DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and YTHDC2

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_011541883.1	Gene:	YTHDC2 / 64848	HGNCID:	24721	Length:	1439	Species:	Homo sapiens

Alignment Length:	869	Identity:	222/869 - (25%)
Similarity:	347/869 - (39%)	Gaps:	279/869 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 QIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLA 108
            ::...|..|.:....:..:..::|||||..:..|:|.::.|..|||:.|||||||||||||||..
Human   169 RLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDD 233

  Fly   109 GYAKNGM---IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLL 170
            .: |||:   |..|||||:|||.||.|||.|....||.|:||.:|.|...|..|.:.|.|:||||
Human   234 CF-KNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLL 297

  Fly   171 RESIK-DRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFG 234
            |..:. |..|...:.:|:||.|||...:|.|...::|.     .||...||::::||.:|::.|.
Human   298 RTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDL-----LQKHPTLKLILSSAALDVNLFI 357

  Fly   235 NYF-NCKGMYLEGRTYPVR---------------------------------------------- 252
            .|| :|..:|::||.:.|:
Human   358 RYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSF 422

  Fly   253 ---------VMHTKEEHE----------------------------------------------- 261
                     |::..:|::
Human   423 KPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQ 487

  Fly   262 ------------DYIH------------------------------------------------- 265
                        ||.|
Human   488 VFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQ 552

  Fly   266 TVLVTLFHIHRTTPK----------------------------NHD------------------- 283
            |.:|.|...:..|.:                            :|.
Human   553 TEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNIC 617

  Fly   284 -------VLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVR 341
                   |||||.|.:||..|..:|....|.....|...:||.|::.:....|.:.....||.||
Human   618 HSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVR 682

  Fly   342 KVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGT 406
            |:||:|||||||||:..:..|||.|.||||||:.::.:.:||.|.||||.|.||.|||||...|.
Human   683 KIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGI 747

  Fly   407 CYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLAL------DIDCNNFDFL----DPPLEDGLR 461
            |:|.:::....:..:...||:||     |.||.|.|      .::|...|||    :||....:|
Human   748 CFRLFSRLRFQNMLEFQTPELLR-----MPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVR 807

  Fly   462 SAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVF 526
            :|.:.|..:.|:.|.:|  :|.||..:...|::|...|::|.|....|::.||::...|:....|
Human   808 NAVQMLKTIDAMDTWED--LTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPF 870

  Fly   527 V--SNSEKNEMAALAHAKFQS-KHGDHLTLLNVFNGFLKSEK---PKMWCHDNYLNLRSLTYARN 585
            |  :.:.:...|.|...:|.: ...||:.||..|..:.|:..   .:.:|..|:|:..::.....
Human   871 VLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIG 935

  Fly   586 VRRQL------------------REISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYI 632
            :|.||                  |:::       .:|::..::|..::.|.:.|:..:.|:...:
Human   936 MRTQLLGQLRASGFVRARGGGDIRDVN-------TNSENWAVVKAALVAGMYPNLVHVDRENLVL 993

  Fly   633 TASGNIRSKIHPSSVLHGKYKPSY 656
            |.....:.:.||:|||.   :|.|
Human   994 TGPKEKKVRFHPASVLS---QPQY 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077
		HrpA	189..>1016	CDD:224557	220/849 (26%)
		DEXHc_YTHDC2	193..368	CDD:350745	81/180 (45%)
		ANK repeat	505..537	CDD:293786	0/31 (0%)
		ANK repeat	539..564	CDD:293786	3/24 (13%)
		OB_NTP_bind	971..1066	CDD:369483	12/47 (26%)
		YTH	1288..1404	CDD:367840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810