DRSC/TRiP Functional Genomics Resources

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Protein Alignment ath and Ythdc2

DIOPT Version :10

Sequence 1:NP_609356.2 Gene:ath / 34357 FlyBaseID:FBgn0032194 Length:694 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:848 Identity:219/848 - (25%)
Similarity:339/848 - (39%) Gaps:279/848 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 QKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGM---IGITQPRRVAA 126
            ::|||||..:..|:|.::.|..|||:.|||||||||||||||...: |||:   |..|||||:||
Mouse   205 RQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCF-KNGIPCRIFCTQPRRLAA 268

  Fly   127 ITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIK-DRLLLKYSVIILDEA 190
            |.||.|||.|....||.|:||.:|.|...|..|.:.|.|:|||||..:. |..|...:.:|:||.
Mouse   269 IAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEV 333

  Fly   191 HERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVM 254
            |||...:|.|...::|.     .||...||::::||.:|::.|..|| :|..:|::||.:.|:.|
Mouse   334 HERDRFSDFLLTKLRDL-----LQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEM 393

  Fly   255 ----------HTKEE-------------------------------------------------- 259
                      :|.:|                                                  
Mouse   394 FLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRAVASVSEEYDLLD 458

  Fly   260 -----------------------------------HED------YIHTVL---VTLFHIHRTTPK 280
                                               |:|      ..|.:|   |::.:.|..|..
Mouse   459 DGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTENVSVDYRHSETSA 523

  Fly   281 ----------------------------------------------------------------- 280
                                                                             
Mouse   524 TALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSASLEFGNLDE 588

  Fly   281 ----------------------NHD--------------------------VLIFLTGQEEIESL 297
                                  :|.                          :||||.|.:||..|
Mouse   589 SSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAILIFLPGYDEIVGL 653

  Fly   298 AQQIRQLAKIDTTGTTDLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCV 362
            ..:|....|.....|...:||.|::.:....|.:.....||.|||:||:|||||||||:..:..|
Mouse   654 RDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFV 718

  Fly   363 IDCGFVKEKSFNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEI 427
            ||.|.||||||:.::.:.:||.|.||||.|.||.|||||...|.|:|.:::....:..:...||:
Mouse   719 IDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPEL 783

  Fly   428 LRTNPTSMVLQLLAL------DIDCNNFDFL----DPPLEDGLRSAYKSLDALGAIKTGDDSYIT 482
            ||     |.||.|.|      .::|...|||    :||....:|:|.:.|..:.|:...:|  :|
Mouse   784 LR-----MPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRNAVQMLKTIDAMDAWED--LT 841

  Fly   483 PLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSSDHVFV--SNSEKNEMAALAHAKFQS 545
            .||..:...|::|...|::|.|....|::.||::...|:....||  :.:.:...|.|...:|.:
Mouse   842 ELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTA 906

  Fly   546 -KHGDHLTLLNVFNGFLKSEK---PKMWCHDNYLNLRSLTYARNVRRQL---------------- 590
             ...||:.||..|..:.|:..   .:.:|..|:|:..::.....:|.||                
Mouse   907 GTFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGG 971

  Fly   591 --REISEHLHLALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYK 653
              |:::       .:|::..::|..::.|.:.|:..:.|:...:|.....:.:.||:|||.   :
Mouse   972 DIRDVN-------TNSENWAVVKAALVAGMYPNLVHVDRENVILTGPKEKKVRFHPTSVLS---Q 1026

  Fly   654 PSY 656
            |.|
Mouse  1027 PQY 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
athNP_609356.2 HrpA 67..>686 CDD:441249 219/846 (26%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50
R3H_DEXH_helicase 61..119 CDD:100077
PRK11131 203..>1033 CDD:182986 219/848 (26%)
DEXHc_YTHDC2 208..383 CDD:350745 81/180 (45%)
DEAH box 331..334 2/2 (100%)
ANK repeat 520..552 CDD:293786 1/31 (3%)
ANK 1 521..553 1/31 (3%)
ANK 2 554..586 0/31 (0%)
ANK repeat 554..582 CDD:293786 0/27 (0%)
SF2_C_RHA 612..767 CDD:350178 60/154 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303
YTH 1304..1433 CDD:410979
Blue background indicates that the domain is not in the aligned region.

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