DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Npc1a and npc1

DIOPT Version :9

Sequence 1:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:XP_004915269.2 Gene:npc1 / 100494646 XenbaseID:XB-GENE-984654 Length:1283 Species:Xenopus tropicalis


Alignment Length:1293 Identity:564/1293 - (43%)
Similarity:803/1293 - (62%) Gaps:90/1293 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SKQDCVWYGVCNTNDFSHSQ-NCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELL 92
            |.|.|||||.|..:.....: ||.|:|....:..:|..||::.|..|...: |..|||..|:..|
 Frog    25 SSQHCVWYGECGNSTLEDKRLNCRYSGPPISLPEEGHTLLQQLCPSLYYGN-NTVCCDVQQLNTL 88

  Fly    93 NKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQ-----KNKKGDEYISSVDLHI 152
            |.|::|....|.|||||..|.:...|:.||||.|:||::|..|:     ..::.:|.|.:::.:|
 Frog    89 NSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPHQSEFLNVTQTEPFVGPSPQRANESIVAMEYYI 153

  Fly   153 STEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNPTKWFNFMGDATNPYVPFQITYIQHEP 217
            ..::.|..|.:|..|..|.:...|..|:||. ....||.|.|..:|....|..|||.||.|..:.
 Frog   154 GEQFANAMYNACKDVEAPSSNVKALALLCGK-DVKDCNATNWIQYMFSKDNGQVPFTITPIFSDD 217

  Fly   218 KSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGLDAYFVIMAAV 282
            ...|  ..|:|..|..|::.|.....:|||.||.|||...|..||.|.|:.|.||||..|||..|
 Frog   218 PVTS--MLPMNNATKGCDEPVEEGGASCSCQDCALSCGPVPQPPPLPPPWLIFGLDAMAVIMWIV 280

  Fly   283 FLVGVLVF---LMGSFLFTQGSSMDDNFQVDGNDVSDEMPYSEND-------SYFEKLGAHTETF 337
            ::|.:|:|   ::||:.:.:.:.:.:...:|..     :.||.|.       |..::||...|.|
 Frog   281 YVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDST-----LAYSVNSTPIAGEPSCCDRLGERLENF 340

  Fly   338 LETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKF 402
            |...|||||:.....|.:.:.....|:||..:|:.::.||||||:||:.|:|::|.|:|:||:.|
 Frog   341 LRIGFTKWGSICVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELWSDPHSQARQEKEYFDSHF 405

  Fly   403 SPFYRLEQIIIKAVNLPQIVHNTSNGPY------TFGPVFDREFLTKVLDLQEGIKEINA---NG 458
            .||:|.||:||.|.|  ..|||.|  ||      .|||..|...|.:||:||.||:.:.|   |.
 Frog   406 GPFFRTEQLIITAPN--SSVHNYS--PYPSGSDVPFGPPLDFNILAQVLELQNGIENLKAYYNNE 466

  Fly   459 T-QLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDDHDEDNGFNVTYLD----ALYDCI 518
            | .|||||.|||:...     :.|.:.|:..||.:....|:...:|:.:  .|.|    .|| |:
 Frog   467 TVMLKDICLAPLAPYN-----NNCTIFSVLNYFQNSFSVLNHSIQDDFY--VYADYHTHFLY-CV 523

  Fly   519 SNPYL----------CLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKT 573
            .:|..          ||..:|||:.|.:.|||:        ....:..|.|:::||.|.|..|.|
 Frog   524 RSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY--------DDENYNNATALVITFPVNNFRNDT 580

  Fly   574 D-LENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYI 637
            : |..|..||.:|::|:.||:..|:|    |:|::|||||||:||||:|||.|:::||.:||:||
 Frog   581 EKLNRAKAWELEFIKFVENYSNPNLS----ISFSAERSIEDEINRESKSDVTTVVISYALMFVYI 641

  Fly   638 AISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVD 702
            :::||.:.....:.:||||:|||.|::|||:||..|:|:|.|.|:..|||::|||||||||||||
 Frog   642 SLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVLAVGVD 706

  Fly   703 NIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAG 767
            ||:|:||.:|||:|..:|||:||:|||||.|.||:.|::.:|:..||||.||.|||||.|:|:||
 Frog   707 NIYIIVQRYQRDERLHDETLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAG 771

  Fly   768 VALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPDSITSN-EGLLYKFFSSVYVPFLM 831
            :|:.:|||||||||:||.:||.:|:|:||:||.|.:.|.|.:..|.. :..|:.||..:|.|.||
 Frog   772 MAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCVPGCKRNRGTDKPKSWLFLFFKKLYAPVLM 836

  Fly   832 KKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKG 896
            |..:|..|:.:|...|.||||:..:::|||||.|:||.||::|.||.||:..|:.|||||||::.
 Frog   837 KDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTYLHTGPPVYFVVEE 901

  Fly   897 DLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWAAAASSCCKYR 961
            ...||....|:.||.|..||::|::.:||.|:..||.|.|....||||||||||....|:||:..
 Frog   902 GHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISNYTRIGYAPSSWIDDYFDWVKPQSTCCRIY 966

  Fly   962 KDSGDFCPHQ--DTSCLRC-NITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRY 1023
            .::..||...  :.|||.| :.|.....:|..::|:.:||.||.|||:..|.|.||||||.||..
 Frog   967 NNTDQFCNASVVNASCLSCRSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKCGKGGHAAYGSAVDL 1031

  Fly  1024 SNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMASALTVEVF 1088
            .:|:  .|:.|:|||.||||||:|.|:..|:..||.|:.|||..:.       :|   ....:||
 Frog  1032 LDSN--TNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNITDNMD-------IP---GKKYKVF 1084

  Fly  1089 PYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGGLMYY 1153
            |||:||||||||||:..||:.::.:|:.::|.||.:|:||::.||:::.|||:||:||:.|:|:.
 Frog  1085 PYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISMILVNMFGVMWL 1149

  Fly  1154 WNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTKFAG 1218
            |.|||||||||||||:.|||||||||:..:|:.|...:::.||.|:|:.||||:|||||||||.|
 Frog  1150 WGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSVFSGITLTKFVG 1214

  Fly  1219 ILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNARLRYHSQAA 1276
            |.||..:|||||::|||||||.:|::|||||||||||||||:|..|:.|:::...|.|
 Frog  1215 IGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLGPQVNKAKVQAALQRA 1272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023 88/248 (35%)
2A060601 33..1261 CDD:273337 557/1272 (44%)
Sterol-sensing 651..804 CDD:289145 94/152 (62%)
npc1XP_004915269.2 2A060601 29..1257 CDD:273337 557/1272 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 167 1.000 Domainoid score I3809
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H228
Inparanoid 1 1.050 1028 1.000 Inparanoid score I276
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D31089at33208
OrthoFinder 1 1.000 - - FOG0001659
OrthoInspector 1 1.000 - - oto104284
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X943
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

Return to query results.
Submit another query.