Protein Alignment CG4901 and Dhx36

DIOPT Version :9

• Sequence 1: NP_001334733.1
• Gene: CG4901 / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_001101148.1
• Gene: Dhx36 / 310461
• RGDID: 1308767
• Length: 1000
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 200/760 - (26%)
• Similarity: 348/760 - (45%)
• Gaps: 145/760 - (19%)

  Fly    37 EKKPHVAQIKQTIAPILLTSKRTS---IEQQ--QKSLPVFNCRHRILKELEANDTVLIMSETGSG 96
            :.:|::...:|.:..  |..|:|.   ||.|  :|.||.:..:..::..:..:...:|..|||.|
  Rat   165 QNEPNLGLDQQLLED--LQKKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCG 227

  Fly    97 KTTQIPQFLLLAGYAKNGM-----IGITQPRRVAAITVARRVAQELNGTI--GDTVGYTVRFED- 153
            ||||:.|| :|..|.:.|:     |..|||||::||:||.|||.|...:.  |::.||.:|.:.
  Rat   228 KTTQVTQF-ILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSR 291

  Fly   154 VTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLAN 218
            :..:...|.:.|.|::|:....|..|...|.|:|||.|||.:.:|:|..::||....|     ::
  Rat   292 LPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFR-----SD 351

  Fly   219 LKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPV------------RVMHTKEEHEDYIHTVLVT 270
            |||::.|||::.:.|..|| ||..:::.|.|:||            |....::||........:.
  Rat   352 LKVILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQ 416

  Fly   271 LFHIHRTTPKNHD---------------------------------------------------- 283
             .|::|...:..:
  Rat   417 -GHVNRQEKEEKEAIYKERWPAYIKELQTRYSASTIDVLEMMDDDKVDLNLIAALIRYIVLEEED 480

  Fly   284 --VLIFLTGQEEIESLAQQI--RQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVI 344
              :|:||.|.:.|.:|...:  :.:.|.|.     ..:..|::.:....|.:.|..||..|||::
  Rat   481 GAILVFLPGWDNISTLHDLLMSQVMFKSDR-----FLIIPLHSLMPTVNQTQVFKKTPPGVRKIV 540

  Fly   345 LATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYR 409
            :|||||||||||..:..|||.|.:||..|:|.:.:..:.:..:|||.|.||.|||||...|.||.
  Rat   541 IATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 605

  Fly   410 AYTKAEMDSFADATQPEILRTNPTSMVLQLLALDIDCNNF---DFLDPPLEDGLRSAYKSLDALG 471
            .|.........|...||||||....:.||:..|.:....:   ..:|||.::.:..:.|.|..|.
  Rat   606 LYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELS 670

  Fly   472 AIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFV--------S 528
            |:...::  :||||..:.:.|::|...|::|..:.|.|::.:|::.:.||....||        :
  Rat   671 ALDKQEE--LTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIA 733

  Fly   529 NSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEK-----PKMWCHDNYLNLRSLTYARNVRR 588
            ::.:.|:|       :....||||::|.|.|:.::::     .|.:|.:.:|:..:|....|::.
  Rat   734 DARRKELA-------KETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKG 791

  Fly   589 QLREISEHL-------------HLALNSSDDIEMLKKCILNGFFENIAVL------QRDGFYITA 634
            |   .:|||             ..|..:||:.:::|..|..|.:..:|.:      :|....:..
  Rat   792 Q---FAEHLLGAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHT 853

  Fly   635 SGNIRSKIHPSS--VLHGKYKPSYILFTEIVQTEQTFLRQVTEIS 677
            ..:....|||.|  |....:..:::::...::|...:|...||:|
  Rat   854 KSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVS 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx36	NP_001101148.1	HrpA	187..893	CDD:224557	192/729 (26%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	257..309		17/51 (33%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	326..329		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79	379..620		60/246 (24%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	490..549		18/63 (29%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1	509..520		2/15 (13%)
		WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79	621..690		20/70 (29%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	630..689		14/60 (23%)
		OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79	833..897		10/63 (16%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	841..852		1/10 (10%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79	862..892		5/29 (17%)
		Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..192		6/28 (21%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000269|PubMed:23651854	1..96
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1	1..43
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1	45..97
		DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1	45..67
		RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79	98..378		73/220 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820