DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and Npc1a

DIOPT Version :10

Sequence 1:NP_609357.2 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:XP_061516663.1 Gene:Npc1a / 1277820 VectorBaseID:AGAMI1_006685 Length:1760 Species:Anopheles gambiae


Alignment Length:1365 Identity:788/1365 - (57%)
Similarity:971/1365 - (71%) Gaps:114/1365 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 QSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLL-ENSENKF--CCDKNQ 88
            :|....|||||:||.:....:|.||||||||.:.|:..:|||..|..|| |::....  |||..|
Mosquito    66 ESGGNQCVWYGICNVDSLGRAQYCPYNGTAKAIDTEANDLLKVWCKHLLVEDATGSINTCCDAAQ 130

  Fly    89 VELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQ-------KNKKGD---- 142
            |::|||||.||.|.|.||||||.|||||:|.|||||:|:.||.||:|:       :::|.|    
Mosquito   131 VKVLNKNVALAANFLSRCPSCMANLVRHMCDFTCSPQQSSFMKVVSTEEVDQQEGESEKADATTA 195

  Fly   143 ------EYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDA 201
                  |||:.:|:||:.:|:|.|::||:|||||.|||||.|||||.:.||||:..|||.:||||
Mosquito   196 AAPSPKEYITKIDIHITQQYLNGTFESCNQVSVPSTGQLALDLMCGDWGASRCSAKKWFFYMGDA 260

  Fly   202 -TNPYVPFQITYIQH-EPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRP 264
             .|.||||||.|:.| .|....:.:.|.|...|||::.:.:..|||||.||:.|||:.|..|..|
Mosquito   261 ENNLYVPFQIDYVAHSSPNETIDGYLPWNPRIVPCSEKLDANTPACSCVDCEASCPKPPAPPGPP 325

  Fly   265 EPFKIVGLDAYFVIMAAVFLVGVLVFLMGS------------------FLFTQGSSMDDNFQVD- 310
            :||.|.|:|.|.|:|..||:|...:||:|:                  .|...|.::..:.:.. 
Mosquito   326 QPFVIYGMDGYAVVMFVVFVVCSGLFLIGACFCHSSTGTGGGSGSGAKLLVNSGDALPSDLRSSV 390

  Fly   311 ---------------GNDVSDEMPYSENDS---------------------------YFEKLGAH 333
                           |.|..|....|:..|                           |||:|||.
Mosquito   391 GRRLAGGLSSNSGDLGTDREDSPLQSKRSSATWDGEQELRPHPSGVGAADDDDDESGYFERLGAK 455

  Fly   334 TETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFF 398
            |||.||.|||.|||..|.:|.|.|:.|...:|.:|.||||:.:||:||:|||||.|:||:|||:|
Mosquito   456 TETALEHFFTAWGTTCAKHPWLVLLGGLLFIVAMGMGINFLRVTTNPVELWASPYSRSRVEREYF 520

  Fly   399 DTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIKEINA------- 456
            |:.|.||||:|||||||.|:..::||||||...|||||:|:||..|.:|||.||:|.|       
Mosquito   521 DSNFEPFYRIEQIIIKAENISNVMHNTSNGVIQFGPVFNRQFLLDVFELQEQIKKIQAVAVDGSG 585

  Fly   457 -NGT-QLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDED-NGFNVTYLDALYDCI 518
             |.| .|||||:||||.........:|||||:||||.||.:..:|.:|| .||.:.|||.|..|.
Mosquito   586 NNETIMLKDICFAPLSTGAGPTGTQECVVQSLWGYFSDDMDNFNDEEEDAQGFVINYLDKLIQCF 650

  Fly   519 SNPY--LCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENALTW 581
            .|.|  .||||||||:|||||||| :|..........:..|:|:||||||:|:|:|..|::||.|
Mosquito   651 GNYYNPACLAPYGGPIDPAIALGG-IPQPKSADEKASYAEASAVILTFLVRNYHDKNKLQSALAW 714

