Protein Alignment ath and PRP22

DIOPT Version :10

• Sequence 1: NP_609356.2
• Gene: ath / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_010929.3
• Gene: PRP22 / 856732
• SGDID: S000000815
• Length: 1145
• Species: Saccharomyces cerevisiae
• Alignment Length: 676
• Identity: 271/676 - (40%)
• Similarity: 404/676 - (59%)
• Gaps: 32/676 - (4%)

  Fly    32 NSPILEKKPHVAQIKQTIAPILLT-------------SKRTS--IEQQQKSLPVFNCRHRILKEL 81
            :.|...||....:|:.....:::|             .||||  |..|:::|||:..|..:::.:
Yeast   432 DDPTKNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAV 496

  Fly    82 EANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVG 146
            ..|..::|:.||||||||||.|:|...|::..||||.||||||||::||:|||:|:...:|..||
Yeast   497 RDNQFLVIVGETGSGKTTQITQYLDEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVG 561

  Fly   147 YTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKER 211
            ||:||||||...|:|:::|||:|.||::.|..:.|||||:|||||||||..|:||.::|.|..:|
Yeast   562 YTIRFEDVTGPDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKR 626

  Fly   212 RKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIH 275
                 ..|||:|||||::...|..|| ||..:.:.|:|:||.|::::....|||...|..:..||
Yeast   627 -----PELKVIVTSATLNSAKFSEYFLNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIH 686

  Fly   276 RTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTT--DLRVFTLYAQLSQGKQLECFVPTPA 338
            ...... |:|:||||||||:|..:.:..  ::.|.|.:  :|.:..:|:.|....|.:.|.|||.
Yeast   687 INEGPG-DILVFLTGQEEIDSCCEILYD--RVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPK 748

  Fly   339 NVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDA 403
            ..|||:.|||||||||||.||..|:|.||.|...:|...|::.|....||:|||.||.|||||..
Yeast   749 GSRKVVFATNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTG 813

  Fly   404 DGTCYRAYTK-AEMDSFADATQPEILRTNPTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKS 466
            .|.|||.||: |..:...:.|.|||.|.|.:..:|.|.|:.| |...|||:|||.::.:.:|...
Yeast   814 PGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNLMLNALTE 878

  Fly   467 LDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSE 531
            |..|.::  .|:..:|.||::|..:|:||..|:.||::....|.:||::::|:||..:||....:
Yeast   879 LYHLQSL--DDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKD 941

  Fly   532 KNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEH 596
            :...|....|||...:|||||||||:..:.::...:.:|..|:|:.|.|..||:|:.|:..|.:.
Yeast   942 RQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKK 1006

  Fly   597 LHLALNS-SDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFT 660
            :.|.|.| ..|.::::|..::|||.|.|.......|.|.:|.....|||||.|:|| :..|:::.
Yeast  1007 IGLKLISCHSDPDLIRKTFVSGFFMNAAKRDSQVGYKTINGGTEVGIHPSSSLYGK-EYEYVMYH 1070

  Fly   661 EIVQTEQTFLRQVTEISIEWIKEVVP 686
            .||.|.:.::.|||.|..:|:.||.|
Yeast  1071 SIVLTSREYMSQVTSIEPQWLLEVAP 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ath	NP_609356.2	HrpA	67..>686	CDD:441249	259/624 (42%)
PRP22	NP_010929.3	GH2_like	<12..58	CDD:425380
		GH2_like	75..136	CDD:409667
		S1_DHX8_helicase	178..257	CDD:240189
		HrpA	483..>1097	CDD:441249	260/625 (42%)