DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and cdc28

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_595686.2	Gene:	cdc28 / 2540707	PomBaseID:	SPBC19C2.01	Length:	1055	Species:	Schizosaccharomyces pombe

Alignment Length:	698	Identity:	295/698 - (42%)
Similarity:	428/698 - (61%)	Gaps:	31/698 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKYFATSRNDAVGPSPVKFSF----KRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQ 63
            :|.....:|:.:.|...:|.|    .::.|.:.::.:..:.| |...|.|...:     ..|:|.
pombe   355 NKALLFDQNEWLPPGEKQFDFVFDESQQIDFLLDTKLSAENP-VDTDKMTDVKV-----EKSLES 413

  Fly    64 QQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAK-NGMIGITQPRRVAAI 127
            .:|||||:..:..:||.:.....:||::|||||||||:||||..|||.| |..|..||||||||:
pombe   414 SRKSLPVYQYKDDLLKAINEYQVLLIVAETGSGKTTQLPQFLHEAGYTKGNKKICCTQPRRVAAM 478

  Fly   128 TVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHE 192
            :||.|||:|::..:|..|||::|||:.||..|.|::||||:||||.:.:..|..|||||:|||||
pombe   479 SVAARVAKEMDVRLGQEVGYSIRFENATSEKTVIKYLTDGMLLREFLTEPDLASYSVIIIDEAHE 543

  Fly   193 RTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFN-CKGMYLEGRTYPVRVMHT 256
            ||::.|:|||:|||..:.|     .:|||:::|||:|.:.|..||: ....|:.||.|||.:.:|
pombe   544 RTLHTDILFGLVKDIARFR-----PDLKVLISSATIDAEKFSAYFDEAPVFYVPGRRYPVDIYYT 603

  Fly   257 KEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLRVFTLY 321
            .:...:||...:.|:..||.|.|.. |:|:|||||:|||.:::.:::|.:|......::.:..:|
pombe   604 PQPEANYIQAAITTILQIHTTQPAG-DILVFLTGQDEIELMSENMQELCRILGKRIPEIILCPIY 667

  Fly   322 AQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVR 386
            |.|....|.:.|.|||...|||:||||||||||||.|:..|||.||||:..:|...|::.|.||.
pombe   668 ANLPSELQAKIFDPTPPGARKVVLATNIAETSITIDGVNFVIDSGFVKQNMYNPRTGMESLVSVP 732

  Fly   387 ISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFAD-ATQPEILRTNPTSMVLQLLALDIDCNN-- 448
            .|:|.|.||||||||...|.|:|.||:...::..| .|.|||.|||.|::||.|.:|.|  ||
pombe   733 CSRASADQRAGRAGRVGPGKCFRLYTRRTYNNELDMVTSPEIQRTNLTNIVLLLKSLGI--NNLL 795

  Fly   449 -FDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEE 512
             |||:|.|..:.|..:.:.|.||||:....:  :|.|||||.::|.||..||.|:.:|.:||:||
pombe   796 DFDFMDAPPPETLMRSLELLYALGALNNRGE--LTKLGRQMAEFPTDPMLSKSLIASSKYGCVEE 858

  Fly   513 ILSLVSVL-SSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLN 576
            :||:||:| .:..:|....:|...|..|.|.|....|||||||:::|.::.::....|..:|:|.
pombe   859 VLSIVSMLGEASSLFYRPKDKIMEADKARANFTQPGGDHLTLLHIWNEWVDTDFSYNWARENFLQ 923

  Fly   577 LRSLTYARNVRRQLREISEHLHLAL--NSSDDIEMLKKCILNGFFENIAVLQRDG-FYITASGNI 638
            .:||..||:||.||..:.|.:.:.|  |||:.::.:||.|..|:|.|.|.|.|.| .|.|...|.
pombe   924 YKSLCRARDVRDQLANLCERVEIELVTNSSESLDPIKKAITAGYFSNAARLDRSGDSYRTVKSNQ 988

  Fly   639 RSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            ...|||||.:..| ||..|::.|:|.|.:.:.||:|||..||:.|:.|
pombe   989 TVYIHPSSSVAEK-KPKVIIYFELVLTTKEYCRQITEIQPEWLLEISP 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
cdc28	NP_595686.2	RILP-like	226..>294	CDD:304877
		HrpA	389..1033	CDD:224557	287/660 (43%)
		DEXDc	435..574	CDD:238005	80/143 (56%)
		Helicase_C	615..749	CDD:278689	64/134 (48%)
		HA2	817..901	CDD:214852	37/85 (44%)
		OB_NTP_bind	923..1037	CDD:285018	47/114 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720