DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and Dhx16

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_997661.1	Gene:	Dhx16 / 294232	RGDID:	1302963	Length:	1044	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	285/707 - (40%)
Similarity:	417/707 - (58%)	Gaps:	39/707 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSKYFATSRNDAVGPSPVKFSFKRKYDAMANSP----ILEKKPHV-----AQIKQTIAP------ 51
            :.:.:..:|.||   :.:||..:   ||.|..|    :||:...:     ||::....|
  Rat   327 EQRRWEEARLDA---ASLKFGAR---DAAAQEPQYQLVLEEDETIEFVRAAQLQGDEEPSSGPPL 385

  Fly    52 ILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGM- 115
            .....::.||:..::|||||..|..:|..:..:..::|..||||||||||||:|...||.|.||
  Rat   386 SAQAQQKESIQAVRRSLPVFPFREELLTAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTKKGMK 450

  Fly   116 IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLL 180
            |..||||||||::||.|||:|:...:|:.|||::||||.||..|.:|::|||:||||.:.:..|.
  Rat   451 IACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERTVLRYMTDGMLLREFLSEPDLA 515

  Fly   181 KYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMY-L 244
            .|||:::|||||||::.|:|||::||..:.|     ..|||:|.|||:|...|..:|:...:: :
  Rat   516 SYSVVMVDEAHERTLHTDILFGLIKDVARFR-----PELKVLVASATLDTARFSAFFDDAPVFRI 575

  Fly   245 EGRTYPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDT 309
            .||.:||.:.:||....||:...:|::..||.|.|.. |:|:|||||||||:..:.::...:...
  Rat   576 PGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQPPG-DILVFLTGQEEIEAACEMLQDRCRRLG 639

  Fly   310 TGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFN 374
            :...:|.|..:||.|....|...|.|||...|||::||||||||:||.||..|:|.||.|:||:|
  Rat   640 SKIRELLVLPIYANLPSDMQARIFQPTPPGARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYN 704

  Fly   375 TVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTK-AEMDSFADATQPEILRTNPTSMVLQ 438
            ...|::.|.....|||.|.||||||||.|.|.|:|.||. |......:.|.|||.||:..::||.
  Rat   705 PRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLL 769

  Fly   439 LLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIK-TGDDSYITPLGRQMVQYPLDPKYSKLL 501
            |.:|.| |..:|||||||..:.|..|.:.|.||||:. .|:   :|..||:|.:.|:||..||::
  Rat   770 LKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGE---LTTSGRKMAELPVDPMLSKMI 831

  Fly   502 LTASSFGCMEEILSLVSVLS-SDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEK 565
            |.:..:.|.||||::.::|| ::.:|....:|...|..|...|....||||.||||:..:.:|..
  Rat   832 LASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLPGGDHLVLLNVYTQWAESGY 896

  Fly   566 PKMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNS-SDDIEMLKKCILNGFFENIAVLQRDG 629
            ...||::|::..||:..||:||.||..:.|.:.:.|.| ..|...::|.|.:|:|.:.|.|.|.|
  Rat   897 SSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLTSCQGDYVRVRKAITSGYFYHTARLTRSG 961

  Fly   630 FYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
             |.|........|||:|.|. :.:|.::|:.|:|.|.:.|:|||.||...|:.||.|
  Rat   962 -YRTVKQQQTVFIHPNSSLF-EQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAP 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx16	NP_997661.1	DEXDc	402..584	CDD:214692	91/186 (49%)
		DEXDc	419..558	CDD:238005	77/143 (54%)
		HELICc	583..740	CDD:238034	70/157 (45%)
		HA2	801..885	CDD:214852	31/86 (36%)
		OB_NTP_bind	920..1018	CDD:285018	36/99 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730