DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and CG8915

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	704	Identity:	198/704 - (28%)
Similarity:	333/704 - (47%)	Gaps:	86/704 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLL--L 107
            :.|.:.|...:::..:|:.:::|||::..|..||..|:.:..::|...|||||:||:||::|  .
  Fly   186 VGQRLIPPPQSNRNRNIQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWA 250

  Fly   108 AGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRE 172
            |.:.....|.::||||:|||:|:.|:::|.....|.||||.:|.....|..|.:...|.|.|||.
  Fly   251 AEHRAPVRIVVSQPRRIAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRA 315

  Fly   173 SIKDR--LLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGN 235
            ...|:  .....:.:|:||||||.::.|.|....|     ...||..:|::|:.|||||::...|
  Fly   316 LAMDKKSFFKNTTHLIIDEAHERDLDTDFLLLATK-----LELQKNPHLRLVLMSATMDLEALSN 375

  Fly   236 YFNCKG---MYLEGRTYPVRV------------MHTKEE-------------------------- 259
            ||.  |   |.:|||::.|.:            ||.:.|
  Fly   376 YFG--GGTVMDVEGRSFEVSIYHLEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIV 438

  Fly   260 HEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTT-GTTDLRVFTLYAQ 323
            |.|..:.::|:|..:.........|:::|.|..::.||      ||::::: ....:.:..|::|
  Fly   439 HPDIDNDLIVSLLELLLRQGDAGAVIVYLPGYSDMTSL------LARLESSLPREQITIILLHSQ 497

  Fly   324 LSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRIS 388
            :...:|.:.|...|....|:||:|||.:||||||.:..|||.|..|.|::::......|....||
  Fly   498 VDNSEQRKVFRTYPGVRLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWIS 562

  Fly   389 KAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILR--TNPTSMVLQLLALDIDCNNF-- 449
            :|.|.||||||||...|.|||.|....|......|.|||:|  .:...::.:|.|.|....||
  Fly   563 QADAKQRAGRAGRVCHGNCYRLYDNDRMARMNLYTIPEIMRRTLDEICLLTKLAAPDKKIENFLA 627

  Fly   450 DFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEIL 514
            ..||.|.:|.:..:...|..||.:...|:  :||||..:.:.||..:..|.|:.:....|::.::
  Fly   628 LALDTPPKDAVMQSCSRLKLLGVLDERDE--VTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMI 690

  Fly   515 SLVSVLSSDHVFVSNSEKNEMAA--LAHAKFQSK-HGDHLTLLNVFNGF--LKSEKPKMWCHDNY 574
            .:.:..|....||.|.|:.:.:.  ::...|... ..|.|.::.::..|  ||.:....:|..|:
  Fly   691 IIAAYHSVRDPFVLNIERGKKSGQQISRVLFAGDGMSDSLAVIKLYEEFTNLKRKDIGDFCERNF 755

  Fly   575 LNLRSL--------TYARNVRRQLREISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDG-F 630
            :...::        |....|.|..|.......||.:.::|..|::..:..|.:..:|.:.|:. .
  Fly   756 ICRNAMEMFVSAASTLRDTVYRIFRFSEASARLASSFNNDTNMIRLALTAGLYPKLAYMDRENKN 820

  Fly   631 YITASGNIRSKIHPSSVLHGKYK-----PSYILFTEIVQT--EQTFLRQVTEIS 677
            .:.|.|:...::..||.|.||.|     ..:|||.|..:|  :.:.|...|.:|
  Fly   821 QLVAEGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVS 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	69/187 (37%)
		DEXDc	226..368	CDD:238005	53/146 (36%)
		HELICc	479..575	CDD:197757	34/95 (36%)
		HA2	648..733	CDD:214852	20/86 (23%)
		OB_NTP_bind	783..884	CDD:285018	23/92 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840