DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4901 and DHX8

DIOPT Version :9

Sequence 1:	NP_001334733.1	Gene:	CG4901 / 34357	FlyBaseID:	FBgn0032194	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_004932.1	Gene:	DHX8 / 1659	HGNCID:	2749	Length:	1220	Species:	Homo sapiens

Alignment Length:	646	Identity:	271/646 - (41%)
Similarity:	401/646 - (62%)	Gaps:	17/646 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 KRT--SIEQQQKSLPVFNCRHRILKELEANDTVLIMSETGSGKTTQIPQFLLLAGYAKNGMIGIT 119
            |:|  ||.:|::|||::..:.::::.:..|..::::.||||||||||.|:|..|||...|.||.|
Human   552 KKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCT 616

  Fly   120 QPRRVAAITVARRVAQELNGTIGDTVGYTVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSV 184
            |||||||::||:||::|....:|..||||:||||.||..|.|:::|||:||||.:.|..|.:|::
Human   617 QPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLTQYAI 681

  Fly   185 IILDEAHERTVNADLLFGIVKDAQKERRKQKLANLKVVVTSATMDIDHFGNYFNCKGMY-LEGRT 248
            |:||||||||::.|:|||::|     :..||..::|::|||||:|...|..||....:: :.|||
Human   682 IMLDEAHERTIHTDVLFGLLK-----KTVQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRT 741

  Fly   249 YPVRVMHTKEEHEDYIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEIESLAQQIRQLAKIDTTGTT 313
            |||.:::|||...||:...|:|:..||.|.|.. |:|:||||||||::..:.:.:..|.......
Human   742 YPVEILYTKEPETDYLDASLITVMQIHLTEPPG-DILVFLTGQEEIDTACEILYERMKSLGPDVP 805

  Fly   314 DLRVFTLYAQLSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDG 378
            :|.:..:|:.|....|...|.|.|...|||::||||||||:||.||..|:|.||||:|.:|:..|
Human   806 ELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTG 870

  Fly   379 LDVLKSVRISKAQAWQRAGRAGRDADGTCYRAYT-KAEMDSFADATQPEILRTNPTSMVLQLLAL 442
            :|.|....||:|||.||||||||...|.|||.|| :|..|.......|||.|||..|.||.|.|:
Human   871 IDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAM 935

  Fly   443 DI-DCNNFDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASS 506
            .| |..:|||:|.|..:.|.:|.:.|..|||:  .|:..:|.|||:|.::||:|...|:|:.:..
Human   936 GINDLLSFDFMDAPPMETLITAMEQLYTLGAL--DDEGLLTRLGRRMAEFPLEPMLCKMLIMSVH 998

  Fly   507 FGCMEEILSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCH 571
            .||.||:|::||:||..:||....:|..:|....|||....|||||||.|:|.:..::....||:
Human   999 LGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCY 1063

  Fly   572 DNYLNLRSLTYARNVRRQLREISEHLHL-ALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITAS 635
            :|::..|||..|:::|:|:..|.:...| .::.......::|.|.:|||.|.|.......|.|..
Human  1064 ENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLI 1128

  Fly   636 GNIRSKIHPSSVLHGKYKPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP--FVKNIPTR 694
            ......|||||.|..: :|.::::.|:|.|.:.::|:||.|...|:.|..|  |..:.||:
Human  1129 DQQVVYIHPSSALFNR-QPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTK 1188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4901	NP_001334733.1	None
DHX8	NP_004932.1	GH2-like_DHX8	25..92	CDD:409668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..266
		RpsA	<263..422	CDD:223613
		S1_DHX8_helicase	265..343	CDD:240189
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..372
		HrpA	557..1219	CDD:224557	269/641 (42%)
		DEAH box	685..688		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730