DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGAP40 and cv-c

DIOPT Version :9

Sequence 1:	NP_001157903.1	Gene:	ARHGAP40 / 343578	HGNCID:	16226	Length:	674	Species:	Homo sapiens
Sequence 2:	NP_001097786.1	Gene:	cv-c / 41749	FlyBaseID:	FBgn0285955	Length:	2351	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	131/572 - (22%)
Similarity:	222/572 - (38%)	Gaps:	135/572 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    17 PGPLA-SPCPRIPRARIARRCAQRWADLGCSSGPSSGRMDQLP--QKNLL---RLHPAGSAGCST 75
            |.|.| ||....|:|                  |..|...::|  ..|.|   |..|..:.....
  Fly  1613 PSPSALSPMHTFPKA------------------PFFGNDLKVPSHSDNFLSPNRSSPKRTPTTPR 1659

Human    76 GVESSSMDGFWMEVEQIQQ--RDEL------REEDSGGNEGQLPEGEAESQWLQDTGLSGLLGGL 132
            .:.:|.:..|...:.|:::  .|:.      .:|.|.|.:..|.:.....::||.||....:|..
  Fly  1660 SMRTSPLHFFSSPMSQLKEGKSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTGKVDDIGAH 1724

Human   133 GLDGDHQ--ELL-----STLTQTQVAAVCR-----------RLDIYARSVRRQHKTPVRDVRDVF 179
            .....||  :||     |..|:.:|..:.|           :.|.:..|..|...|..::.::
  Fly  1725 SDSECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGKDPKKRDGFRSSSFRSRSTSRKEAKN-- 1787

Human   180 GVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFNMDSAYSEQAAVLLQRS 244
                         |....||..:.|:.:.|..           |..:|.|:             .
  Fly  1788 -------------DEDTAGATTNGGSKRQPVV-----------RWHSFQME-------------E 1815

Human   245 RPSRGGTSAWGKCSLPKFTVPKGRLGVTRIGDLSLQDMRKVPSLALIELTA----LCDI------ 299
            ||:    ..:.||...|....:...|......:|...::.:..|||:.||.    .|..
  Fly  1816 RPN----MIFRKCFSKKIEPLQEDAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWN 1876

Human   300 --LGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGIL 362
              |...:|:.|...:|  :.::|||||..:|:...:.|     ||.::|....|:...||..||.
  Fly  1877 WELPKFIKKIKMPDYK--DKKVFGVPLLMILQRSGQTL-----PLAVRAAFRWLQLNALDQVGIF 1934

Human   363 RVPGSQARVKGLEQKLE-RDFYA---GLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF-A 422
            |..|.::|:..|.:::| .|..|   .:|...:.:  |.:|:||::.|:||..|||.:....| |
  Fly  1935 RKSGGKSRIMKLREQIEVTDSTAECMDVFDLQQAY--DVADMLKQYFRELPESLLTTKMSETFVA 1997

Human   423 VVPNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLF-- 485
            :..::| .:.||..:...:|:||:.||..|..|||||..|.|..|.|:||..|:...:|.::|
  Fly  1998 IFQHLP-AEVRLDAVQCAVLLLPDENREILYVLLEFLTIVAANSQQNQMTSNNLGVCLAQSIFHS 2061

Human   486 -------------LHQGRPPKLPKGKEKQLAEGAAEVVQIMVHYQDLLWTVA 524
                         ..:|:...:|..||...|:.:.|.:..|:.:...::|.|
  Fly  2062 SISTGSASVSASPRRKGKGSGMPDMKELAEAKASHECLSFMIEHYKQIYTAA 2113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP40	NP_001157903.1	RhoGAP	319..532	CDD:295372	67/226 (30%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937
		RhoGAP_DLC1	1893..2116	CDD:239840	67/229 (29%)
		SRPBCC	2148..2343	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810