Protein Alignment Npc1a and PTCHD1

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: NP_775766.2
• Gene: PTCHD1 / 139411
• HGNCID: 26392
• Length: 888
• Species: Homo sapiens
• Alignment Length: 981
• Identity: 198/981 - (20%)
• Similarity: 383/981 - (39%)
• Gaps: 199/981 - (20%)

  Fly   338 LETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKF 402
            |.|.|::.|.:.||:|.....|...:.::||...:..::......|.|..:|.:::||...::.|
Human    10 LRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLF 74

  Fly   403 SPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA-----NGTQLK 462
             |..|.:..:...:..|..........:....:.|:.....:|.|...:.:|..     |.| ..
Human    75 -PVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTKIQVPRPGFNYT-FA 137

  Fly   463 DICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDN--GFNVTY-LDALYDCISNPYLC 524
            .||.  |::|      ..|:|..|....    |.|.:....|  .|.:|| :..|.|
Human   138 HICI--LNND------KTCIVDDIVHVL----EELKNARATNRTNFAITYPITHLKD-------- 182

  Fly   525 LAPYGGPVDPAIALGGFLPPGDQLTGST-----KFELANAIILTFLVKNHHNKTDLENALTWEKK 584
                          |..:..|.||.|.|     :.:.|.||.||:.:::.::..|:. |..||..
Human   183 --------------GRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMV-AERWESS 232

  Fly   585 FVEFMTNYTKNNMSQYMDIAFTSERSIED--ELNRESQSDVLTILVSYLIMFMYIAISLGHVKEF 647
            |.:.:..:.|:| |:.....:||....||  :.:|.|:    ..||:.||:.:.:||....:::.
Human   233 FCDTVRLFQKSN-SKVKMYPYTSSSLREDFQKTSRVSE----RYLVTSLILVVTMAILCCSMQDC 292

  Fly   648 KRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIG--LPATLIIVEVIPFLVLAVGVDNIFILVQT 710
            .|    ||..||:.|::.:..:.:::.|:....|  ..:|.:   .:||::|..|:...|.::.:
Human   293 VR----SKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFL---GVPFVMLGHGLYGTFEMLSS 350

  Fly   711 HQRDQRKPNETLEQQV-GRILGKVGPSMLLTSLSESFCFFLGGLSDMP-----AVRAFALYAGVA 769
                .||..|  :|.| .|.......|||..||:.:......|:...|     |.|.|...:.:|
Human   351 ----WRKTRE--DQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIA 409

  Fly   770 LIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSI----------------------- 811
            :..::|..::.:.|............:..|.| .|..||:::
Human   410 IFFNYLYVLSFYGSSLVFTGYIENNYQHSIFC-RKVPKPEALQEKPAWYRFLLTARFSEDTAEGE 473

  Fly   812 ---TSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFV 873
               |....||..|....|..::....|:..|::.:..::.|::....::..|.|....:...:..
Human   474 EANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQT 538

  Fly   874 LHYFQSLNENL-NIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVL--TQIYLASRHSNQTY 935
            :.|..:..:.. |..|.:.|.:...:.|.|:|.|           :.||  |:.::
Human   539 IEYTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQ-----------EDVLEYTKGFV--------- 583

  Fly   936 IARPASSWIDDYFDWAAAASSCCKYRKDSGDFCPHQD-TSCLRCNITKNSLLR-PEEKEFVKYLP 998
                ..||.:.|.::..      |....:|  .|.:: |..||     ||.|: |:...|.:.:.
Human   584 ----RISWFESYLNYLR------KLNVSTG--LPKKNFTDMLR-----NSFLKAPQFSHFQEDII 631

  Fly   999 FFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEAS-YFMAYHTILKSSADYFLALESARKISA 1062
            |..|.|                       :.:::.|| .|:...|:..:..:.:..||:.|::|
Human   632 FSKKYN-----------------------DEVDVVASRMFLVAKTMETNREELYDLLETLRRLS- 672

  Fly  1063 NITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMG 1127
             :|.                 .|:...::..:|:.::|.:.....|.:..||.|  |::.|  ..
Human   673 -VTS-----------------KVKFIVFNPSFVYMDRYASSLGAPLHNSCISAL--FLLFF--SA 715

  Fly  1128 FDVHSALV-VVITITMIVVNLG--GLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKS 1189
            |.|..:|: |.||:|::.|..|  |.|..|.:.|:.:|::.|:..:..:::.|:.::.:|...|.
Human   716 FLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPMLSTFVLGKD 780

  Fly  1190 VSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLP 1254
            .::.....::|...|.:|.... |....|::.||...|.:....:..::| |..:...|....||
Human   781 FTRTKWVKNALEVHGVAILQSY-LCYIVGLIPLAAVPSNLTCTLFRCLFL-IAFVTFFHCFAILP 843

  Fly  1255 VLLSYI 1260
            |:|:::
Human   844 VILTFL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	198/981 (20%)
PTCHD1	NP_775766.2	Patched	105..851	CDD:308203	179/885 (20%)