DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and Dhx37

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	XP_017176254.1	Gene:	Dhx37 / 208144	MGIID:	3028576	Length:	1161	Species:	Mus musculus

Alignment Length:	811	Identity:	239/811 - (29%)
Similarity:	378/811 - (46%)	Gaps:	154/811 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PSPVKFSFKRKYDAMANSPILEKKPHVAQIKQTIAPILLTSKRTSIEQQQKSLPVFNCRHRILKE 80
            |.|...|...|..|.|..|.:.|.          |..:..::...:::::..||:......|::.
Mouse   206 PPPSGISAPPKTPASAPPPPVAKP----------AVFIPVNRTPEMQEERLKLPILAEEQAIMEA 260

  Fly    81 LEANDTVLIMSETGSGKTTQIPQFLLLAGY-AKNGMIGITQPRRVAAITVARRVAQELNGTIGDT 144
            :..:..|::..|||||||||:||||..||| :::.:||:|:||||||:.:::|||:|:| .....
Mouse   261 VAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSIIGVTEPRRVAAVAMSQRVAKEMN-LSHRV 324

  Fly   145 VGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQK 209
            |.|.:|:|...:..|:|:|:||||||:|..||.|||||.|:|:||||||:|..|:|.|::.....
Mouse   325 VSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYTDILLGLLSRIVA 389

  Fly   210 ERRKQKLANLKVVVTSATMDIDHF---GNYFNCKG--MYLEGRTYPVRVMHTKEEH-EDYIHTVL 268
            .|.|:.|. ||:::.|||:.::.|   ...|....  :.:|.|.:||.|...|... :||.....
Mouse   390 LRAKRHLP-LKLLIMSATLRVEDFTQNQRLFTTPPPVIKVESRQFPVTVHFNKRTPLDDYSGECF 453

  Fly   269 VTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQL----------------------------- 304
            ..:..|||..|.. .:|:|||||.|:.:|.:::|:.
Mouse   454 RKVCKIHRMLPAG-GILVFLTGQAEVHALCRRLRKAFPFRCSQPQEKEEDSAEGMRRFKKSRTRA 517

  Fly   305 -----------------------------AKID------------------------TTGTTDLR 316
                                         |::|                        ...:..|.
Mouse   518 RKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEALGSDLDLDLGDSEANEGEQPDASLPLH 582

  Fly   317 VFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDV 381
            |..||:.|:..||.:.|.|.|...|..::|||:||||:|||||:.|:|||.||::.::.|.|:..
Mouse   583 VLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSS 647

  Fly   382 LKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVLQLLALDID- 445
            .:...:|:|.|.||||||||...|.|||.|:.|....|.....|||.|.....::||:.||.|:
Mouse   648 FRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALSIEK 712

  Fly   446 CNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSY-------------ITPLGRQMVQYPLDPKY 497
            ..||.|..||..:.|.:|.:.|.||||::......             ||.|||.|..:|:.|:|
Mouse   713 VINFPFPTPPSVEALVAAEELLVALGALQAPPKQERMKKLQMSQLSCPITALGRTMSTFPVAPRY 777

  Fly   498 SKLLLTASSFGCMEEILSLVSVLSSDHVF-------VSNSE----KNEMAALAHAKF-------Q 544
            :|:|..:...||:...:::|:.::...:|       .|..|    |...|.:|..|.       .
Mouse   778 AKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPAASEKELAELKGRRARVAQMKRTWAGQGPS 842

  Fly   545 SKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLNLRSLTYARNVRRQL----REISEHLHLALN--- 602
            .|.||.:.||........:.....:|..|.|..:::...|.:|.||    ..:.....|.|:
Mouse   843 LKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTAVNAVCPEAGLFLDPKM 907

  Fly   603 ---SSDDIEMLKKCILNGFFENIA--VLQRD-------GFYITASGNIRSKIHPSSVLHGKYKPS 655
               :...:..|::.:..|..:::|  |...|       ..|.|...:....|||||||. |..|.
Mouse   908 QPPTESQVTYLRQIMAAGLGDHLARRVQSEDLLDPKWKNAYKTPLLDDPVFIHPSSVLF-KELPE 971

  Fly   656 YILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            ::::.|||:|.:.:::.|:.:.|:||..::|
Mouse   972 FVVYQEIVETTKMYMKGVSTVEIQWIPSLLP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
Dhx37	XP_017176254.1	HrpA	236..1009	CDD:224557	230/771 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910