Protein Alignment ath and ythdc2

DIOPT Version :10

• Sequence 1: NP_609356.2
• Gene: ath / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_021332046.1
• Gene: ythdc2 / 567114
• ZFINID: ZDB-GENE-220119-1
• Length: 1381
• Species: Danio rerio
• Alignment Length: 853
• Identity: 212/853 - (24%)
• Similarity: 341/853 - (39%)
• Gaps: 276/853 - (32%)

  Fly    56 SKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLL--LAGYAKNGMIGI 118
            |....::..:|:|||:..:.:|::.:..:..||::.|||||||||||||||  .:..|....|..
Zfish   171 SSAPELDAFRKALPVYELQEQIIQSIRDHQVVLVLGETGSGKTTQIPQFLLDDCSATASPCRIFC 235

  Fly   119 TQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIK-DRLLLKY 182
            |||||:|.|.||.|||.|....||.||||.:|.|...|..|.:.|.|.|||||..:. |..|...
Zfish   236 TQPRRLATIAVAERVAAERGENIGQTVGYQIRLESRVSPKTLLTFCTSGVLLRTLMAGDEALSTV 300

  Fly   183 SVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEG 246
            :.:|:||.|||....|.|...:|:.     .||:.||::|::||.:|:..|..|| :|..::::|
Zfish   301 THVIVDEVHERDGLTDFLLTKMKEV-----LQKMPNLRLVLSSAALDVSLFMRYFGSCPVIHIKG 360

  Fly   247 RTYPVR----------------------------------------------------------- 252
            ..|.|:
Zfish   361 CPYEVKQLFLEDILRSTAYTNKDMIKYKKEAQKEESQQCSLSEWCERDVPQADPPERPTVCVLQD 425

  Fly   253 ----------------------------------------------------------------- 252
                                                                             
Zfish   426 NQLLDDGGDSVFSQMSEKDVSSLEPWLLREMDSCISSIFLNQDADAFTQLFNLILNENISVDYRH 490

  Fly   253 ----------------VMHTK-----------------------------------EEH------ 260
                            |.||:                                   |.|
Zfish   491 SETSATALMVSAGRGFVSHTEQLLNMGANINIKASNGWTALDWAKHFKQTEAVDLLESHIWCAEA 555

  Fly   261 ------------------ED------YIHTV------LVTLFHIHRTTPKNHD---VLIFLTGQE 292
                              ||      |.|:.      |..:.|:..:..::.|   |||||.|.:
Zfish   556 SPQDEASLLQNSSCELSCEDQELLKAYHHSFDDEKVDLQLILHLLHSICQSSDQGAVLIFLPGYD 620

  Fly   293 EIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIP 357
            ||.||..||....|..|......:||.|::.:....|.:....||..|||:||:|||||||||:.
Zfish   621 EIVSLRDQILFDDKRFTEHQQRFQVFVLHSSMQTSDQKKVLKSTPKGVRKIILSTNIAETSITVS 685

  Fly   358 GIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADA 422
            .:..|||.|.||||:::.::.:.:||.|.||||.|.||.|||||...|.|:..:::....:..:.
Zfish   686 DVVFVIDSGKVKEKAYDALNNVTMLKMVWISKASALQRKGRAGRCRPGVCFHLFSRLRFSNMLEH 750

  Fly   423 TQPEILRTNPTSMVLQLLAL------DIDCNNFDFL----DPPLEDGLRSAYKSLDALGAIKTGD 477
            ..|::||     |.||.|.|      .|:|...:||    :||..:.::.|.:.|..:.|:...:
Zfish   751 QIPQLLR-----MPLQELCLHTKLLAPINCPVAEFLSRAPEPPHINTVKHAVQMLKTIDAMDPWE 810

  Fly   478 DSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFV--SNSEKNEMAALAH 540
            :  :|.||..:...|::|...|::|.|....|::.:|::...|:....||  :.:.:..:|.|..
Zfish   811 N--LTELGLHLADLPVEPHLGKMVLCAVVLKCLDPVLTIACTLAHREPFVLPAQAAQRRVAMLCR 873

  Fly   541 AKFQSK-HGDHLTLLNVFNGFLKSEK---PKMWCHDNYLNLRSLTYARNVRRQL----------- 590
            .:|.:. ..||:.||..|..:.|:..   .:.:|..|:|:..::....::|.||
Zfish   874 RRFTANTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIVSMRTQLLGQLRATGFVR 938

  Fly   591 -------REISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVL 648
                   |::::       :|::..::|..::.|.:.|:  :.|||..::.....:.::||:|||
Zfish   939 ARGGGDIRDVNQ-------NSENWAVVKAALVAGMYPNL--IHRDGLSLSGEKEKKVRLHPTSVL 994

  Fly   649 HGKYKPSY 656
            .   :|.|
Zfish   995 S---QPQY 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ath	NP_609356.2	HrpA	67..>686	CDD:441249	210/842 (25%)
ythdc2	XP_021332046.1	R3H_DEXH_helicase	36..94	CDD:100077
		PRK11131	169..>1003	CDD:182986	212/853 (25%)
		DEXHc_YTHDC2	183..358	CDD:350745	76/179 (42%)
		ANKYR	<473..>549	CDD:440430	4/75 (5%)
		ANK repeat	496..524	CDD:293786	3/27 (11%)
		SF2_C_RHA	584..739	CDD:350178	63/154 (41%)
		OB_NTP_bind	958..1050	CDD:400182	13/47 (28%)
		YTH	1249..1378	CDD:410979