Protein Alignment Npc1a and ptr-17

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: NP_001364498.1
• Gene: ptr-17 / 173150
• WormBaseID: WBGene00004231
• Length: 905
• Species: Caenorhabditis elegans
• Alignment Length: 1015
• Identity: 209/1015 - (20%)
• Similarity: 397/1015 - (39%)
• Gaps: 251/1015 - (24%)

  Fly   344 KWGTYFASNPGLTLIAGASLVVILGYGI--NFIEITTDPVKLWASPNSKSRLEREFF-------D 399
            |:..:.|..|...:|....:.:.|..||  || :|......|:|..|:..:.|...|       |
 Worm    21 KYCLFVAKYPWPFIIIPLIITICLSMGIILNF-KIVRGVNYLYAPLNATWKTEEAVFGENWAKDD 84

  Fly   400 TKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINANGT--QLK 462
            ..|.|    .:.|::...:..|| |..:|.......:.::|| |:||....:|.:::.|.  ..|
 Worm    85 DHFYP----GKDILRRQGIYLIV-NAKDGGNVLRQEYAQDFL-KILDWILNVKLLSSAGRIFTYK 143

  Fly   463 DICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERL-----DDHDEDNGFNVTYLDALYDCISNPY 522
            |:|....:|         |        |.:...:|     ..:.:::.||:||          |.
 Worm   144 DVCLHFQND---------C--------FSNPHAKLLANIYSKNHQNSMFNITY----------PI 181

  Fly   523 LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNH--HNKTDLENALTWEKKF 585
            ........|:|.:..||..     .|......|.|:|.::.:.:||.  ....|.|:.|..:.:.
 Worm   182 YRSTYATEPIDISKVLGNV-----SLDYDGHVENASAWLILYQLKNEKWQLSRDFEDGLAEKIQS 241

  Fly   586 VEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQ------SDVLTILVSYLIM------FMYIA 638
            .|        ..|:.:::.:....:.:.||.:|::      |...::|:.:.||      ||...
 Worm   242 GE--------APSELLNLYYFHSATFDQELEKENRRLTPKFSITFSVLIIFAIMTTFTIKFMKFK 298

  Fly   639 ISLGHVKEFKRV-FIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLI-IVEVIPFLVLAVGV 701
            ...| :.::..: ::.||..|||.||::.:.:::||.|:.....:  |.: :..|:|||.|.:|:
 Worm   299 TENG-INQYPVIDWVLSKPLLGICGVLVTMCAIISSTGLLMLFNV--TFVDMCTVMPFLSLTIGI 360

  Fly   702 DNIFILVQT-HQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALY 765
            |:.|:::.. |:.|:..|   .|:::.:.:.....|:.:|||:::..|.:|.::.:|||..|..|
 Worm   361 DDTFLMLAAWHETDRNLP---YEKRIEKAMRHAAVSISITSLTDALAFLIGSIAPLPAVIYFCYY 422

  Fly   766 AGVALIIDFLLQITCFVSLFTLDTKRREENRMDIC--------------------------CFIK 804
            :..|::..||..:|.||::..|..:|.|:.:..:.                          ..:|
 Worm   423 SSAAILFIFLYVLTMFVAVLALQGRREEDLKHSVTGMKTIDLDSDYETASTRQLLLKMGSRVSVK 487

  Fly   805 GKKPDSITSNEGLL------------YKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRI 857
            ..:.::..:||..:            .:||...|.||:....:.....:|:.|:|..:......:
 Worm   488 ADEENNNNNNEKSIENIQKIDNRMWYQRFFEDQYAPFISNSKISILSFLIYLAYLAAAFYGVKHL 552

  Fly   858 DIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLT 922
            .||.|....:.:|| ....|..:.|.|.   |....|. |:|..||.:        :.|.:
 Worm   553 KIGFDLINIVQEDS-ASRVFLEVREQLF---PEDTKLM-DIAVMNSPN--------FSNPE---- 600

  Fly   923 QIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQDTSCLRCNITKNSLLR 987
                 .|.:....::...|:|              |...::|..|...
 Worm   601 -----ERFNFMEVLSEFESTW--------------CSEGRESTQFWFF----------------- 629

  Fly   988 PEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGG-AVRYSNSHERLNIEASYFMAYH---------- 1041
                |..|||               .:..:|| ..:..||..:|:.....|:..|
 Worm   630 ----EMQKYL---------------SNLGFGGDLTKTMNSERKLSQSKKTFLMSHEKFGYDVLSD 675

  Fly  1042 ------TILK---SSADYFLALESARKIS---ANITQMLQGRLMSNGVPMASALTVEVFPYSVFY 1094
                  |.||   :..:.|....:.||:|   ||.:                     :..||..:
 Worm   676 KQFRLSTRLKNVETDEEMFNCARTMRKLSQKHANYS---------------------IITYSPLW 719

  Fly  1095 VFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLN 1159
            ...::|..||..|:|.:.||:..:..|..:.:...:.| :::.:.|..|...:.|.|.:..:||:
 Worm   720 NIADEYDIMWPQTMQDIYISIAVMVPVALLFIPQPLCS-VIIGLNIASIAFGVIGTMSFLGVSLD 783

  Fly  1160 AVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQI-------DRAADSLSKMGSSIFSGITLTKFA 1217
            |.|::.:.|:||.||:|.:|:.:::.| :|.:||       .|...:|..:|..: :..:::...
 Worm   784 ATSMITVAMSVGFSVDFAAHVSYAYMT-ESGAQIPGKSAIYSRFCHTLGTIGWPV-TQASVSVLL 846

  Fly  1218 GILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLL 1257
            |:..|....|.:.|. .||..:.:::.|..|.|:|||:||
 Worm   847 GVSSLYLVDSYVVQT-CFRTVVLVILFGTTHALVFLPLLL 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	209/1015 (21%)
ptr-17	NP_001364498.1	Patched	57..888	CDD:308203	199/978 (20%)