DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and DHX29

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_061903.2	Gene:	DHX29 / 54505	HGNCID:	15815	Length:	1369	Species:	Homo sapiens

Alignment Length:	746	Identity:	217/746 - (29%)
Similarity:	356/746 - (47%)	Gaps:	136/746 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 TSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQF----LLLAGY-AKNG 114
            |.|...:.::::.||||..|..|::.|:.:..|::..||||||:||:|.|    |||..: |...
Human   559 TPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNEWEASKC 623

  Fly   115 MIGITQPRRVAAITVARRVAQEL---NGTIG--DTVGYTVRFEDVTSRATKIRFLTDGVLLRESI 174
            .|..|||||::|:::|.||..||   ||..|  ...||.:|.|.....:|::.:.|.|||||:..
Human   624 NIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCGYQIRMESRACESTRLLYCTTGVLLRKLQ 688

  Fly   175 KDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-N 238
            :|.||...|.:|:||.|||:|.:|.|..|:|:.     .||.::|.:::.|||:|.:.|..|| :
Human   689 EDGLLSNVSHVIVDEVHERSVQSDFLLIILKEI-----LQKRSDLHLILMSATVDSEKFSTYFTH 748

  Fly   239 CKGMYLEGRTYPVRVMHTKE--------------------------------------EHEDYI- 264
            |..:.:.||:|||.|.|.::                                      ::::||
Human   749 CPILRISGRSYPVEVFHLEDIIEETGFVLEKDSEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIP 813

  Fly   265 ---------------------HTVL------------VTLFHIHRTTPKNHD----VLIFLTGQE 292
                                 |.:|            :.|......:|:..:    |||||.|..
Human   814 VQTGAHADLNPFYQKYSSRTQHAILYMNPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLA 878

  Fly   293 EIESLAQQIRQLAKIDTTGTTD-LRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITI 356
            .|    ||:..|...|....:: .:|..|::.||...|...|...|..|||::||||||||.|||
Human   879 HI----QQLYDLLSNDRRFYSERYKVIALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITI 939

  Fly   357 PGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFAD 421
            |.:..|||.|..||..::....:..|....:|||.|.||.|||||..||.|:|.||:...:.|.|
Human   940 PDVVFVIDTGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMD 1004

  Fly   422 ATQPEILRTNPTSMVLQLLALDIDCNNFDF----LDPPLEDGLRSAYKSLDALGAIKTGDDSYIT 482
            .:.|||||.....:.|.::..::.... ||    ||||....:.:|...|..:||.:..:.. :|
Human  1005 YSVPEILRVPLEELCLHIMKCNLGSPE-DFLSKALDPPQLQVISNAMNLLRKIGACELNEPK-LT 1067

  Fly   483 PLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKH 547
            |||:.:...|::.|..|:|:..:.|||::.:.:|.:|::....|.:...:.:.|.||.:......
Human  1068 PLGQHLAALPVNVKIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMAD 1132

  Fly   548 GDHLTLLNVFNGFLKSEKPK------MWCHDNYLNLRSLTYARNVRRQLREISEHLHLALN---- 602
            .||||:.|.:.|:.|:.:..      .:|..|:||..||....:|:::|.::.:....:.:
Human  1133 SDHLTIYNAYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTST 1197

  Fly   603 -----------SSDDIEMLKKCILNGFFENIA---------VLQRDGFYI-TASGNIRSKIHPSS 646
                       |..:|.:||..::.|.::|:.         |.::....: ||.|  ::::||||
Human  1198 SWEGNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQG--KAQVHPSS 1260

  Fly   647 VLHGKYKPSYILFTEIVQTEQTFLRQVTEIS 677
            |........::|:.|.::..:.:||:.|.|:
Human  1261 VNRDLQTHGWLLYQEKIRYARVYLRETTLIT 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
DHX29	NP_061903.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..526
		DEXDc	578..764	CDD:214692	75/190 (39%)
		DEXDc	589..736	CDD:238005	60/151 (40%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	702..705		2/2 (100%)
		Helicase_C	847..985	CDD:278689	52/141 (37%)
		HA2	1056..1137	CDD:214852	21/81 (26%)
		OB_NTP_bind	1179..1302	CDD:285018	22/115 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810