DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and ddx-15

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	274/711 - (38%)
Similarity:	408/711 - (57%)	Gaps:	49/711 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DAVGPSPVKFSFKRKYDAMANSPILEKKPH-------VAQIKQTIAPI---LLTSKRTSIEQQQK 66
            |..|....:.|..|:..:.:.||.....|.       |..:|..|.|.   ..:::..:|.:::.
Worm    10 DGSGRGDRRRSPNRRSRSRSRSPHRRSSPDRKRQIGAVGNMKIQINPYNNQPFSNRYWAIWEKRS 74

  Fly    67 SLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLL----------LAGYAKNGMIGITQP 121
            .|||:..:.:.::.|..|..:.::.||||||||||||:.:          ..|.|:  ::..|||
Worm    75 QLPVWEYKEKFMELLRNNQCITLVGETGSGKTTQIPQWAVEFMKQQQQGQPPGQAR--LVACTQP 137

  Fly   122 RRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVII 186
            |||||::||.|||:|::..:|..|||::||||..|..|.:::.|||:||||::...||.||.|:|
Worm   138 RRVAAMSVATRVAEEMDVVLGQEVGYSIRFEDCISERTVLKYCTDGMLLREAMNSPLLDKYKVLI 202

  Fly   187 LDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYP 250
            ||||||||:..|:|.|::|:..:.|     |::|||:.|||:|...|..|| :|..:.:.|||:|
Worm   203 LDEAHERTLATDILMGLIKEIVRNR-----ADIKVVIMSATLDAGKFQRYFEDCPLLSVPGRTFP 262

  Fly   251 VRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTT-- 313
            |.:..|....:||:...:.|:..||.......|:|:|||||||||...::|.:  :|...|..
Worm   263 VEIFFTPNAEKDYLEAAIRTVIQIHMVEEVEGDILLFLTGQEEIEEACKRIDR--EIQALGADAG 325

  Fly   314 DLRVFTLYAQLSQGKQLECFVPTPAN------VRKVILATNIAETSITIPGIRCVIDCGFVKEKS 372
            .|....||:.|....|...|.|.|.|      .||.:::|||||||:||.|:..|||.||.|:|.
Worm   326 ALSCIPLYSTLPPAAQQRIFEPAPPNRPNGAISRKCVISTNIAETSLTIDGVVFVIDPGFSKQKV 390

  Fly   373 FNTVDGLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDS-FADATQPEILRTNPTSMV 436
            :|....::.|....||||.|.||||||||...|.|:|.||:....| ..|.|.|||||:|..|:|
Worm   391 YNPRIRVESLLVCPISKASAMQRAGRAGRTKPGKCFRLYTETAYGSEMQDQTYPEILRSNLGSVV 455

  Fly   437 LQLLALDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKL 500
            |||..|.. |..:|||:|||..:.|..|.:.|:.|.||  .||..:|.||..|.::||||:.:|:
Worm   456 LQLKKLGTEDLVHFDFMDPPAPETLMRALELLNYLQAI--NDDGELTELGSLMAEFPLDPQLAKM 518

  Fly   501 LLTASSFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEK 565
            |:|::...|..||||:.::||....:|..:|....|..|.|:|....|||||||||::.|.::::
Worm   519 LITSTELNCSNEILSITAMLSVPQCWVRPNEMRTEADEAKARFAHIDGDHLTLLNVYHSFKQNQE 583

  Fly   566 PKMWCHDNYLNLRSLTYARNVRRQLREISEHLHLALNSSD----DIEM-LKKCILNGFFENIAVL 625
            ...||:||::|.|::..|..||.||..:.:..:|...|:|    |..: ::|.::.|||..:|.|
Worm   584 DPQWCYDNFINYRTMKTADTVRTQLSRVMDKYNLRRVSTDFKSRDYYLNIRKALVAGFFMQVAHL 648

  Fly   626 QRDGFYITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            :|.|.|:|...|....:|||:||  .:||.:.|:.|.|.|.:.|:|.||::..||:.::.|
Worm   649 ERSGHYVTVKDNQLVNLHPSTVL--DHKPEWALYNEFVLTTKNFIRTVTDVRPEWLLQIAP 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	15/64 (23%)
		DEXDc	70..266	CDD:214692	86/202 (43%)
		DEXDc	95..239	CDD:238005	70/150 (47%)
		HELICc	327..419	CDD:197757	41/91 (45%)
		HA2	489..572	CDD:214852	34/84 (40%)
		OB_NTP_bind	607..709	CDD:285018	35/103 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830