DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and Npc1b

DIOPT Version :10

Sequence 1:NP_609357.2 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:XP_310493.6 Gene:Npc1b / 1271641 VectorBaseID:AGAMI1_014614 Length:1288 Species:Anopheles gambiae


Alignment Length:1275 Identity:558/1275 - (43%)
Similarity:792/1275 - (62%) Gaps:79/1275 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 ILIAAVLFTLIQSSKQD-------CVWYGVCNTNDFSHSQNCPYNGTAKEMATD--GLELLKKRC 71
            :|:..|:..::..:...       ||.:.||..... |:||||.....|.: ||  .:|::.:||
Mosquito    12 LLVMVVMVVVVPPAATQGEVEGYHCVMHDVCAQIGI-HAQNCPVKMAPKPL-TDAVAIEIMHRRC 74

  Fly    72 GFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQ 136
            |::....:...||..:||..::||.:.|..:..||.:|:.|::..||...|.|:|:.|:  .|..
Mosquito    75 GWMFPADDTPVCCATSQVLEMDKNFQQAEGLFSRCSTCLTNMLYSICSLACHPEQSRFL--TAYT 137

  Fly   137 KNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDA 201
            :...| .|::.||..|..:|:..|:.||..:.:|.:|:.|.|:.||.:.|:.|...:||.:||.|
Mosquito   138 EPTTG-TYVNRVDYRIDRQYVQDTFDSCKGIVLPSSGKYAMDVGCGYWEAAGCTAERWFQYMGAA 201

  Fly   202 TNPYVPFQITYI-QHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRP- 264
            .|.:|||:|.|: :.:|:..      .|.....||:|..... ||||.|||.|||..  |||:| 
Mosquito   202 DNEFVPFEINYLYEEDPEQR------FNQEVKHCNEAYDGSY-ACSCVDCDESCPTS--EPPQPK 257

  Fly   265 EPFKIVGLDAYFVIMAAVFLVG-------VLVFLMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSE 322
            :|..:|| |...|......:||       ||..|.|.   .:||             ..::|  :
Mosquito   258 DPGFMVG-DLNGVTFTVAVVVGGIGLACIVLALLFGG---KEGS-------------KQQLP--D 303

  Fly   323 NDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASP 387
            ..|:|....:.......| ||:|||:.|.||.|.|...:.:|..|.:||.::.||||||:|||:|
Mosquito   304 LPSFFGGFPSVNRALGRT-FTRWGTFCARNPVLILAICSWIVGGLAFGIQYLIITTDPVELWAAP 367

  Fly   388 NSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQEGIK 452
            :|::|.|:::||::||||||.|||.||.......:|.|:.|..||||.:|||||.:|..||..|:
Mosquito   368 DSRARQEKDYFDSRFSPFYRTEQIFIKPTRQEFFIHPTAEGNQTFGPAYDREFLLEVFKLQTTIE 432

  Fly   453 EI-NANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDED-NGFNVTYLDALY 515
            :: .:.|..|:.||:||::..|::..:|:|.|||::|||.:.....:....| |||.|.|||.:.
Mosquito   433 QLGQSEGRGLEQICFAPMTQVGAQTVLSECTVQSVFGYFKNSLAEFNRTGTDLNGFVVNYLDKIN 497

  Fly   516 DCISNPYL--CLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTDLENA 578
            .|..|.||  |...||||::|.:|:|||..|..  ..:..|.||..::|||||:|..||.:|..|
Mosquito   498 GCTRNAYLPSCFGTYGGPIEPGVAVGGFPQPAP--GANPDFRLATGVVLTFLVENKANKDELGPA 560

  Fly   579 LTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGH 643
            |.||::||:||.::.    ...|::|:::||||||.::..|::::.|:::||::||:||..|||.
Mosquito   561 LEWEQRFVDFMRDFE----HPMMEVAYSAERSIEDGIDEMSEAEMYTVIISYVVMFVYITFSLGK 621

  Fly   644 VKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILV 708
            ::.|::....|:|.|.:||:::|||||..|:|.|||:.|..|::.:||||||||||||||||:||
Mosquito   622 IRGFRQFLHGSRIVLAVGGIVVVLASVACSLGFFGYLELATTMLTIEVIPFLVLAVGVDNIFMLV 686

  Fly   709 QTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIID 773
            ....|..|:........:|..||::|||:||||.||..||.:|.||.||||..||.||.|||::|
Mosquito   687 HAFNRIDRERTPETACAIGEALGQIGPSILLTSASECCCFAIGALSPMPAVNTFAWYATVALLVD 751

  Fly   774 FLLQITCFVSLFTLDTKRREENRMD-ICCFIKGKKPDSITSNE--GLLYKFFSSVYVPFLMKKIV 835
            |||||:.||:|..||.:|.|..|:| :||....|.||...:.:  |.|.:.....|||||::..|
Mosquito   752 FLLQISAFVALMALDEQRVERGRLDLVCCVRATKNPDKPVAPDGPGWLERVVERFYVPFLLRPRV 816

  Fly   836 RASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAY 900
            |.:|:.:|..|...|:.:.|.|:.||||||:|.:||.|:.||:.:.|...:|||||||:|..|.|
Mosquito   817 RLTVLALFLVWGSLSLMVVPSIEPGLDQELSMAEDSHVVKYFRFMAELFWMGPPVYFVVKAGLNY 881

  Fly   901 TNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSG 965
            |:...|||||.|..|||||:.|::|.||.:...|:||||||||:|||.|| .|..|||||....|
Mosquito   882 TDVQHQNLVCGGILCNDDSISTKLYQASLYPETTHIARPASSWLDDYIDW-LAIQSCCKYNPTDG 945

  Fly   966 DFCPHQDTSCLRCNITKNSL-LRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHE- 1028
            .||......|..|....:.. :||...:|.:||.|||.|.||:.|||||.|||..|:.|....: 
Mosquito   946 SFCASNIVFCPACPEEYDETGIRPTVPQFERYLEFFLSDLPDENCAKAGRAAYSRALNYLLDRDG 1010

  Fly  1029 RLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVFPYSVF 1093
            |||::.|||..|||...:|..::.|||.||.|:|:|.|||..|...          ||:||||||
Mosquito  1011 RLNVQDSYFSTYHTTAVTSRQFYTALEQARLIAADIQQMLDERQAG----------VEIFPYSVF 1065

  Fly  1094 YVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYYWNISL 1158
            |||||||||:|||.|||:|:|:.::|||||::.|.|:.|||||::.:.:||:|:.|||:.|||:|
Mosquito  1066 YVFYEQYLTIWSDALQSLGLSLAAVFVVTFLVTGLDLLSALVVILLVFLIVLNMMGLMWLWNITL 1130

  Fly  1159 NAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLA 1223
            ||:|||||||:|||.|||.||:|.::..:.. ::::|:|.::.:.|||:||||||||||||:|||
Mosquito  1131 NAISLVNLVMSVGIGVEFISHIVRTYRLAHG-TRLERSAAAMVRTGSSVFSGITLTKFAGIIVLA 1194

  Fly  1224 FAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAP 1263
            ||||||||:|||||||.||::|||||||.|||.|:|||.|
Mosquito  1195 FAKSQIFQIFYFRMYLCIVLVGAAHGLILLPVFLTYIGPP 1234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_609357.2 2A060601 33..1261 CDD:273337 553/1247 (44%)
Npc1bXP_310493.6 None

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