DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and F52B5.3

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_492260.1	Gene:	F52B5.3 / 172615	WormBaseID:	WBGene00009922	Length:	1425	Species:	Caenorhabditis elegans

Alignment Length:	1003	Identity:	234/1003 - (23%)
Similarity:	373/1003 - (37%)	Gaps:	365/1003 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SRNDAVGPSPVKFSFK--RKYDAMANSPILEKKP-----------------------HVAQIKQT 48
            |::..|...|:..||:  :|.     |..:||.|                       |::. :..
Worm   105 SKSTLVATEPITPSFECLQKL-----SKFVEKHPITREEMDEFLTETQTKQMHTTKGHISD-RMV 163

  Fly    49 IAPILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKN 113
            |.|....||  .:::.:.|||......::||.:.:.:.|:|...||.|||||:|||:|...:..|
Worm   164 IPPKSKCSK--ELQKVRNSLPASKYCDQVLKSISSCNVVIISGGTGCGKTTQVPQFILDEAHENN 226

  Fly   114 G--MIGITQPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKD 176
            .  .:.:|||||:|||::|.|||:|....||.||||.||.:...|..|.:.:.|.|||||....|
Worm   227 KHVRVMVTQPRRIAAISIAERVARERGEPIGRTVGYQVRLDSRRSDDTVLTYCTTGVLLRMLTSD 291

  Fly   177 RLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMD--IDHFGNYFNC 239
            .:....:.|::||.|||.:|.|.|...:::..|.|     .:|||::.|||::  :..|.|||..
Worm   292 PVASGITHIVMDEIHEREINTDYLLIALRECLKMR-----PDLKVILMSATIEGNMQLFSNYFEN 351

  Fly   240 KGM---YLEGRTYPVRVM------------------------HTKEEHEDYIHTV---------- 267
            ..|   .:|.|.:.|:|.                        :.:|:.:|.|..|
Worm   352 HSMDVIRIESRAFDVKVFYLDQILAMTGYQPPESKAFFSTAEYEEEDWKDEIEAVEREEKDKAKQ 416

  Fly   268 ------LVTL------------------------------------------------------- 271
                  |.||
Worm   417 RAADSSLSTLSKPVTKMAANTKRNSPIEEREWTSGPCSTPDGDIIDERAMRQYMNIIGNPDIRPV 481

  Fly   272 --FHIHRTTPKN---HDVLIFLTGQEEIESLAQQIRQ---------------------------- 303
              .....|||.:   :||.......:..::|.||.|:
Worm   482 ITVEFRPTTPNSVFINDVKYTTNPNQSAQALLQQKRERCLMPRGPLTFTCENPASTTKSPPSPTP 546

  Fly   304 -------LAK-------------------------------------------IDTTGTTDLR-- 316
                   |||                                           :|.|..:.||
Worm   547 TLGISSGLAKFTPFGGFGEKQRISTLLEKKFKEELKTALPDRTVYYHPQMNDVVDKTDFSKLRFG 611

  Fly   317 ----------------------------------------------------------------- 316

Worm   612 EKYNLFYGSSSNNSVDYVLLDQVIQYLADSPVFGTILVFLPGYEDIQQMLKAIDCWKNSLKNMKN 676

  Fly   317 --VFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGL 379
              |..|::|::.....:.|...|.:.||:||||||||.||||..:..|:|.|.||||||:....|
Worm   677 VIVLPLHSQMTSINHGDIFKSVPKDTRKIILATNIAEASITIEDVIFVVDTGKVKEKSFDHEAKL 741

  Fly   380 DVLKSVRISKAQAWQRAGRAGRDADGTCYRAYTKAEMDSFADATQPEILRTNPTSMVL--QLLA- 441
            ..|....|:::.|.||:|||||.|:|.|.|.||:.|.:|..:....|:.|.....:.|  :|.|
Worm   742 STLTVKPIARSNADQRSGRAGRVANGYCIRLYTEQEYNSMPETQIAEMKRAAIYDVTLHAKLFAP 806

  Fly   442 --LDIDCNNFDFL----DPPLEDGLRSAYKSLDALGAIKT------------------------- 475
              |.|.    :||    :||.::.:..|...|:.:||..|
Worm   807 KTLKIS----EFLSLAPEPPEKESILQAITFLEQIGAFYTPIKIYDNSGNEEGLKNDEEAENSEN 867

  Fly   476 GDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEILSLVSVLSS--DHVFVSNSEKNEMAAL 538
            .:|..:|.|||.|.:.||||:.|::||...:..|:..|::||::|:|  .:|...:.:::..:.:
Worm   868 PEDPELTDLGRLMARLPLDPQLSRMLLFGLALKCLTPIVNLVALLASREPYVLALSEDRDLQSKM 932

  Fly   539 AHAKFQSKHGDHLTLLNVFNGFL--KSEKPKMWCHDNYLNLRSLTYARNVRRQ-LREI--SEHLH 598
            .....|....|||..:.:.|.|.  .:.:...:|.|::||..::...:..||| |||:  ::.::
Worm   933 KFEMAQQDLSDHLLYIRLCNEFCSKNNSQQNQFCRDHFLNFSTMRMVQGTRRQLLRELVRAKLIN 997

  Fly   599 LALNSSDDIEMLKKCILNGFFENIAVLQ---RDGFY----ITASGNIRSKI----------HPSS 646
            ::.| .|.:.:|.....|.|.:...::|   ..|.|    ::||.:...|:          ||||
Worm   998 ISPN-RDVLTVLTDHHFNQFSQCWPMIQAVIAAGCYPFIGVSASESNLKKVQTFNDKPAFLHPSS 1061

  Fly   647 VLH------GKYKPS----YILFTEIVQ 664
            ::.      ||.:.|    |:.|.|:.|
Worm  1062 MVKKQIVKMGKSEKSPRVEYVAFQEMCQ 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
F52B5.3	NP_492260.1	R3H	21..100	CDD:214647
		DEXDc	189..369	CDD:214692	71/184 (39%)
		DEXDc	198..338	CDD:238005	60/144 (42%)
		eIF3_subunit	393..>470	CDD:285763	7/76 (9%)
		Helicase_C	647..764	CDD:278689	38/116 (33%)
		HA2	869..948	CDD:214852	24/78 (31%)
		OB_NTP_bind	984..1116	CDD:285018	27/107 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810