DRSC/TRiP Functional Genomics Resources

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Protein Alignment Npc1a and scap

DIOPT Version :9

Sequence 1:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster
Sequence 2:NP_001120162.1 Gene:scap / 100145201 XenbaseID:XB-GENE-996521 Length:1319 Species:Xenopus tropicalis


Alignment Length:498 Identity:101/498 - (20%)
Similarity:195/498 - (39%) Gaps:112/498 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 FTKWGTYFASNPGLTLIAGASLVVILGY--------GINFIEITTDPVKLWA----SPNSKSRLE 394
            |...|...||.|...:|..|..::...|        |...:|..| ||:.::    .|:.:...:
 Frog    15 FYSHGLLCASYPIPIIILTALCILASCYPLLKLPLPGTGPVEYVT-PVRDYSPPPLEPSPEDHSD 78

  Fly   395 REFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREF---------LTKVLDLQEG 450
            |..:.... |...::|:::|||..|                :|::|         |::|..|.|.
 Frog    79 RPDWYVGL-PVSYIQQVLVKAVVSP----------------WDKDFLAVDVFRSPLSRVFPLVEE 126

  Fly   451 IK----EINANGTQLKDIC---------YAPLSDDGSEIDVSQCVVQSIWGYFGDDRER------ 496
            |:    ...:....|:|:|         ...|.|   ::....|::.|...::.:.:|.      
 Frog   127 IRNHVLREKSQEKSLEDVCLQVTDLLPGLKKLRD---KLPEHGCLLLSPANFWQNSQEHFSGDPD 188

  Fly   497 ----LDDHDEDN-GFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTGSTKFEL 556
                :..|:... ..:.|..|.|:..                          ||.| :|.:.:..
 Frog   189 LIRTIHQHEPKTLQTSATLKDLLFGV--------------------------PGKQ-SGVSLYNR 226

  Fly   557 ANAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQY-MDIAFTSERSIEDELNRESQ 620
            ...:.....:..|.......|:|....|.....||  .:..||: :.:.|..|..|         
 Frog   227 KRIVSYAITIALHRYDATFLNSLRSRLKQQHPSTN--SSAPSQHIVHVHFKEEIGI--------- 280

  Fly   621 SDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPAT 685
            ::::.::.:|:|:|.||..|...:.     .:.||..|.:..|:.||:|::.|||:....||..|
 Frog   281 AELIPLVTTYIILFAYIYFSTRKID-----LVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPT 340

  Fly   686 LIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFL 750
            |...|:.|:||:.:|::|:.:|  |........:..::.::.:.|......::....:|.....:
 Frog   341 LNGGEIFPYLVVVIGLENVLVL--TKSVVSTPVDLEVKLRIAQGLSNESWFIMKNMATELGIILI 403

  Fly   751 GGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRRE 793
            |..:.:||::.|.|:|.|.|:.||.||:..|.::.::|.:|.|
 Frog   404 GYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRME 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023
2A060601 33..1261 CDD:273337 101/498 (20%)
Sterol-sensing 651..804 CDD:289145 40/143 (28%)
scapNP_001120162.1 2A060601 <11..>446 CDD:273337 100/496 (20%)
Sterol-sensing 306..452 CDD:372063 40/143 (28%)
WD40 795..826 CDD:197651
WD40 <993..1195 CDD:225201
WD40 repeat 1050..1086 CDD:293791
WD40 1118..>1275 CDD:392136
WD40 repeat 1123..1157 CDD:293791
WD40 repeat 1162..1197 CDD:293791
WD40 repeat 1204..1237 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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