DRSC/TRiP Functional Genomics Resources

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Protein Alignment ath and DHX34

DIOPT Version :10

Sequence 1:NP_609356.2 Gene:ath / 34357 FlyBaseID:FBgn0032194 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_055496.2 Gene:DHX34 / 9704 HGNCID:16719 Length:1143 Species:Homo sapiens


Alignment Length:632 Identity:215/632 - (34%)
Similarity:332/632 - (52%) Gaps:58/632 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TSRNDAVGPSPVKFS------FKRKYD------------AMANSPILEK---KPHVAQIKQTIAP 51
            |||.:...|...|.|      ..|.||            |...|..|.:   ...||:.::.:..
Human    75 TSRKEEKDPGQPKHSIPALADLPRTYDPRYRINLSVLGPATRGSQGLGRHLPAERVAEFRRALLH 139

  Fly    52 IL------LTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGY 110
            .|      ...:...:::::.:||:....:|||:.|:.:..|::..:||.||:||:||:||.||:
Human   140 YLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLKEHQVVVVAGDTGCGKSTQVPQYLLAAGF 204

  Fly   111 AKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIK 175
            :.   :..|||||:|.|::|:||..|.....|..|||.:|||...|.||||.|||.|:|||:..:
Human   205 SH---VACTQPRRIACISLAKRVGFESLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQR 266

  Fly   176 DRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NC 239
            :..|.:|.|:|:||.|||.::.|.|.|::     :|......:|||::.|||::|..|.:|| |.
Human   267 EPSLPQYEVLIVDEVHERHLHNDFLLGVL-----QRLLPTRPDLKVILMSATINISLFSSYFSNA 326

  Fly   240 KGMYLEGRTYPVRVMHTKEEHEDYI--------HTVLVTLFHI-HRTTPKNH-DVLIFLTGQEEI 294
            ..:.:.||.:|:.|::..:|.|...        ...|..|..| |:..|:.. |:|:||:|..||
Human   327 PVVQVPGRLFPITVVYQPQEAEPTTSKSEKLDPRPFLRVLESIDHKYPPEERGDLLVFLSGMAEI 391

  Fly   295 ESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGI 359
            .:    :.:.|:...:.|....|..|::.||...|.:.|...|..|||.||:|||||||:||.||
Human   392 SA----VLEAAQTYASHTQRWVVLPLHSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGI 452

  Fly   360 RCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQ 424
            |.|:|.|.|||.|::....|..|:...||:|.|.||.|||||...|.|:|.|.:::.|:||....
Human   453 RFVVDSGKVKEMSYDPQAKLQRLQEFWISQASAEQRKGRAGRTGPGVCFRLYAESDYDAFAPYPV 517

  Fly   425 PEILRTNPTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQM 488
            |||.|....|:|||:.::.: |...|.|::||....|.:|...|...||:.:.:  .:||:|..:
Human   518 PEIRRVALDSLVLQMKSMSVGDPRTFPFIEPPPPASLETAILYLRDQGALDSSE--ALTPIGSLL 580

  Fly   489 VQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTL 553
            .|.|:|....|:|:..|.|..:|.:|::.:.||....|..:::.:...|.|....:|..||..||
Human   581 AQLPVDVVIGKMLILGSMFSLVEPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTL 645

  Fly   554 LNVFNGF--LKSEK---PKMWCHDNYLNLRSLTYARNVRRQLREISE 595
            .||||.:  :|||:   .:.||....:....|....|:|||.:|:.|
Human   646 FNVFNAWVQVKSERSRNSRKWCRRRGIEEHRLYEMANLRRQFKELLE 692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
athNP_609356.2 HrpA 67..>686 CDD:441249 200/546 (37%)
DHX34NP_055496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 75..94 6/18 (33%)
HrpA 160..>624 CDD:441249 177/477 (37%)
DEAH box 279..282 2/2 (100%)
Negatively regulates interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 701..955
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..766
OB_NTP_bind 800..911 CDD:400182
Required for phosphorylation of UPF1. Not required for interaction with UPF1. /evidence=ECO:0000269|PubMed:26841701 810..1143
Required for the interaction with SMG1 and subsequent phosphorylation of UPF1. /evidence=ECO:0000269|PubMed:26841701 957..1143
Blue background indicates that the domain is not in the aligned region.

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