DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and npc1l1

DIOPT Version :10

Sequence 1:NP_609357.2 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:XP_073767089.1 Gene:npc1l1 / 100616532 ZFINID:ZDB-GENE-110510-5 Length:1392 Species:Danio rerio


Alignment Length:1316 Identity:492/1316 - (37%)
Similarity:735/1316 - (55%) Gaps:97/1316 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LIAAVLFTLIQSSKQDCVWYGVCNTNDFSHSQNCPYNGTAKE------MATDGLELLKKRCGFLL 75
            |.|.::.|..|.....|..|..|..|........|.....|:      :..|..||||..|..|.
Zfish    17 LAACLVLTGAQHEPGFCAMYEDCGLNPAVEGALIPPRVPCKDYRRAVNVTGDHYELLKSVCPMLA 81

  Fly    76 E-NSENKFCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVV----AT 135
            . :.:...||...|:..|..::.|:..:|.|||||.||.....|..||||.|::.:.:.    .|
Zfish    82 NGDGQTLACCSIRQLTALQNSLSLSKAVLIRCPSCAENFAYLHCATTCSPDQSQILKITKTANIT 146

  Fly   136 QKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGD 200
            |......|.:.....:|||.:.:.::.||..|.:|.||..|...|||.|.|:.|.|.:|::|.||
Zfish   147 QPTGIVKEAVVGYAAYISTNFSDASFDSCKNVRIPSTGGFAIATMCGRYGAALCTPQRWYDFQGD 211

  Fly   201 ATNPYVPFQITYIQHEPKSNSNNFTPLNV-----TTVPCNQAVSSKLPACSCSDCDLSCPQGPPE 260
            ::|...|..|.:...:....|.  .|...     ..:.||:...|...||||.||..|||..|..
Zfish   212 SSNGLAPLDIDFKLLQDSETSE--VPAGAFAFAGQALKCNEVTPSGGEACSCQDCLQSCPVVPEP 274

  Fly   261 PPRPEPFKIVGLDAYFVIMAAVFLVGVLVFL-----------MGSFLFTQGSSMDD------NFQ 308
            ||.|:||.|..|:...||...||...:.:||           |.|....:|.|..|      .|:
Zfish   275 PPLPKPFMIGNLNGVLVICLTVFSCFLFLFLCYVITECTTYYMKSRKGRKGKSTKDQNANEIKFK 339

  Fly   309 VDGNDVSDEMPYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINF 373
            :...|||..          :|....|:.||.:.|..|||..|..|.:.|.....:|::...||..
Zfish   340 ISPKDVSCS----------DKASLATQEFLGSLFQSWGTLMARYPYIVLPVCLVIVLVFAVGIKD 394

  Fly   374 IEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNT-SNGPYTFGPVFD 437
            ||:|||||:||::|.|::..|:.|.|..|.||||..|:|:.|...|...::: ..|...|..:..
Zfish   395 IELTTDPVQLWSAPESRAMREKAFHDAHFDPFYRTNQLILTAPGRPSHFYDSLLFGKQNFSGIIS 459

  Fly   438 REFLTKVLDLQEGIK-------EINANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRE 495
            ::.:.::|.||:.|:       |:|:..: |||:|||||:.....:  :.|.|.|:..||.:..:
Zfish   460 KDLIIELLKLQQSIQAIEFWSDELNSTAS-LKDVCYAPLNPGNPSL--TDCAVNSLPQYFQNSID 521

  Fly   496 RLDDHDEDNGFNVT----YLDALYDCISNP----------YLCLAPYGGPVDPAIALGGFLPPGD 546
            .|:.........||    :.|....|:::|          ..|::.|||||.|.:|:||:     
Zfish   522 NLNAKVNMTELGVTKEVDWRDHFIYCVNSPLSFKDITALGMSCMSDYGGPVFPFLAVGGY----- 581

  Fly   547 QLTGSTKFELANAIILTFLVKNHHNKTDLENALT--WEKKFVEFMTNYTKNNMSQYMDIAFTSER 609
               .:.::..|.|:||||.: |::.:||::..:.  ||.:|::.:..|.||:.:.: ..|:.:||
Zfish   582 ---DNEQYTTAEALILTFSL-NNYARTDVKFKVVEEWENRFLKIVQEYQKNSTTNF-TFAYMAER 641

