DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and Dhx35

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001359442.1	Gene:	Dhx35 / 71715	MGIID:	1918965	Length:	703	Species:	Mus musculus

Alignment Length:	648	Identity:	274/648 - (42%)
Similarity:	403/648 - (62%)	Gaps:	32/648 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNG-MIGITQPRR 123
            |||||::.||||..|:.||..:|...||:|:.|||.||:|||||:|..||:...| ::|:|||||
Mouse    46 SIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRR 110

  Fly   124 VAAITVARRVAQELNGTIGDTVGYTVRFEDVTS-RATKIRFLTDGVLLRESIKDRLLLKYSVIIL 187
            |||:|||.|||.|....:|..|||.:||:|.|. .||:|:|||||:|:||.:.|.||.|||||:|
Mouse   111 VAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIML 175

  Fly   188 DEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-----------CKG 241
            |||||||:..|:..|::|..||:|     .:|:::|.|||:|.:.|.::||           ...
Mouse   176 DEAHERTLYTDIAIGLLKKIQKKR-----GDLRLIVASATLDAEKFRDFFNQNETSDPARDTSVT 235

  Fly   242 MYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIES----LAQQIR 302
            :.:||||:||.:.:.:....|||...:.|:..||: |..:.|:|.|||||||:|:    |.:|.|
Mouse   236 LTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQ-TEGDGDILAFLTGQEEVETVVSMLIEQAR 299

  Fly   303 QLAKIDTTG-TTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCG 366
            .||:   || ...|||..:||.|...:|::.|.....:|||||:|||:|||||||.||..|||||
Mouse   300 ALAR---TGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCG 361

  Fly   367 FVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTN 431
            |:|.:::|....::.|..|.:|:|.|.|||||.||:..|.|||.||:...|....:|.||:.|:|
Mouse   362 FMKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSN 426

  Fly   432 PTSMVLQLLALDID-CNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYIT-PLGRQMVQYPLD 494
            ...::|||.||.|| ...|.|:.||....:..|.:.|.|||.:  ..|..:| |||.::.::||:
Mouse   427 LAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGL--DKDCRLTEPLGMRIAEFPLN 489

  Fly   495 PKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNG 559
            |.::|:||.:.:|||.:|:||:.:::...:|||..|.:...|...|.||..:.|||||:|||:..
Mouse   490 PMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEA 554

  Fly   560 FLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEHLHL-ALNSSDDIEMLKKCILNGFFENIA 623
            |:|..|...||.:::||.:.|..|..||.||:::.....: .::|..|.:.:.:||::|||.|.|
Mouse   555 FIKHNKSSQWCQEHFLNYKGLVRAATVRDQLKKLLVKFQVPKVSSEGDPDPVLRCIVSGFFANAA 619

  Fly   624 VLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            .....|.|.|...:....|||:|||:.:..|.::::.|::||.:.::|.||.|...|:.|:.|
Mouse   620 RFHSSGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx35	NP_001359442.1	HrpA	21..682	CDD:224557	273/646 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720