DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4901 and tdrd9

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001123984.1	Gene:	tdrd9 / 553222	ZFINID:	ZDB-GENE-090313-193	Length:	1342	Species:	Danio rerio

Alignment Length:	716	Identity:	201/716 - (28%)
Similarity:	330/716 - (46%)	Gaps:	130/716 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 TSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGM---I 116
            ||..:....:...||:...|..::..:|.|..|:|...||||||||:||| :|..||:..:   :
Zfish    76 TSPPSLASYEYPILPITKNRQELVSLIENNSVVIIRGATGSGKTTQLPQF-ILDHYAERNIPCNL 139

  Fly   117 GITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLK 181
            .:||||::.|..:||.||:|...|:|..|||.|..|.:.:..||:.::|.||||::.:..:.|.:
Zfish   140 VVTQPRKIGATGIARWVARERKCTLGSLVGYQVGLEKMATEHTKLIYVTTGVLLQKLVSSKTLTE 204

  Fly   182 YSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF--------N 238
            ||.|.:||.|||:...|.|..:|:...:...:.    :||::.|||::...|..||        |
Zfish   205 YSHIFIDEVHERSEELDFLLLVVRKLLRSNSRY----VKVILMSATINCIEFAEYFGSPIRNQMN 265

  Fly   239 CKGMY-LEGRTYPVRVMHTKE---------------EHEDYI----HTVLVTLFHI--------H 275
            ...:: :||..|.|...:..|               ..:.||    :.|.|:|...        |
Zfish   266 PAYVFEVEGAPYAVEEYYLDELKTMLPVGVNLDLTLPQDPYITEEMYNVAVSLIQSFDEMEAKDH 330

  Fly   276 R--------TTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLEC 332
            |        |.|:...||:||.|..||:.:.:.:.:|.:      ..|:|:.|::.::..:|...
Zfish   331 RRSEQTGSTTHPERGSVLVFLPGLAEIQYMKEALSKLVR------KRLQVYPLHSTVTLEEQNGV 389

  Fly   333 F-VPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRA 396
            | ||.| ..||:||:|||||:|:|:|.::.|||...|::.:.:.......|:....||....||.
Zfish   390 FLVPVP-GYRKIILSTNIAESSVTVPDVKYVIDFCLVRQLACDKETNYRCLRITWASKTSCNQRR 453

  Fly   397 GRAGRDADGTCYRAYTK----AEMDSFADATQPEILRTNPTSMVLQLLALDI-DCNNF--DFLDP 454
            |||||.:.|.|||..|:    .|:.:|   :.||:||:...|.:|::..||: |..:.  ..|.|
Zfish   454 GRAGRVSKGFCYRLVTRHFWENEIPNF---SIPEMLRSPLASTLLKVKLLDMGDPRSVLSTALTP 515

  Fly   455 PLEDGLRSAYKSLDALGAIKTGDDSY------ITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEI 513
            |:...:......|..:||:....:|.      :|.|||.:.|.|:|.:..||::....|||:||.
Zfish   516 PILGDIERTVLQLKQIGALSVQSNSQRQFDGDLTFLGRVLAQLPVDLQLGKLIVLGHVFGCLEEC 580

  Fly   514 LSLVSVLSSDHVFVSNSEKNEMAALAHAKF-QSKHGDHLTLLNVF--------NGFLKSEKPKM- 568
            |.:.:.||....|...|.:......:...| |:...|.:..:|.|        .|.|:..|.::
Zfish   581 LIIAASLSLKSFFAMPSLQQLAGYRSKLSFAQNVPSDFIAYVNAFKAWYTSRAKGELRHPKDELE 645

  Fly   569 WCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYIT 633
            |..:|.:.:          :::||::|.          .|.|||.:           .|...:|:
Zfish   646 WGKENCIQI----------KRIREVAEL----------FEDLKKRV-----------SRFNMHIS 679

  Fly   634 ASGNIR--SKIHPSS-----VLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVPFVKNI 691
            :|.|..  :.:|...     |:.|...|:|....||  .||...:   |:|....|..: .::|:
Zfish   680 SSSNPTDYTSLHKQRFILQVVIAGALFPNYFSQGEI--DEQLASK---ELSGNDPKTTI-LIRNL 738

  Fly   692 P 692
            |
Zfish   739 P 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
tdrd9	NP_001123984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..81		2/4 (50%)
		DEXDc	84..262	CDD:214692	65/182 (36%)
		DEXDc	106..247	CDD:238005	56/145 (39%)
		DEAH box. /evidence=ECO:0000250\|UniProtKB:Q14BI7	211..214		2/2 (100%)
		Helicase_C	343..459	CDD:278689	41/122 (34%)
		HA2	530..622	CDD:214852	25/91 (27%)
		TUDOR	851..972	CDD:278965
		TUDOR	905..954	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910