWNVNAMFVDQMLSLKGLAISNALVTLGCMAAVCV 715

  Fly  1118 IFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLV- 1181
            :|:...:.:|....|.|.:.|.:|       |.:.:|::.|:.|:|..:::::|:||:|.:|:.
 Worm   716 VFIRNPLSVGLATASILSISIGVT-------GYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVAC 773

  Fly  1182 ------HSFATSKSVSQID------RAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFY 1234
                  ..|.....:.:|:      |..:|||.:...:....:.|... :|.|...::.:..||
 Worm   774 HYQVRYKEFEEKGVLKRIEMKTPESRVVNSLSNVLWPMVQSASSTLLC-VLPLGILQNYLPMVF- 836

  Fly  1235 FRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSN 1266
            .:..|.:|:.|..|||:.||.:|:.....|.|
 Worm   837 VKTILLVVIWGMFHGLVLLPCILAQFPLSVFN 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	185/1000 (19%)
ptr-21	NP_490751.1	Patched	83..863	CDD:308203	171/942 (18%)