Protein Alignment Npc1a and LOC1281707

DIOPT Version :10

• Sequence 1: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Sequence 2: XP_061500628.1
• Gene: LOC1281707 / 1281707
• VectorBaseID: AGAMI1_000587
• Length: 1000
• Species: Anopheles gambiae
• Alignment Length: 1043
• Identity: 220/1043 - (21%)
• Similarity: 433/1043 - (41%)
• Gaps: 239/1043 - (22%)

  Fly   329 KLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTD--PVKLWASPNSKS 391
            :|..:....:..||.:.|.:.|:|...|:  |...:::....:.||....:  |:|||....||.
Mosquito    53 RLSYYVSMAIGKFFYRLGYWIANNAWKTI--GLCFLLVALCSVGFIRFHKEKSPMKLWIPVGSKF 115

  Fly   392 RLEREFFDTKFSPFYRLEQIIIKA--VNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEI 454
            :.:..:....|....|:|.::|.|  |.:|:::                :.:..:.:..||....
Mosquito   116 QHDTNWLIEHFKEGNRIETVMITAPDVLVPEVL----------------QTIATITEEVEGFTFH 164

  Fly   455 NANGTQL--KDICY-APL--------------SDDGSE------------------IDVSQ---- 480
            |:.|.:|  .|:|: .||              :.|..|                  |||..
Mosquito   165 NSEGQRLGWTDVCHKVPLIAEYTADLSRRKRHAQDLEEPSVTTRRPKKSKPFFTPVIDVPSFLFC 229

  Fly   481 ---------CVVQS---IWGYFGDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVD 533
                     |...|   :|.|.......|...|..:..|.|.:..:             .|..|:
Mosquito   230 PMVERLELGCYGSSLLELWKYNRTTIAGLSKEDIVDKLNRTTISPM-------------TGHTVE 281

  Fly   534 PAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTD--------------LENALTWEKK 584
            .|..||..     :...|.:...|.:::..:.|..:.::.|              .|||:.||::
Mosquito   282 FAELLGDV-----KRDWSGRIVSAGSLVTHWFVHVNFSEVDSDVSGNAAGTEDWVTENAMLWEER 341

  Fly   585 FVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQ-SDVLTILVSYLIMFMYIAISLGHVKEFK 648
            |::.:|...::..:...||.:.:.||..| ::.||. .|:..::...::||:|:.:.|.     |
Mosquito   342 FLQIVTKAKRDLSNNETDIYYAAGRSYGD-ISEESMFKDMDKLIYGGIVMFVYMQLVLS-----K 400

  Fly   649 RVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQR 713
            ..:.:.::.||..|::.|....|:..|:...:|:....:... :|||::.:|||::|:::..: |
Mosquito   401 FSWTEFRVILGSVGLMSVGMGFVAGCGIVAALGVSYGPVHTS-LPFLLMGLGVDDMFVMMACY-R 463

  Fly   714 DQRKPNETLE--QQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLL 776
            ..||.|..|:  :::|.:|...|.|:.:|||::...|.:|.::.:|::::|.:||...:.:.|:.
Mosquito   464 KVRKANPDLQLAERMGLMLQHAGASITVTSLTDIVAFIVGSITVIPSLQSFCIYAAAGVFMMFVF 528

  Fly   777 QITCFVSLFTLDTKRREENRMDICCF-IKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVM 840
            .||.||::||||..|....|.....: :..:|..|:.....|:::|.:::|..||:..:  ..|:
Mosquito   529 VITFFVAIFTLDELRIASRRNSFLLWVVHDEKSTSLWCEYNLMHRFINALYSKFLLTTV--GKVL 591

  Fly   841 VIFFAWLCFSIAIAPRIDI--GLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNS 903
            ||....|...:.:...:.:  ..|....:|::::   |.|             ||:|....|.|:
Mosquito   592 VILAVVLMTGVNVHNLLKLRQKFDPNWFIPEETY---YNQ-------------FVVKTHEHYPNA 640

  Fly   904 SDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFC 968
            ..:.::..|.......:...|.:..|..|:|.|....|||:..:.|:...     .|.||
Mosquito   641 GYEAMLLFGHLNYTAELPNLIGITHRLENRTDILHSFSSWVTAFQDFVHT-----HYDKD----- 695

  Fly   969 PHQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIE 1033
                       |..::|   .|.:|.|||..||                   ..|.....::||:
Mosquito   696 -----------IAVDAL---SEADFRKYLSKFL-------------------FSYEGGRYQMNIK 727

  Fly  1034 ASYFMAYHTILK----------SSADY----FLALESARKISANITQMLQGRLMSNGVPMASALT 1084
                  :.|.||          ::.|:    |...|........:..:|....:|.|
Mosquito   728 ------FATKLKCGQPAPNITVTTMDFKFRPFKEREEYLPAKYAVEDVLASSNISTG-------- 778

  Fly  1085 VEVFPYSVFYVFYEQYLTMWS------------DT--LQSMGISVLSIFVVTFVLMGFDVHSALV 1135
                         :.|.|:|:            ||  .:::.::::.:...:.||: .::.....
Mosquito   779 -------------DHYRTLWAKIFGNWVTDEIIDTEIYRNISLALIGVMFCSVVLI-VNLQICFW 829

  Fly  1136 VVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSL 1200
            :.:.:.:.:||:||||..|.::|:.||.:.|.:|||:.|::.:|:.|:|.|.....:..|:.:::
Mosquito   830 IFVCVLLTLVNVGGLMQVWGLTLDLVSCIALQLAVGLCVDYAAHIGHTFLTINKGDRNRRSLETV 894

  Fly  1201 SKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIG-APV 1264
            ..:|:::|.|...| ...:.:|:.:::..::.| |:::|.::..|..||.|.|||:||.|| ||.
Mosquito   895 LHIGAAVFYGGGST-ILSLSILSGSQAYTYRTF-FKIFLLVIAYGLFHGTILLPVILSLIGPAPY 957

  Fly  1265 SNA 1267
            |.:
Mosquito   958 SGS 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	215/1034 (21%)
LOC1281707	XP_061500628.1	None