DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and prh1

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_593091.1	Gene:	prh1 / 2541750	PomBaseID:	SPAC2G11.11c	Length:	719	Species:	Schizosaccharomyces pombe

Alignment Length:	688	Identity:	281/688 - (40%)
Similarity:	403/688 - (58%)	Gaps:	53/688 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NDAVG---PSPVKFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFN 72
            |:.||   .||.|.|        .|||                     |||..|.:|:|:||::.
pombe    65 NEVVGSDNSSPEKRS--------ENSP---------------------SKRKDILEQRKNLPIWE 100

  Fly    73 CRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGITQPRRVAAITVARRVAQEL 137
            ....:.::::.|..::::.||||||:|||||||....||:.|.:.|||||||||:.:|:|||.|.
pombe   101 AHDTLCQQIQDNRVIVVVGETGSGKSTQIPQFLNECPYAQEGCVAITQPRRVAAVNLAKRVAAEQ 165

  Fly   138 NGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFG 202
            ...:|:.|||::||:|.||:.|:|::||||:||||.|.|.:|.:|..:|||||||||:..|:|.|
pombe   166 GCRLGEQVGYSIRFDDTTSKKTRIKYLTDGMLLRELINDPILSQYHTLILDEAHERTLMTDMLLG 230

  Fly   203 IVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN----CKGMYLEGRTYPVRVMHTKEEHEDY 263
            .||...|:|     ..|:|::.|||::.:.|..:|:    |   |:.||.|||::.:|.....||
pombe   231 FVKKIIKKR-----PALRVIIMSATLNAERFSEFFDGAEIC---YISGRQYPVQIHYTYTPEPDY 287

  Fly   264 IHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLRVFTLYAQLSQGK 328
            :...|.|:|.:|...|.. |:|:|||||:|||:|...|:..:|...:....::...|:|.|.|.:
pombe   288 LDACLRTIFQLHTKLPPG-DILVFLTGQDEIEALEALIKSYSKQLPSNLPQIQACPLFASLPQEQ 351

  Fly   329 QLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRISKAQAW 393
            ||:.|:|..||.|||:|:|||||||:||.|||.|||.|..|.|.||:..||:.|....||::.|.
pombe   352 QLQVFLPALANHRKVVLSTNIAETSVTISGIRYVIDTGLAKIKQFNSKLGLESLTVQPISQSAAM 416

  Fly   394 QRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLAL-DIDCNNFDFLDPPLE 457
            ||:|||||:|.|.|||.||:|:.|.....|.|||.|.:.:..||.|.|. ..|..||.::|||.:
pombe   417 QRSGRAGREAAGQCYRIYTEADFDKLPKETIPEIKRIDLSQAVLTLKARGQNDVINFHYMDPPSK 481

  Fly   458 DGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSS 522
            :||..|.:.|.::||:  .|:.:|..||.||...||.|..::.:|.|....|:.|::.:||.||:
pombe   482 EGLLRALEHLYSIGAL--DDNGHINDLGYQMSLIPLLPSLARAVLAAREHNCLSEVIDVVSCLST 544

  Fly   523 DHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKS--EKPKMWCHDNYLNLRSLTYARN 585
            |.:|:...||.:.|..|..||....||.||.||....:|:|  :..|.||..|::|.|:|....:
pombe   545 DSMFLFPQEKRDEAIEARLKFLHSEGDLLTCLNALRQYLESSHDSRKQWCSQNFINRRALKTILD 609

  Fly   586 VRRQLREISEHLHLALNSSDDI--EMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVL 648
            :|:||||........||||.::  |.|....|:|:..|.|:|..||.|.|..||....|||||.|
pombe   610 IRKQLREHCLKDGWELNSSPEVNSENLLLSFLSGYITNTALLHPDGSYRTIIGNQTISIHPSSSL 674

  Fly   649 HGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            .|| |...|::.|:|.|.::::|.|:.|...|:..|.|
pombe   675 FGK-KVEAIMYHELVFTTKSYVRGVSSIRSNWLNAVAP 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
prh1	NP_593091.1	HrpA	58..711	CDD:224557	280/686 (41%)
		DEXDc	113..251	CDD:238005	73/142 (51%)
		HELICc	276..433	CDD:238034	72/157 (46%)
		HA2	493..576	CDD:214852	31/84 (37%)
		OB_NTP_bind	601..713	CDD:285018	43/112 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7257
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900