DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and DHX32

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_060650.2	Gene:	DHX32 / 55760	HGNCID:	16717	Length:	743	Species:	Homo sapiens

Alignment Length:	678	Identity:	196/678 - (28%)
Similarity:	341/678 - (50%)	Gaps:	64/678 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 TSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQ----FLLLAGYAKNGM 115
            :|:...:.::::.||::..::..::.|..|..|::..:...||:.|:||    :.|...|...|:
Human    49 SSRYYKLLKEREDLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHGGV 113

  Fly   116 IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLL 180
            | .||..:...:.:|.|||.|::..||..|||.:.||:..:..|.:|:.||.:|.||.:.:..|.
Human   114 I-CTQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMSNPFLG 177

  Fly   181 KYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMYLE 245
            .|.|||||:.|||::..|:|.|::||....|     ..||:::.|:...|....:|:....:...
Human   178 SYGVIILDDIHERSIATDVLLGLLKDVLLAR-----PELKLIINSSPHLISKLNSYYGNVPVIEV 237

  Fly   246 GRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTT 310
            ...:||.|::..|..:|...::|..:|.||.:..|. |:::||..:::||.:.:.:.|.:.:: .
Human   238 KNKHPVEVVYLSEAQKDSFESILRLIFEIHHSGEKG-DIVVFLACEQDIEKVCETVYQGSNLN-P 300

  Fly   311 GTTDLRVFTLYAQLSQGKQLECFVPTPAN-------VRKVILATNIAETSITIPGIRCVIDCGFV 368
            ...:|.|..||.:    ::...|.|....       .|:|:|.|:..|..|....:|.|||.|..
Human   301 DLGELVVVPLYPK----EKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGVE 361

  Fly   369 KEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFA--DAT--QP-EIL 428
            :.|.:|.....:.|....||::||..|....|..:.|..:..||    :.||  |.|  :| |:.
Human   362 RRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYT----EEFASKDMTPLKPAEMQ 422

  Fly   429 RTNPTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYP 492
            ..|.|||||.:..:|| ...:.||::.|..:.|..|.:.||.|.|:  .:|..::..|..|.::|
Human   423 EANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAAL--DNDGNLSEFGIIMSEFP 485

  Fly   493 LDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAK-FQSKHGDHLTLLNV 556
            |||:.||.:|.:..|.|::|:|::.:::::.:.|.......|.|||...| |....|||.||:::
Human   486 LDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHPEGDHFTLISI 550

  Fly   557 FNGF----LKSEKP---KMWCHDNYLNLRSLTYARNVRRQLREISEHLHL-----ALNSSDDIEM 609
            :..:    |.|...   :.||.|.:||..:|..|..:|.:|.||.:.:.|     |..|.::...
Human   551 YKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENTLN 615

  Fly   610 LKKCILNGFFENIAVLQRD----GFYITASGNIRSKIHPSSVLHG----KYKPSYILFTEIVQTE 666
            :||.:|:|:|..||   ||    |.|:..:....:::||   |.|    |..|.::||.:...:|
Human   616 IKKALLSGYFMQIA---RDVDGSGNYLMLTHKQVAQLHP---LSGYSITKKMPEWVLFHKFSISE 674

  Fly   667 QTFLRQVTEISIEWIKEVVP--FVKNIP 692
            ..::|..:|||.|...::||  :..|:|
Human   675 NNYIRITSEISPELFMQLVPQYYFSNLP 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
DHX32	NP_060650.2	Preny group binding site; CAAX box	1..743		196/678 (29%)
		HrpA	12..679	CDD:224557	187/653 (29%)
		DEAD/DEXH domain	146..403		73/267 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820