DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and dhx33

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	687	Identity:	319/687 - (46%)
Similarity:	441/687 - (64%)	Gaps:	41/687 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PSPVKFSFKRKYDAMANSPI--LEKKP--------HVAQIKQTIAPILLTSKRTSIEQQQKSLPV 70
            |.|.| .||      ..||.  |:|||        |.|               ..:|.|::.||:
Zfish     7 PPPAK-RFK------PGSPFFRLDKKPGMLLPRAGHAA---------------AGVEAQRRHLPI 49

  Fly    71 FNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGITQPRRVAAITVARRVAQ 135
            :..|.:::.:|....:.:.:.||||||||||||:|..||..:.|:|.||||||||||::|.|||:
Zfish    50 YQSRTQVISQLRQLHSAVFIGETGSGKTTQIPQYLYEAGIGRQGIIAITQPRRVAAISLAGRVAE 114

  Fly   136 ELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLL 200
            |....:|..||||||||||||..||::|:|||:||||:|.|.|||:|:|:||||||||||:.|:|
Zfish   115 EKKVQLGKLVGYTVRFEDVTSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEAHERTVHTDVL 179

  Fly   201 FGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMYLEGRTYPVRVMHTKEEHEDYI 264
            ||:||.||:.|.:|....|||||.|||||:|.|..||| ...:|||||.:|:::.:||:...||:
Zfish   180 FGVVKAAQRRRLEQNKIPLKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQIYYTKQPQSDYL 244

  Fly   265 HTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAK--IDTTGTTDLRVFTLYAQLSQG 327
            ...||::|.||:..|.:||:|:|||||||||:||:..|.::|  .||:|:  :.|..|||.|...
Zfish   245 QAALVSIFQIHQEAPSSHDILVFLTGQEEIEALARTCRDISKHLPDTSGS--MTVVPLYASLPPA 307

  Fly   328 KQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQA 392
            :|:..|:|.|...|||||:||||||||||.||:.|||.|.||.|.||...||:||...|:|||||
Zfish   308 QQMRVFLPAPKGSRKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGLEVLAVQRVSKAQA 372

  Fly   393 WQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDI-DCNNFDFLDPPL 456
            |||||||||:..|:|||.||:.|.::.|:.|.|||.|.|..|:|||||||.: |..||||:..|.
Zfish   373 WQRAGRAGREDAGSCYRLYTEDEFENLANMTVPEIQRCNLASVVLQLLALGVPDVLNFDFVSKPS 437

  Fly   457 EDGLRSAYKSLDALGAIKTGDDSY-ITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVL 520
            .:.:|:|.:.|..|||:...||.. :||||::|..:||:|::||.||.:..|.|.||||:::|:|
Zfish   438 PESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTLLISPDFSCTEEILTIISLL 502

  Fly   521 SSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARN 585
            |.|.|..:...:.:.......||.|..|||:||||::..|.|....|.||.:|::|.|::.....
Zfish   503 SVDSVLYNPPARRDEVISVRKKFISSEGDHITLLNIYRAFKKVSGNKDWCRENFVNSRNMGLVGE 567

  Fly   586 VRRQLREISEHLHLALNSS-DDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLH 649
            ||.|||:|...::|.|.|| .|:..:::|:.:|.|.:.|.||.||.|:....:....|||||||.
Zfish   568 VRAQLRDICIKMNLKLESSVCDLANVRRCLAHGLFMSAAELQPDGSYVALDTHQPVSIHPSSVLF 632

  Fly   650 GKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
             :.:|..:||.|::.|.:.::|.:..|..:|:.|..|
Zfish   633 -QARPVCVLFNELLHTSRCYMRDLCLIQTDWLHEAAP 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	105/183 (57%)
		DEXDc	64..207	CDD:238005	89/142 (63%)
		Helicase_C	264..381	CDD:278689	69/118 (58%)
		HA2	451..536	CDD:214852	35/84 (42%)
		OB_NTP_bind	570..670	CDD:285018	35/100 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579511
Domainoid	1	1.000	138	1.000	Domainoid score	I4838
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56235
Inparanoid	1	1.050	581	1.000	Inparanoid score	I983
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D136652at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto38691
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5648
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810