DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and DHX15

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_001349.2	Gene:	DHX15 / 1665	HGNCID:	2738	Length:	795	Species:	Homo sapiens

Alignment Length:	706	Identity:	278/706 - (39%)
Similarity:	417/706 - (59%)	Gaps:	45/706 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AVGPSPVKFSFKRKYDAMANSPILEKKPHV--------AQIKQTIAP---ILLTSKRTSIEQQQK 66
            :.|..|:|.|........|:|.......|.        ..:.|.|.|   :..|.:...|.:::.
Human    71 SAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLPQCINPFTNLPHTPRYYDILKKRL 135

  Fly    67 SLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLL-----LAGYAKNGMIGITQPRRVAA 126
            .|||:..:.|....|..:.:.:::.||||||||||||:.:     |.| .|.| :..||||||||
Human   136 QLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPG-PKRG-VACTQPRRVAA 198

  Fly   127 ITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAH 191
            ::||:|||.|::..:|..|||::||||.:|..|.::::|||:||||::.|.||.:|.||||||||
Human   199 MSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAH 263

  Fly   192 ERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYF-NCKGMYLEGRTYPVRVMH 255
            |||:..|:|.|::|:..::|     ::|||:|.|||:|...|..|| ||..:.:.|||:||.:.:
Human   264 ERTLATDILMGVLKEVVRQR-----SDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFY 323

  Fly   256 TKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTG--TTDLRVF 318
            |.|...||:...:.|:..||....:..|:|:||||||||:...::|::  ::|..|  ..|:::.
Human   324 TPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKR--EVDDLGPEVGDIKII 386

  Fly   319 TLYAQLSQGKQLECFVPTP------ANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVD 377
            .||:.|...:|...|.|.|      |..|||:::|||||||:||.|:..|||.||.|:|.:|...
Human   387 PLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRI 451

  Fly   378 GLDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYT-KAEMDSFADATQPEILRTNPTSMVLQLLA 441
            .::.|....||||.|.||||||||...|.|:|.|| ||......|.|.|||||:|..|:||||..
Human   452 RVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKK 516

  Fly   442 LDI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTAS 505
            |.| |..:|||:|||..:.|..|.:.|:.|.|:  .||..:|.||..|.::||||:.:|:::.:.
Human   517 LGIDDLVHFDFMDPPAPETLMRALELLNYLAAL--NDDGDLTELGSMMAEFPLDPQLAKMVIASC 579

  Fly   506 SFGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWC 570
            .:.|..|:||:.::||....||..:|..:.|..|..:|....|||||||||::.|.::.:...||
Human   580 DYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWC 644

  Fly   571 HDNYLNLRSLTYARNVRRQLREISEHLHLALNSSDDIEM-----LKKCILNGFFENIAVLQRDGF 630
            :||::|.|||..|.|||:||..|.:..:|...|:|....     ::|.::.|:|..:|.|:|.|.
Human   645 YDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGH 709

  Fly   631 YITASGNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP 686
            |:|...|...::|||:||  .:||.::|:.|.|.|.:.::|..|:|..||:.::.|
Human   710 YLTVKDNQVVQLHPSTVL--DHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAP 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
DHX15	NP_001349.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		7/36 (19%)
		HrpA	124..763	CDD:224557	267/651 (41%)
		DEAH box	260..263		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730