DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and scp-1

DIOPT Version :9

Sequence 1:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:NP_001022051.1 Gene:scp-1 / 174479 WormBaseID:WBGene00004744 Length:1087 Species:Caenorhabditis elegans


Alignment Length:628 Identity:116/628 - (18%)
Similarity:228/628 - (36%) Gaps:130/628 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   345 WGTYFASNPGLTLIAGASLVVILGY-GINFIEI-TTDPVKLWASPNSKSRLEREFFDTKFSPFYR 407
            :|...|::|...|......:::|.| .|..:.: .:.|:.::.|       |....:.|.:||:.
 Worm    23 YGRLCAAHPKACLSMSLLTMIVLSYPTITRLRLPVSTPIDVFWS-------EHLHVNDKIAPFWI 80

  Fly   408 LEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGTQLKDIC--YAPLS 470
            .|.   .|..:.|.:.:|:..|:....:.....:...:.....|::|......::::|  .|...
 Worm    81 NEN---PASYIQQFIVSTTISPWNATEMGPEHAVRAAIATAFRIRQILLAEPAVEELCLRLANQR 142

  Fly   471 DDGS--EIDVSQCVV---QSIWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAP--Y 528
            .|.|  ....|.|||   .||| |....:.|.||......||       ..|.|.  .|:..  .
 Worm   143 QDSSWPFRSKSLCVVLSPASIW-YNNLQKFREDDDTITTVFN-------EHCKST--FCMRDLLL 197

  Fly   529 GGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTWEKKFVEF-MTNY 592
            |.|    ||..| :....|.....|.|.|   :..|..:  ::|..::...  ||...|| :.:.
 Worm   198 GAP----IAATG-IKQKYQTNRKRKIEFA---VTMFFAR--YSKKVIQGIR--EKLQKEFELVDT 250

  Fly   593 TKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKIT 657
            ..|:...::.:.|...::.         ||.:.::.:|.:..:|:..|...::     .:.|:..
 Worm   251 PPNDQRTFVQVYFHPLKTF---------SDYIPLISTYFVCMIYVYYSSRKIQ-----MVASRWG 301

  Fly   658 LGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETL 722
            |.......|.::::.:.|:..::.|..|....||.|::.|.:|::|...:  |.......|:..:
 Worm   302 LAFASSFTVASTLLMTTGICAHLDLSTTTWGSEVYPYIALIMGLENTLCI--TRSVVYTSPSLDV 364

  Fly   723 EQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTL 787
            ..::...|.:.|..:....:.|.....:|.|:.:..::.|..::.:.:.:||.:|:..:....|.
 Worm   365 SSRIAHGLSQEGYKLTKYYILELLALLIGFLTRISDIQEFCQFSVICVTVDFYMQLFFYAPCLTF 429

  Fly   788 DTKR-------------------REENRMDICC---------FIKGKKPDSITSNEG-------- 816
            |.:|                   |.:|...:.|         |:..|......|:.|        
 Worm   430 DLQRLGLEEKRKFAEILLYEEIPRLKNYAPVSCPMRKIWPKLFVMKKMQKRRVSDSGIEDVMKND 494

  Fly   817 -----LLYKFFSS-----VYVP------------FLMK-KIVRASVMVIFFAWLCFSIAIAPRID 858
                 |:...|.|     |..|            |:.: :||:.:::|:|..|..|.:.......
 Worm   495 EQRRLLISSEFDSKDDGDVQEPRPEDSVRMKIMYFITRTRIVQRTILVVFAIWTVFLVFFVGSRQ 559

  Fly   859 IGLDQELAMPQDSFVLHYFQSLN-ENLNIG----------PPV 890
            :|::..|.......:....:.|: .||..|          |||
 Worm   560 LGMESNLTNQSIESLTRSHRILSTANLQYGNWQRRTYKWWPPV 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023
2A060601 33..1261 CDD:273337 116/628 (18%)
Sterol-sensing 651..804 CDD:289145 30/180 (17%)
scp-1NP_001022051.1 Sterol-sensing 295..448 CDD:289145 26/154 (17%)
WD40 <727..1043 CDD:225201
WD40 727..959 CDD:295369
WD40 repeat 735..770 CDD:293791
WD40 repeat 791..826 CDD:293791
WD40 repeat 833..875 CDD:293791
WD40 repeat 883..919 CDD:293791
WD40 repeat 926..949 CDD:293791
WD40 repeat 967..1005 CDD:293791
WD40 repeat 1016..1040 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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