Protein Alignment Npc1a and ptr-8

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: NP_496343.1
• Gene: ptr-8 / 174678
• WormBaseID: WBGene00004222
• Length: 890
• Species: Caenorhabditis elegans
• Alignment Length: 1021
• Identity: 198/1021 - (19%)
• Similarity: 377/1021 - (36%)
• Gaps: 272/1021 - (26%)

  Fly   344 KWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDP----VKLWASPNSKSRLEREFFDTKFSP 404
            |.|:..|..|.:|:|....|..::.     |::...|    :..:||.:|.||.|
 Worm    20 KIGSTVARYPVITIIFCLVLSAVMS-----IKLALTPKVSAIDGYASDDSMSRHE---------- 69

  Fly   405 FYRLEQIIIKAVNLPQIVHNTSNGP-----------YTFGPVFDREFLTKVLDLQEGIK---EIN 455
            |...:|.:            .|:||           .|.|.:.:.:.|.:|:.:.:.|.   ::|
 Worm    70 FKTFQQFL------------DSDGPGITTAILIRSSITNGSLLEEQRLKEVVKVSDFISTNFKLN 122

  Fly   456 ANGTQ------LKDICYA--PLSD--DGSEIDVSQCVVQSIWGYFGDDR-----ERLD-DHDEDN 504
            .:|.:      .:..|.|  |:..  :|.:|             .|.::     :|:| .:...|
 Worm   123 VSGVEKNFNQFCRGFCQANEPVRQYYNGLQI-------------LGKNQTDGISKRIDLSYPTSN 174

  Fly   505 GFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNH 569
            .|.     ..:..|.|.:            .|::.   |.|..|..|      |.|:|.|..:.:
 Worm   175 FFG-----RKFSLIPNFF------------GISMS---PEGQHLNSS------NLIVLYFRAERY 213

  Fly   570 HNKTDLENALTWEKKFVE-----FMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVS 629
            .:         |..|.|:     ...::.|...|..:.:...|:..:|.|:.|...|....::|.
 Worm   214 PD---------WSTKTVKQWELRVRDHFAKEYSSDLIIVDVMSQTVVESEIVRAGLSLQPFLIVG 269

  Fly   630 YLIMFMYIAISLGHVKEFKRVFIDS------KITLGIGGVIIVLASVVSSVGVFGYIGLPATLII 688
            ::||.::..::    ..|..|::.|      |:.|.|...|....:..:::|:..:.|:..:.|:
 Worm   270 FVIMSIFCTVT----TMFSAVYLYSQKATFNKVALSIIACINPFMACGTAMGILFFCGVTFSPIM 330

  Fly   689 VEVIPFLVLAVGVDNIFILVQTHQRDQR-------KPNETLEQQVGRILGKVGPSMLLTSLSESF 746
            . :.||||||:.||:.|:::....|.:.       ||..  |..:|.:|.:.||::.:::.:...
 Worm   331 C-ITPFLVLAISVDDSFLMLHAWNRLESWRTAPLDKPMR--EHMMGEVLVETGPAISISAFTNML 392

  Fly   747 CFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTL--DTKRREENRMDICCFIKGKKPD 809
            .|.:|.::..|.:|.|......|:.:|...|.|.:.:..||  |||..|.         ..:|..
 Worm   393 AFTIGAITSPPEIRIFCFGNAAAIFMDMFYQATFYTACMTLLGDTKNSEG---------VSEKTK 448

  Fly   810 SITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVL 874
            .|....|.:...|...||..:....|...:::::..::.|::....|:.:.|.......:||.:|
 Worm   449 RIQERMGNVVGRFLKWYVNAISNIFVSFGIVLVWAVFIGFAVLGLTRLHVELRPSKFFLKDSPML 513

  Fly   875 HYFQSL--NENLNIGPPVYFVLK--GDLAYTNSSDQNLVCAGQYCNDDSV--LTQIYLASRHSNQ 933
             |...|  ||.:....||:.::.  |||.                ||.:|  |.::.....|...
 Worm   514 -YMDRLRTNEVVPYYTPVHVIVNNPGDLT----------------NDSNVERLVELKEKLEHMPN 561

  Fly   934 TYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLRPEEKEFVKYLP 998
            ...|.....::||:..:.::.:.  :...|..:    .|:...:.:|          ::|:::..
 Worm   562 AIGAPSTKFFLDDFVQYRSSFAE--EIEMDIAE----DDSESEKSDI----------EQFLEWPE 610

  Fly   999 FFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYF-MAYHTILKSSADYFLALESARKISA 1062
            |               :.:.|.:|:.|.....|:....| ..:|     ..|    |:...|
 Worm   611 F---------------SFWRGFLRFDNQTHPHNVTKFMFTTGFH-----GQD----LKDWNK--- 648

  Fly  1063 NITQMLQGRLMS--NGV--PMASALTVEVFPYSVFYV-FYEQYLTM-WSDTLQSMGISVLSIFV- 1120
                  :|:|:.  .|.  .........||....|:: ..:...|: |..||.:.      |||
 Worm   649 ------RGQLLKRWRGAVEEFKDDFNTTVFTEDAFFLDMIDSIPTVTWQTTLATF------IFVS 701

  Fly  1121 -VTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSH----- 1179
             |.|:.:. |:.:.::|.:...:..|.:.|.:....::|:.|.:...:|.:|.||:..:|
 Worm   702 LVCFLFIS-DILTVMIVSVATLVTSVGVFGYLSLLGVTLDPVIMSIAIMCIGFSVDIPAHVAFHF 765

  Fly  1180 ------------------------LVHSFATSKSVSQIDRAADS--------LSKMGSSIFSGIT 1212
                                    :|||.:|:.|........:|        ||.:|..:.....
 Worm   766 YAAKAKKHASSHSQPSPHQVTSPDIVHSTSTTSSSDSSISTPNSFETNLNFALSSVGFPVIQAGV 830

  Fly  1213 LTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLS 1258
            .|.|.. |.|.|.:..:.::|...:.| .|.:...||||.:|.|||
 Worm   831 STDFCA-LPLGFMELYMAKMFALSLTL-CVSLSLIHGLIVIPALLS 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	198/1021 (19%)
ptr-8	NP_496343.1	Patched	56..874	CDD:308203	187/978 (19%)