Protein Alignment ath and DHX30

DIOPT Version :10

• Sequence 1: NP_609356.2
• Gene: ath / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 203/732 - (27%)
• Similarity: 338/732 - (46%)
• Gaps: 145/732 - (19%)

  Fly    34 PILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKT 98
            |:||.:    :::.:.:.:.|..:|..:.|:...|||...|..||..:|.:..|:|..:||.|||
Human   475 PLLEAE----EVRLSQSLLELWRRRGPVWQEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKT 535

  Fly    99 TQIPQFLLLAGYAKNGM-----IGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFED-VTSR 157
            |:||| |||..|...|.     :.||||||::|::||:||:.||..::...||:.||.|. ..||
Human   536 TRIPQ-LLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPSR 599

  Fly   158 ATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVV 222
            ...:.|.|.|:|||:...:..|...|.:|:||.|||.||.|.|..::|..|:..     ..|::|
Human   600 GGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLN-----PALRLV 659

  Fly   223 VTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVMHTKEEHEDYIHTVLVTL-----FHIHRTTPKN 281
            :.|||.|.:.|..|| .|..:.:.|..|||:        |.|:..:|..|     .|.||    :
Human   660 LMSATGDNERFSRYFGGCPVIKVPGFMYPVK--------EHYLEDILAKLGKHQYLHRHR----H 712

  Fly   282 HD---------------------------VLIFLTGQEEIESLAQQIRQLAKIDTTGTTDLR--V 317
            |:                           :|.||.|.:||:.:.|:::     :..|..:.:  :
Human   713 HESEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQ-----EALGMHESKYLI 772

  Fly   318 FTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVL 382
            ..:::.:....|...|...|..|||::||||||||||||..|..|:|.|..||:.::....:..|
Human   773 LPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEERYDLKTKVSCL 837

  Fly   383 KSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQ--------- 438
            ::|.:|:|...||.|||||...|..|..:.::.::.......||||||...::|||
Human   838 ETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQAKIHMPEKT 902

  Fly   439 ---LLALDIDCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKL 500
               .|:..:|..|...:|        .|...|..:|.:...:  |:|.||:::.....||:.:|.
Human   903 AVEFLSKAVDSPNIKAVD--------EAVILLQEIGVLDQRE--YLTTLGQRLAHISTDPRLAKA 957

  Fly   501 LLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEM----AALAHAKFQSKHGDHLTLLNVFNGFL 561
            ::.|:.|.|:..:|.:||.|:.|....|...:.|:    |.|:|    ....|||..:....|:
Human   958 IVLAAIFRCLHPLLVVVSCLTRDPFSSSLQNRAEVDKVKALLSH----DSGSDHLAFVRAVAGW- 1017

  Fly   562 KSEKPKMW----CHDNYLNLRSLTYA---RNVRRQLREISEHLHLAL----------------NS 603
              |:...|    ..:|||. .:|.||   |.:...:::.||:::.|.                ..
Human  1018 --EEVLRWQDRSSRENYLE-ENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLASAQCNEY 1079

  Fly   604 SDDIEMLKKCILNGFFENIAVLQRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFT----EIVQ 664
            |::.|::|..::.|.:.|:..:::        |.:..:        ||:||:.:.:.    .|:.
Human  1080 SEEEELVKGVLMAGLYPNLIQVRQ--------GKVTRQ--------GKFKPNSVTYRTKSGNILL 1128

  Fly   665 TEQTFLRQVTEISIEWI 681
            .:.|..|:.|.:...|:
Human  1129 HKSTINREATRLRSRWL 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ath	NP_609356.2	HrpA	67..>686	CDD:441249	197/699 (28%)
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	173/571 (30%)
		OB_NTP_bind	1086..1173	CDD:400182	13/76 (17%)