  Fly   610 SIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSV 674
            |:|||:||.:..|:...::||.::|:|||::||.....||:.:|||..:|:||:::|..||::|:
Zfish   642 SLEDEINRTTAEDIPIFMISYAVIFLYIAVALGEYSSCKRILVDSKFLVGLGGILVVGCSVIASM 706

  Fly   675 GVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLL 739
            |.:.:||:.::|:|::|:||||||||.|||||.|..:|||.|:|.|..|:|:||:||.|.|||||
Zfish   707 GFYAWIGVASSLVILQVVPFLVLAVGADNIFIFVLEYQRDLRRPGEQREEQIGRVLGNVAPSMLL 771

  Fly   740 TSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIK 804
            .|||||.|||||.||.||||::|||||.:|:::||:||:|.||:|.:||.:|::.||.:|.|.:.
Zfish   772 CSLSESVCFFLGALSTMPAVKSFALYAALAVLMDFVLQMTAFVALLSLDARRQDSNRCEIACCVT 836

  Fly   805 GKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQ 869
            ...|.....|||:|.......|.|||:....|..|||:|......|:.:...:.:||:||||||.
Zfish   837 VDTPRPQKPNEGILLPLMRKYYAPFLLNSFSRVVVMVLFLVMFFSSVFLMFHVKVGLNQELAMPT 901

  Fly   870 DSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQT 934
            ||::|.||..|.:...:|.|.||:......:.:....|.||:...|:..|:..:|..|:.:..::
Zfish   902 DSYMLDYFAYLFKYFEVGVPTYFITTKGFNFNSEEGINAVCSSVGCDQFSMTQKIRYATEYPERS 966

  Fly   935 YIARPASSWIDDYFDWAAAASSCCK---YRKDSGDFCPHQDTS-CLRCNITK--NSLLRPEEKEF 993
            |:|.|||||:|||.||....|.||:   :..:..:|||..:|. ||:..:.|  |.:|||:..||
Zfish   967 YLAIPASSWVDDYIDWLNPGSRCCRLYTFGPNKDEFCPANETGVCLKKCMGKPENGVLRPDVSEF 1031

  Fly   994 VKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERLNIEASYFMAYHTILKSSADYFLALESAR 1058
            .::||.||.:.||..|.|.|..||..||...|  |...|.|:.||||||.|.:|.:|..||:.||
Zfish  1032 NRFLPDFLSNRPDLQCPKGGLGAYDKAVIRDN--ETGEIIATRFMAYHTPLVNSQEYTGALQKAR 1094

  Fly  1059 KISANITQMLQGRLMSNGVPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTF 1123
            :::.|||..:  |.:::..|     ..|||||:|.||:|||||.:.::.|.::.:.:|..|||..
Zfish  1095 ELAHNITMAM--RKLNDTSP-----DFEVFPYTVTYVYYEQYLNIVNEGLFNIAVCLLPTFVVCC 1152

  Fly  1124 VLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSK 1188
            :|:|.|:.|..:.::||.||.|:..|:|..|.|..|||||:|||.||||||||.||...|||.|.
Zfish  1153 ILLGMDLRSGFLNLLTIVMITVDTVGVMTLWGIDFNAVSLINLVTAVGISVEFVSHTTRSFALSV 1217

  Fly  1189 SVSQIDRAADSLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFL 1253
            ..::::||.::.:.|||::|:|:.:|...||:||||||:|:.|:|:||:.|.|.::|.|||||||
Zfish  1218 RPTKVERAKEATANMGSAVFAGVAMTNLPGIVVLAFAKAQLIQIFFFRLNLVITLLGMAHGLIFL 1282

  Fly  1254 PVLLSYIGAPVSNARL 1269
            ||||||.|..|:||.|
Zfish  1283 PVLLSYFGPGVNNALL 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_609357.2 2A060601 33..1261 CDD:273337 483/1290 (37%)
npc1l1XP_073767089.1 None

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