DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and PRP43

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_011395.1	Gene:	PRP43 / 852757	SGDID:	S000003088	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	657	Identity:	265/657 - (40%)
Similarity:	396/657 - (60%)	Gaps:	38/657 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 TSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLL--AGYAKNGMIG 117
            |.|...|.:.::.|||...|...||..:.|..::.:.|||||||||||||:|.  ..:.:|..:.
Yeast    80 TPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVA 144

  Fly   118 ITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKY 182
            .||||||||::||:|||:|::..:|:.|||::|||:.||..|.::::|||:||||:::|..|.:|
Yeast   145 CTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRY 209

  Fly   183 SVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMYLEG 246
            |.||||||||||:..|:|.|::|...|.|     .:||:::.|||:|.:.|..||| ...:.:.|
Yeast   210 SCIILDEAHERTLATDILMGLLKQVVKRR-----PDLKIIIMSATLDAEKFQRYFNDAPLLAVPG 269

  Fly   247 RTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIR----QLAKI 307
            |||||.:.:|.|...||:.:.:.|:..|| .|.:..|:|:||||::|||...::|.    ||.:.
Yeast   270 RTYPVELYYTPEFQRDYLDSAIRTVLQIH-ATEEAGDILLFLTGEDEIEDAVRKISLEGDQLVRE 333

  Fly   308 DTTGTTDLRVFTLYAQLSQGKQLECFVPTPAN-----VRKVILATNIAETSITIPGIRCVIDCGF 367
            :  |...|.|:.||..|...:|...|.|.|.:     .|||:::|||||||:||.||..|:|.||
Yeast   334 E--GCGPLSVYPLYGSLPPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGF 396

  Fly   368 VKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYT-KAEMDSFADATQPEILRTN 431
            .|:|.:|....::.|....||||.|.||||||||...|.|:|.|| :|......:.:.|||||:|
Yeast   397 SKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKELIEQSYPEILRSN 461

  Fly   432 PTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDP 495
            .:|.||:|..|.| |..:|||:|||..:.:..|.:.|:.|..:  .|:..:|||||...|:||||
Yeast   462 LSSTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACL--DDEGNLTPLGRLASQFPLDP 524

  Fly   496 KYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGF 560
            ..:.:|:.:..|.|.:|||::|::||..:||:..::..:.|..|...|....|||:|||||::.|
Yeast   525 MLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKKRADDAKNIFAHPDGDHITLLNVYHAF 589

  Fly   561 LKSEKPK----MWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSD-----DIEMLKKCILN 616
            ...|..:    .||.|:|||.|||:.|.|:|.||..:....:|.||::|     ..:.::|.:.:
Yeast   590 KSDEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNTTDYESPKYFDNIRKALAS 654

  Fly   617 GFFENIAVLQRDGF--YITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIE 679
            |||..:| .:|.|.  |||...|....||||:||  .:...::::.|.|.|.:.::|.||.:..|
Yeast   655 GFFMQVA-KKRSGAKGYITVKDNQDVLIHPSTVL--GHDAEWVIYNEFVLTSKNYIRTVTSVRPE 716

  Fly   680 WIKEVVP 686
            |:.|:.|
Yeast   717 WLIEIAP 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
PRP43	NP_011395.1	HrpA	55..753	CDD:224557	265/657 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720