Protein Alignment CG4901 and DHX35

DIOPT Version :9

• Sequence 1: NP_001334733.1
• Gene: CG4901 / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_068750.2
• Gene: DHX35 / 60625
• HGNCID: 15861
• Length: 703
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 277/648 - (42%)
• Similarity: 406/648 - (62%)
• Gaps: 32/648 - (4%)

  Fly    60 SIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNG-MIGITQPRR 123
            |||||::.||||..|:.||..:|...||:|:.|||.||:|||||:|..||:...| ::|:|||||
Human    46 SIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRR 110

  Fly   124 VAAITVARRVAQELNGTIGDTVGYTVRFEDVTSR-ATKIRFLTDGVLLRESIKDRLLLKYSVIIL 187
            |||:|||.|||:|....:|..|||.:||:|.|.: ||:|:|||||:|:||.:.|.||.|||||:|
Human   111 VAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLTKYSVIML 175

  Fly   188 DEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-----------CKG 241
            |||||||:..|:..|::|..||:|     .:|:::|.|||:|.|.|.::||           |..
Human   176 DEAHERTLYTDIAIGLLKKIQKKR-----GDLRLIVASATLDADKFRDFFNQNETSDPARDTCVI 235

  Fly   242 MYLEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIES----LAQQIR 302
            :.:||||:||.:.:.:....|||.:.:.|:..||: |..:.|||.|||||||:|:    |.:|.|
Human   236 LTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQ-TEGDGDVLAFLTGQEEVETVVSMLIEQAR 299

  Fly   303 QLAKIDTTG-TTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCG 366
            .||:   || ...|||..:||.|...:|::.|.....:|||||:|||:|||||||.||..|||||
Human   300 ALAR---TGMKRHLRVLPMYAGLPSFEQMKVFERVSRSVRKVIVATNVAETSITISGIVYVIDCG 361

  Fly   367 FVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTN 431
            |||.:::|....::.|..|.:|:|.|.|||||.||...|.|||.||:...|....:|.||:.|:|
Human   362 FVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAFDKLPQSTVPEMQRSN 426

  Fly   432 PTSMVLQLLALDID-CNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYIT-PLGRQMVQYPLD 494
            ...::|||.||.|| ...|.|:.||....:..|.:.|.|||.:  ..|..:| |||.::.::||:
Human   427 LAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGL--DKDCRLTEPLGMRIAEFPLN 489

  Fly   495 PKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNG 559
            |.::|:||.:.:|||.:||||:.:::...::||....:...|...|.||..:.|||||:||::..
Human   490 PMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTMLNIYEA 554

  Fly   560 FLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSD-DIEMLKKCILNGFFENIA 623
            |:|..|...||.:::||.:.|..|..||.||:::.....:...||: |.:::.:||::|||.|.|
Human   555 FIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSEGDPDLVLRCIVSGFFANAA 619

  Fly   624 VLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            .....|.|.|...:....|||:|||:.:..|.::::.|::||.:.::|.||.|...|:.|:.|
Human   620 RFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESAWLLELAP 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
DHX35	NP_068750.2	DEXDc	53..224	CDD:214692	92/175 (53%)
		DEXDc	73..211	CDD:238005	77/142 (54%)
		DEAH box	176..179		2/2 (100%)
		HELICc	301..396	CDD:197757	48/97 (49%)
		HA2	465..549	CDD:214852	32/85 (38%)
		OB_NTP_bind	584..683	CDD:285018	32/99 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730