DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and ythdc2

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_004910524.1	Gene:	ythdc2 / 779469	XenbaseID:	XB-GENE-5881731	Length:	1457	Species:	Xenopus tropicalis

Alignment Length:	872	Identity:	224/872 - (25%)
Similarity:	345/872 - (39%)	Gaps:	281/872 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGM---IGITQPRRVAA 126
            ::|||||..:..|::.::.|..|||:.||||||||||||| :|....|||:   |..|||||:||
Frog   220 RQSLPVFEKQEDIIRIIKNNKVVLIVGETGSGKTTQIPQF-ILDNCQKNGLPCRIFCTQPRRLAA 283

  Fly   127 ITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESI-KDRLLLKYSVIILDEA 190
            |:||.|||.|....||..|||.:|.|...|..|.:.|.|:|||||..: .|..|...:.||:||.
Frog   284 ISVAERVAAERGEIIGQCVGYQIRLESRVSPKTLLTFCTNGVLLRTLMGGDSTLSAITHIIVDEV 348

  Fly   191 HERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVM 254
            |||...:|.|...::||.:|.     ..||::::||.:|::.|..|| .|..:|::||.:.|:.|
Frog   349 HERDRFSDFLLTKLRDAIQEH-----PTLKLILSSAALDVNLFIRYFGGCPVIYIQGRPFEVKEM 408

  Fly   255 H-------------------------------------------------------TKEEHE--- 261
            .                                                       .|||::
Frog   409 FLEDILRSTGYRNKGMLKYNKEKQCEEKQKTTLTEWYSAKQKNMKPETQRQRSVPAIKEEYDILD 473

  Fly   262 --------------------------------------------------------DYIHT---- 266
                                                                    ||.|:
Frog   474 DGGDTAFGQMTEKDANCLEPWLIKEIDACLSDIWLYRDKDAFAQLFHLISTENVSVDYRHSETSA 538

  Fly   267 ----------------------------------------------------------------- 266

Frog   539 TPLMVAAGQGFLSHVEQLISMGANIQSKASNGWMALDWAKHFGQTEVVDLLESYSASLETEDLDE 603

  Fly   267 -----------------------------------VLVTLFHIHRTTPKNHDVLIFLTGQEEIES 296
                                               ::..||:|.:.|... .:||||.|.:||..
Frog   604 NTLVQSDGNDLSIEDRELLKAYHHSFDDEKVDLDLIMHVLFNICQITDTG-AILIFLPGYDEIVG 667

  Fly   297 LAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRC 361
            |..:|....|..........||.|::.:....|.:.....||.:||:||:|||||||||:..:..
Frog   668 LRDRILLDDKRFADNAQRYHVFMLHSNMQTSDQKKVLKLPPAGIRKIILSTNIAETSITVNDVVF 732

  Fly   362 VIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPE 426
            |||.|.||||||:.::.:.:||.|.||||.|.||.|||||...|.|:|.::|....:..:...||
Frog   733 VIDSGKVKEKSFDALNNVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSKLRFQNMLEFQTPE 797

  Fly   427 ILRTNPTSMVLQL-LALDIDCNNFDFL----DPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGR 486
            :||.....:.|.. |.:.|:|...|||    :||....:|:|.:.|..:.|:...:|  :|.:|.
Frog   798 LLRIPLHELCLHTKLLVPINCPVADFLMKAPEPPPALIVRNAVQMLKTIDAMDNWED--LTEIGH 860

  Fly   487 QMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFV--SNSEKNEMAALAHAKFQS-KHG 548
            .:...|::|...|::|.|....|::.||::...|:....||  |.:.:...|.|...:|.: ...
Frog   861 HLADLPVEPHLGKMVLCAVILKCLDPILTIACTLAYRDPFVLPSQASQKRAAMLCRKRFTAGTFS 925

  Fly   549 DHLTLLNVFNGFLKSEK---PKMWCHDNYLNLRSLTYARNVRRQL------------------RE 592
            ||:.||..|..:.|::.   .:.:|..|:|:..::.....:|.||                  |:
Frog   926 DHMALLRAFQAWQKAKSDGWERAFCEKNFLSQATMEIIIGLRTQLLGQLRASGFVRARGGGDIRD 990

  Fly   593 ISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVL-HGKYK--P 654
            ::      :| |::..::|..:|:|.:.|:..:.|:...::.....|.:.||||.| ..:||  |
Frog   991 VN------IN-SENWAVVKAALLSGMYPNLIHVDRENMVLSGVKEKRVRFHPSSALSEPQYKKIP 1048

  Fly   655 SYILFTEIVQTEQTFLRQVTEISIEWI 681
            |.....|.||...|          :|:
Frog  1049 SANCQAEAVQALPT----------DWL 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
ythdc2	XP_004910524.1	R3H_DEXH_helicase	76..134	CDD:100077
		HrpA	219..>1046	CDD:224557	216/841 (26%)
		ANK repeat	535..567	CDD:293786	0/31 (0%)
		ANK repeat	569..600	CDD:293786	0/30 (0%)
		OB_NTP_bind	1001..1096	CDD:369483	20/75 (27%)
		YTH	1316..1447	CDD:367840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910