Protein Alignment ath and DHR2

DIOPT Version :10

• Sequence 1: NP_609356.2
• Gene: ath / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_012845.1
• Gene: DHR2 / 853784
• SGDID: S000001561
• Length: 735
• Species: Saccharomyces cerevisiae
• Alignment Length: 696
• Identity: 238/696 - (34%)
• Similarity: 383/696 - (55%)
• Gaps: 44/696 - (6%)

  Fly    19 VKFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEA 83
            |||:...:.|.:::.  ...|.:|...|.      |.|:.:.:.:.:::|||:..:..|:..:|:
Yeast    40 VKFNDSGEGDHVSDQ--RSNKENVLTYKS------LKSRASDLLKMRETLPVYQHKREIMSYIES 96

  Fly    84 NDTVLIMSETGSGKTTQIPQFLL--LAGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVG 146
            |...:::.||||||:||||||:|  |....|:|.|.:|||||||||.:|.|||||....:|:.||
Yeast    97 NPVTVLIGETGSGKSTQIPQFVLEKLYDTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQVG 161

  Fly   147 YTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKER 211
            |:|||::.|:..|::::||||:||||.:.:..|.:||||::||||||||..||:.|.:|...:..
Yeast   162 YSVRFDNTTTTRTRLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQGP 226

  Fly   212 RKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIH 275
            |    .:|:::|.|||:..:.|..:| |...:::|||.:.|:..:.|...:|.:..|:.....|:
Yeast   227 R----PDLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLKAPTDDIVDAVIRCCIQIN 287

  Fly   276 RTTPKNHDVLIFLTGQEEIESLAQQIRQLAK-IDTTGTTDLRV-FTLYAQLSQGKQLECFVPTPA 338
            :..... |:|.||.|||||:.....:.::|| :.......|.| :.|||.|...:|...|.|...
Yeast   288 QGEELG-DILCFLPGQEEIDKAVTIMEKIAKYVSDEAPVPLIVPYPLYAALPAVQQSLVFAPIKG 351

  Fly   339 NVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDA 403
            ..|||:.:|||||||:||.|::.|:|.|..|.|.:....||..|.:|.||:|.|.||:|||||::
Yeast   352 FKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQRSGRAGRES 416

  Fly   404 DGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKSL 467
            :|..:|.|.:::.......::|||.|::.||.||.|....: |..|:.:.:.|.::.:....:.|
Yeast   417 EGKSFRLYCESDYVKLPKQSEPEIARSDVTSPVLMLKRYGVDDLLNWTWFENPGKEAIVMGLQEL 481

  Fly   468 DALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNS-- 530
            ..|||:.|  ...||..|:||...||.|..|.:|:.||..||:.:::.:||.||.:::.::.|
Yeast   482 YELGALDT--RGKITKRGQQMALLPLQPHLSSVLIKASEVGCLSQVIDIVSCLSVENLLLNPSPE 544

  Fly   531 EKNEM--AALAHAKFQSKHGDHLTLLNVFNGFL--------KSEKPKMWCHDNYLNLRSLTYARN 585
            |::|:  ..|:......::||.:.|..:|:.:.        .|.:...||....:::|.......
Yeast   545 ERDEVNERRLSLCNAGKRYGDLIMLKELFDIYFYELGKSQDASSERNDWCKGLCISIRGFKNVIR 609

  Fly   586 VRRQLREISEHLHLALNSSDD-----------IEMLKKCILNGFFENIAVLQRDGFYITASGNIR 639
            ||.|||...:.|..:::..|:           |..:.||.|.||.:|.|:...|..|.|.|....
Yeast   610 VRDQLRVYCKRLFSSISEEDEESKKIGEDGELISKILKCFLTGFIKNTAIGMPDRSYRTVSTGEP 674

  Fly   640 SKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVV 685
            ..|||||:|........|::||.|.|.:.:.|.|:.|.:.|::|||
Yeast   675 ISIHPSSMLFMNKSCPGIMYTEYVFTTKGYARNVSRIELSWLQEVV 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ath	NP_609356.2	HrpA	67..>686	CDD:441249	229/648 (35%)
DHR2	NP_012845.1	HrpA	79..>534	CDD:441249	179/461 (39%)
		OB_NTP_bind	645..722	CDD:400182	29/76 (38%)