DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and dhx29

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_697933.6	Gene:	dhx29 / 553505	ZFINID:	ZDB-GENE-130530-606	Length:	1377	Species:	Danio rerio

Alignment Length:	776	Identity:	232/776 - (29%)
Similarity:	366/776 - (47%)	Gaps:	156/776 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTT 99
            ::|:......:|...:|:   ::|  :..::|.||||..|.::|:.|..:..::|..||||||:|
Zfish   546 VVEEASRRLLLKLQASPL---ARR--LLDERKQLPVFQHREQVLEALRHHRVLVIAGETGSGKST 605

  Fly   100 QIPQF----LLLAG-YAKNGMIGITQPRRVAAITVARRVAQELN-----GTIGDTVGYTVRFEDV 154
            |||||    ||.|| .|:...:.:|||||::|:::|.||:|||.     |::....||.:|.|:.
Zfish   606 QIPQFILEELLAAGDTAQPCSVVVTQPRRISAMSLACRVSQELGSEDGPGSMNSLCGYQIRMENR 670

  Fly   155 TSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANL 219
            :|.||::.:.|.|||||:..:||.|...:.||:||.|||:|.:|.|..|:|:...:|     |:|
Zfish   671 SSEATRLLYCTTGVLLRKLQQDRHLNSLTHIIVDEVHERSVQSDFLLTILKEVVHKR-----ADL 730

  Fly   220 KVVVTSATMDIDHFGNYFN-CKGMYLEGRTYPVRVMH----------------------TKEEHE 261
            ::::.|||:|...|.|||| |..:.:.|||:||.|.|                      .:||.|
Zfish   731 RLILMSATVDCQKFANYFNRCPVVSIPGRTFPVEVFHLEDIVEETGYVLEQDSEYSQKFVEEEEE 795

  Fly   262 DYI-----------HTVLVT------------LFHIHRTT--------PK--NHD---------- 283
            ..|           |..|:.            |.|....|        |.  |.|
Zfish   796 VNIGITQKGGKTVQHQELIVRDSASGWDLGPELDHFSSRTRHILQYMNPNKINMDLILDLLAYLD 860

  Fly   284 -----------VLIFLTGQEEIESLAQQIRQLAKIDT--TGTTDLRVFTLYAQLSQGKQLECFVP 335
                       ||:||.|...|    ||:..|...|.  :.....::..|::.||...|...|..
Zfish   861 KSPQFNAVDGAVLVFLPGLAHI----QQLHDLLSTDKRFSSKDRYKLVALHSSLSSQDQSSAFTV 921

  Fly   336 TPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAG 400
            .||.|||::|:||||||.:|||.:..|||.|..||..::....:..|..:.:|||.|.||.||||
Zfish   922 PPAGVRKIVLSTNIAETGVTIPDVVFVIDTGRTKENRYHESSQMSSLVEMFVSKASALQRQGRAG 986

  Fly   401 RDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDIDCNNFDF----LDPPLEDGLR 461
            |..:|.|:|.|.|...:||.|.:.|||||.....:.|.::..:..... ||    ||.|.:..:.
Zfish   987 RVREGFCFRLYPKFRFESFIDYSIPEILRVPLEELCLHIMKCEYGSPE-DFLSRSLDAPQQQAVC 1050

  Fly   462 SAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVF 526
            :|...|..:||.:. |...:||||..:...|::.|..|:|:..:.|||:|.|.::.:.:|....|
Zfish  1051 NAVSLLRRIGACQQ-DTHTLTPLGHHLAALPVNVKIGKMLIFGAIFGCLEPIATIAAAMSEKSPF 1114

  Fly   527 VSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSE----KPKM-WCHDNYLNLRSLTYARNV 586
            .:...:.|.|.||.:.....:.||:|:...:.|:..|.    :.:| :|..::||..:|.....|
Zfish  1115 ATPMSRKEEANLAKSALAVANSDHMTIYKAYLGWRSSRTEGTRAEMNYCRRHFLNRTALITIEEV 1179

  Fly   587 RRQLREISEHLHLALN--------------------SSDDIEMLKKCILNGFFENIA-VLQRDGF 630
            :::|..:.|......:                    |:.|:.::|..:..|.::|:. :|.....
Zfish  1180 KQELMRMVEQAGFVSSKLGRTPRPRPSTETKAPLSISTQDVCVVKATLTAGLYDNVGRILYSPSL 1244

  Fly   631 YI---------TASGNIRSKIHPSSV-----LHGKYKPSYILFTEIVQTEQTFLRQVTEIS 677
            .:         ||.|  ::.:|||||     .||     ::||.|.|:..:.||:..|.||
Zfish  1245 DVQERVVCVVETAQG--KAHVHPSSVNRFLQTHG-----WMLFQEKVKYSKVFLKDTTLIS 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
dhx29	XP_697933.6	DEXDc	568..766	CDD:214692	85/202 (42%)
		DEXDc	591..738	CDD:238005	63/151 (42%)
		HELICc	841..996	CDD:238034	53/158 (34%)
		HA2	1065..1140	CDD:214852	22/74 (30%)
		OB_NTP_bind	1181..1309	CDD:285018	27/125 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810