DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and dhx30

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_021322211.1	Gene:	dhx30 / 570735	ZFINID:	ZDB-GENE-130530-833	Length:	1173	Species:	Danio rerio

Alignment Length:	735	Identity:	215/735 - (29%)
Similarity:	351/735 - (47%)	Gaps:	116/735 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSE 92
            ||:.:.|....:|..|   :.::..||:..:.....:...|||...:..||:.:.::..|:|..|
Zfish   357 DAITSKPYRALEPKEA---EHLSQRLLSMWKRVGPARGAELPVDAHKESILEAVRSSQVVVISGE 418

  Fly    93 TGSGKTTQIPQFLL----LAGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFED 153
            ||.||||:||:|||    |.|......:.:|||||::|::||:|||.|:...:...|||.||.|
Zfish   419 TGCGKTTRIPRFLLEDGVLRGEGAECNVLVTQPRRISAVSVAQRVAHEIGPALQHCVGYQVRLE- 482

  Fly   154 VTSRATK-----IRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRK 213
              ||..:     :.|||.||||::...:..|...|.:|:||.|||.|..|||..:::.....|
Zfish   483 --SRPPERSGGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDVQTDLLLHLLRCVLSLR-- 543

  Fly   214 QKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVMHT--------------------- 256
               ..|||::.||:.|......|| .|..:.:.|..:|||....
Zfish   544 ---PELKVLLMSASGDSQRLAQYFGGCPVLRVPGFMHPVRARFLEDMQLDSRRPLLDMGSTQWSA 605

  Fly   257 -------KEEHE-----DYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDT 309
                   |||:.     |.:..|   :.|||||.... .||.||.|.:||:::.||:.:.....:
Zfish   606 EVRGRMGKEENNVTPDLDLVADV---IDHIHRTGEPG-AVLCFLPGWQEIKAVQQQLEEKQAYRS 666

  Fly   310 TGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFN 374
            ....   :..|::.::..:|...|...||..||::||||||||||||..|..|:|.|..||::::
Zfish   667 GSQI---ILPLHSSMAVSEQQVVFQRPPAGQRKIVLATNIAETSITIDDIVHVVDAGVQKEQNYD 728

  Fly   375 TVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQL 439
            ....:..|.:|.||:|...||.|||||...|..|..:.:.:::.......||||||...|:|:|
Zfish   729 PRTKVSALNTVWISQANVTQRRGRAGRCQPGHSYHLFPRKQLERMEPFPVPEILRTPLESVVMQ- 792

  Fly   440 LALDIDCNNF---DF----LDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKY 497
              ..|.|...   ||    ||.|....:|:|.|:|..:|.:...:|  :||||..:.....||:.
Zfish   793 --AKIHCPESKAEDFLSQVLDSPDTQAVRTAVKNLMDIGVLDASED--LTPLGHHVSCMSCDPRL 853

  Fly   498 SKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHG-DHLTLLNVFNGFL 561
            .|:|:.::.|.|::.:||:|:.|:.| .|.::.:...:.:.|.|:.....| |:|    ||:..:
Zfish   854 GKVLVFSALFSCVQPVLSVVACLTRD-PFYNSLQNRTLVSKAKAELSGSSGSDYL----VFSRVV 913

  Fly   562 KS--EKPKMWCHDNYLNLRSLTYA--RNVRRQLREISEHL-------H----LALNS-----SDD 606
            :|  |:.......:||:..:|:.|  |.:...:::.|::|       |    |.|:|     |.:
Zfish   914 QSWREQHSRDSRQDYLDKHTLSGASLRFIHGLMQQFSDNLCEAGLVDHSAECLRLSSPVNQQSKE 978

  Fly   607 IEMLKKCILNGFFENIAVLQRDGFYITASGNIRSK------------IHPSSVLHGK---YKPSY 656
            .:::...:|.|.:.|:..:::.  .:|.||..|::            :|.|||...|   :....
Zfish   979 EQLITAVLLAGLYPNLIQVKKG--VVTKSGRFRAENVSFRTESGPVLLHRSSVNRDKQHLWSRWL 1041

  Fly   657 ILFTEIVQTEQTFLRQVTEI 676
            ..|:.:..:.|.|:|..|.:
Zfish  1042 TFFSAVKSSGQVFIRDSTVV 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
dhx30	XP_021322211.1	HrpA	371..>929	CDD:224557	182/585 (31%)
dhx30	XP_021322211.1	OB_NTP_bind	947..1069	CDD:311586	24/117 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810