DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and Dhx33

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	293/633 - (46%)
Similarity:	415/633 - (65%)	Gaps:	5/633 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGITQPR 122
            |.::|.|::|||:|..|.::|.:|...|..:::.||||||||||||:|...|.::.|:|.:||||
  Rat    55 REALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPR 119

  Fly   123 RVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIIL 187
            |||||::|.||:.|....:|..||||||||||||..|:|:|||||:||||:|.|.||.|||.:||
  Rat   120 RVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVIL 184

  Fly   188 DEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMYLEGRTYPV 251
            |||||||::.|:|||:||.|||.|::.....|||:|.|||||:|.|..||| ...:|||||.:|:
  Rat   185 DEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPI 249

  Fly   252 RVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLR 316
            ::.:||:..:||:|..||::|.||:..|.:.|:|:|||||||||::::..|.:||....|...:.
  Rat   250 QIFYTKQPQQDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPSML 314

  Fly   317 VFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDV 381
            |..|||.|...:||..|...|...||||::||||||||||.||:.|:|.|.||.|.:|...||:|
  Rat   315 VLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEV 379

  Fly   382 LKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDI-D 445
            |...|:||.|||||.|||||:..|.|||.||:.|.|.|.....|||.|.|..|::|||||:.: :
  Rat   380 LAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFDKFEKMAAPEIQRCNLASVMLQLLAMKVPN 444

  Fly   446 CNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSY-ITPLGRQMVQYPLDPKYSKLLLTASSFGC 509
            ...|||:..|..|.:.:|...||.|||::..||.. :||:||:|..:||:||::|.:|.:|.|.|
  Rat   445 VLTFDFMSRPSPDHIEAAIAQLDLLGALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHC 509

  Fly   510 MEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNY 574
            .||||::||:||.|.|..:...:.:.......||.|..|||:||||::..|......|.||.:|:
  Rat   510 TEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIYRTFKNIGGNKDWCKENF 574

  Fly   575 LNLRSLTYARNVRRQLREISEHLHLALNSS-DDIEMLKKCILNGFFENIAVLQRDGFYITASGNI 638
            :|.:::.....||.|||:|...:.:.:.|| .|:|.:::|:.:..|.:.|.||.||.|.|...:.
  Rat   575 VNSKNMLLVAEVRAQLRDICLKMSMPIMSSRGDMESVRRCLAHSLFMSTAELQPDGTYATTDTHQ 639

  Fly   639 RSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            ...|||||||. ..||:.:::|.::.|.:.::|.:..:..||:.|..|
  Rat   640 PVAIHPSSVLF-HCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	110/196 (56%)
		DEXDc	83..225	CDD:238005	85/141 (60%)
		Helicase_C	282..399	CDD:278689	61/116 (53%)
		HA2	469..554	CDD:214852	36/84 (43%)
		OB_NTP_bind	588..688	CDD:285018	33/100 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339722
Domainoid	1	1.000	179	1.000	Domainoid score	I3441
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56235
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1024
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D136652at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto95929
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5648
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810