DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4901 and dhx16

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	665	Identity:	277/665 - (41%)
Similarity:	416/665 - (62%)	Gaps:	34/665 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQI 101
            |.:|.::|.::         ::.||::.::|||:|..|..:|..:..:..::|..||||||||||
Zfish   390 ESEPELSQAEK---------QKQSIQEVRRSLPIFPYREDLLAAIGDHQILVIEGETGSGKTTQI 445

  Fly   102 PQFLLLAGYAKNGM-IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLT 165
            ||:||..||.|.|| ||.||||||||::||.|||||::..:|:.|||::||||.||..|.::::|
Zfish   446 PQYLLEEGYTKGGMKIGCTQPRRVAAMSVAARVAQEMSVKLGNEVGYSIRFEDCTSERTILKYMT 510

  Fly   166 DGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDI 230
            ||:||||.:.:..|..|||||:|||||||::.|:|||::||..:.|     .:|||:|.|||:|.
Zfish   511 DGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLIKDIARFR-----PDLKVLVASATLDT 570

  Fly   231 DHFGNYFNCKGMY-LEGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEI 294
            :.|.::|:...:: :.||.:||.:.:||....||:...:|::..|| .|....|||:||||||||
Zfish   571 ERFSSFFDDAPVFRIPGRRFPVDIYYTKAPEADYLEACVVSVLQIH-VTQSPGDVLVFLTGQEEI 634

  Fly   295 ESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGI 359
            |:..:.:::..:...:..::|.|..:||.|....|.:.|.|||...|||::||||||||:||.||
Zfish   635 EACCELLQERCRRLGSKISELLVLPIYANLPSDMQAKIFNPTPPGARKVVVATNIAETSLTIDGI 699

  Fly   360 RCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYT----KAEMDSFA 420
            ..|||.||.|:||:|...|::.|.....|:|.|.||||||||.|.|.|:|.||    |.||:
Zfish   700 IYVIDPGFCKQKSYNAKTGMESLIVTPCSRASANQRAGRAGRVAAGKCFRLYTAWAFKHEME--- 761

  Fly   421 DATQPEILRTNPTSMVLQLLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIK-TGDDSYITP 483
            :.|.|||.|||..::||.|.:|.| |..:|||:|||..:.|..|.:.|.||||:. .|:   :|.
Zfish   762 ETTVPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPPPHETLVLALEQLYALGALNHLGE---LTK 823

  Fly   484 LGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLS-SDHVFVSNSEKNEMAALAHAKFQSKH 547
            |||:|.:.|:||..||::|.:..:.|.||:|::.::|| ::.:|....:|...|..|...|....
Zfish   824 LGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNSIFYRPKDKVVHADNARMNFVVPG 888

  Fly   548 GDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSDDIEM-LK 611
            ||||.||||:..:::|.....||.:|::..||:..||:||.||..:.:.:.:.|.||:...| ::
Zfish   889 GDHLVLLNVYTQWVESGYSTQWCFENFIQFRSMKRARDVRDQLEGLMDRIEVELCSSNGDSMPIR 953

  Fly   612 KCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEI 676
            |.:..|:|.:.|.|.:.| |.|........:||:|.|. :.:|.::::.|:|.|.:.|:|||.||
Zfish   954 KAVTAGYFYHTARLSKGG-YKTVKHQQTVYVHPNSSLF-EEQPRWMIYHELVFTTKEFMRQVIEI 1016

  Fly   677 SIEWIKEVVP-FVKN 690
            ...|:.||.| :.||
Zfish  1017 ESGWLLEVAPHYYKN 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923
		GBP_C	<177..296	CDD:303769
		coiled coil	271..285	CDD:293879
		DEXDc	407..594	CDD:214692	95/191 (50%)
		DEXDc	429..568	CDD:238005	81/143 (57%)
		Helicase_C	612..742	CDD:278689	61/130 (47%)
		HA2	811..895	CDD:214852	31/86 (36%)
		OB_NTP_bind	916..1028	CDD:285018	38/113 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730