  Fly   582 EKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKE 646
            |.::|.||.|:|:.|||    |||||||||||||.|||||||.||||||:|||.|||||||||.:
Mosquito   715 ETEYVRFMQNWTRENMS----IAFTSERSIEDELARESQSDVSTILVSYIIMFAYIAISLGHVNQ 775

  Fly   647 FKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTH 711
            :.|..||||:|||:|||.|||||||:|||:|||||:|||||||||||||||||||||||||||||
Mosquito   776 WNRALIDSKVTLGLGGVAIVLASVVASVGIFGYIGVPATLIIVEVIPFLVLAVGVDNIFILVQTH 840

  Fly   712 QRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLL 776
            |||.:||.||..:.:|||||:||||:||||:|||.|||||||||||||||||||||:||:|||:|
Mosquito   841 QRDTKKPTETHAEHIGRILGRVGPSILLTSVSESCCFFLGGLSDMPAVRAFALYAGMALLIDFIL 905

  Fly   777 QITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSN--EGLLYKFFSSVYVPFLMKKIVRASV 839
            ||||||||..|||.|:.:||:|:.||::|.|.| :..|  ||||||||.|:||||:|:|.||.:|
Mosquito   906 QITCFVSLLALDTIRQTDNRLDVLCFLRGSKKD-MPGNIGEGLLYKFFKSIYVPFVMRKPVRVAV 969

  Fly   840 MVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSS 904
            |::||.|||.|||:||.|||||||||:||.|||||.||:.|.:.|:||||||||:|..|.|:..:
Mosquito   970 MIVFFGWLCSSIAVAPHIDIGLDQELSMPGDSFVLKYFRYLQQYLSIGPPVYFVVKNGLNYSTMN 1034

  Fly   905 DQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSGDFCP 969
            ||||:|.|||||.||:.||:|:||:....||:|||||||:|||.|| :||..||| :.::|.|||
Mosquito  1035 DQNLICGGQYCNLDSLSTQLYIASKQPQSTYLARPASSWLDDYIDW-SAAPGCCK-QWNNGSFCP 1097

  Fly   970 HQDTSCLRCNITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERL---- 1030
            ||.::|..|||:..:..||.|..|.:|:.|||:||||:.||||||||||..|:|  ..:.|    
Mosquito  1098 HQKSACGACNISMTAQKRPVESSFRQYVSFFLEDNPDEACAKAGHAAYGSGVKY--RPDALAPLY 1160

  Fly  1031 -NIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVFY 1094
             ::.||||||||||||||:||:.||.||||||||||..:...|...|...|....:|||||||||
Mosquito  1161 NDVGASYFMAYHTILKSSSDYYEALRSARKISANITSTIHANLRLQGRSEADIQQIEVFPYSVFY 1225

  Fly  1095 VFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLN 1159
            ||||||||||.|||:|||||||:||:|||:|||||:||:|||||||||||:|:|||||:|:||||
Mosquito  1226 VFYEQYLTMWPDTLKSMGISVLAIFIVTFLLMGFDIHSSLVVVITITMIVINIGGLMYHWSISLN 1290

  Fly  1160 AVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAF 1224
            ||||||||||||||||||||||||||.|...::..||||:|:|||||:|||||||||.|||||.|
Mosquito  1291 AVSLVNLVMAVGISVEFCSHLVHSFAMSVEETREKRAADALTKMGSSVFSGITLTKFGGILVLGF 1355

  Fly  1225 AKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARLRYHSQAAAE--HETALAGIL 1287
            |.||||||||||||||||:.||||||:||||||||||||::..:|..|.:.|.:  .||:|:..|
Mosquito  1356 AHSQIFQVFYFRMYLGIVLYGAAHGLVFLPVLLSYIGAPINKVKLANHRRQAMQETQETSLSTTL 1420

  Fly  1288  1287
            Mosquito  1421  1420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_609357.2 2A060601 33..1261 CDD:273337 776/1329 (58%)
Npc1aXP_061516663.1 None

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