Protein Alignment Npc1a and ptr-13

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: NP_496392.2
• Gene: ptr-13 / 191748
• WormBaseID: WBGene00004227
• Length: 851
• Species: Caenorhabditis elegans
• Alignment Length: 960
• Identity: 200/960 - (20%)
• Similarity: 370/960 - (38%)
• Gaps: 203/960 - (21%)

  Fly   345 WGTYFASN-PGLTLIA-GASLVVILGYGINF-IEITTDPVKLWASPNSKSRLEREFFDTKFSPFY 406
            |.:|:..| |...|.: ...|:.:|.|.:.: :||..|..:.:|:.:..:..|.    ||||.||
 Worm    24 WISYYLGNHPRCVLFSVFCVLIPLLSYFVIYPLEIECDIRRGFANKHGHAVEEL----TKFSNFY 84

  Fly   407 RLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDICYAPLSD 471
                             |.|.|......|..|...|.. ||...:|.:|
 Worm    85 -----------------NISVGGLEIWGVLARNKTTDT-DLHINLKLLN---------------- 115

  Fly   472 DGSEIDVSQCVVQSIWGY---FGDDRERLDD-HDEDNGFNVTYLDALYDC-----ISNPYLCLAP 527
               |||.   :.|.:|.|   :..:..|..| ..||..:...|...|...     ::..|.....
 Worm   116 ---EIDQ---LHQFVWNYTTQYKQETIRFKDLSSEDINYVFNYYRKLLAIEWMPGVNLSYPLAEA 174

  Fly   528 YGGPVDPAIALGG--FLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKK----FV 586
            :|.|    ..||.  |.....|.:.:...:.|..:.|.::.|          |.|:|:|    .|
 Worm   175 FGHP----FYLGNQFFGVNNGQASKAGPIKTAKFVALWYMSK----------AETFEQKQKLQAV 225

  Fly   587 E---FMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFK 648
            :   |..:..:.|..|: |.....::....|:.|.:.:.|....:...:|..::|.:      |.
 Worm   226 QLGIFKKSAERPNNLQF-DFEMFGDQVANSEMLRGTLTTVKLFFIGGCLMVAFMACT------FT 283

  Fly   649 RVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQR 713
            .:.|.||..|..|.:...||:..:...:.|::|.|...|:. :.|||:|.:|||:.|:|:...:|
 Worm   284 ELTIFSKCMLIAGAIGSPLAATGACFAILGWVGHPFNSIMC-ITPFLILGIGVDDAFLLLNCWRR 347

  Fly   714 DQRKPN--ETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLL 776
            ::.|..  :..|.|:.|::.::.|||.:|||:.:..|.:|.|:..|.:.:|.|...:|:::||||
 Worm   348 EEGKDKSAKQAENQLARVIREISPSMAITSLTNTMAFGVGFLAPTPQMSSFCLGTALAIVLDFLL 412

  Fly   777 QITCFVSLFTLDTKRRE-----ENRMDICCFIKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVR 836
            :...||....|..|::.     ||..    |...|......::.|...:.....:...|:....|
 Worm   413 EFLIFVPCMVLFYKKKPEIIAIENEE----FANEKTEKRSETSTGKYSRINWKCFTNLLLSVPGR 473

  Fly   837 ASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFV---LHYFQSLNENLNIGPPVYFV----- 893
            ..|::::|:....|.....:::...|.....|.||.:   |..|.|:....:   |:.|:
 Worm   474 VLVIILYFSIFTASYFGVAKMEKTFDPSKTFPSDSKLVDSLASFTSIQVEYS---PLNFLSSVPD 535

  Fly   894 LKGDLAYTNSSDQ-NLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSC 957
            ||.|....|.::. :.:...:.|..|       :.|.:..:.|:         .:.:::
 Worm   536 LKNDTDVANFNEMLHKLEFREECYGD-------VGSHNMYRDYV---------QFLNYS------ 578

  Fly   958 CKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVR 1022
                                 |||..|         ..:|..|||..        |.|.. |.::
 Worm   579 ---------------------NITDKS---------YNHLEKFLKGR--------GMADV-GTIK 604

  Fly  1023 YSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEV 1087
            |........|:...|:......:..|:..:.:|..|:|..:.                |...:.:
 Worm   605 YHKEGNDTIIDMINFVVVCQGREKWAERAVNVEKTRQILVDY----------------SDYNITL 653

  Fly  1088 FPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMY 1152
            |.|.  ...|:..:|:..:.::|:.|:...:.:..||:|...|...:..|.|:: |...|.|.:.
 Worm   654 FDYD--GTIYDLIITVKGELVKSLAITFTCMTIACFVIMPSFVAPTIASVATVS-ISFCLIGFLS 715

  Fly  1153 YWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSV---SQIDRAADSLSKMGSSIFSGITLT 1214
            .|..:|:.|::::::||:|.||::.:|:.:.:..::..   |:.:.....|..:|..:......|
 Worm   716 IWGQNLDPVTMIDVIMAIGFSVDYSAHVCYHYYCAREQHLGSKHEVITSVLQAVGRPVVEASLTT 780

  Fly  1215 KFAGILVLAFAKSQIFQVFYFRMYLGIVVI----GAAHGLIFLPVLLSYI 1260
                  :|..|...:..|:..:.:...|.:    |..|||.||||:|.:|
 Worm   781 ------LLCMAPLFVVPVYMIQSFAKTVTLVTSFGLLHGLFFLPVVLYFI 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	200/960 (21%)
ptr-13	NP_496392.2	Patched	112..821	CDD:308203	171/845 (20%)