Protein Alignment ath and DQX1

DIOPT Version :10

• Sequence 1: NP_609356.2
• Gene: ath / 34357
• FlyBaseID: FBgn0032194
• Length: 694
• Species: Drosophila melanogaster
• Sequence 2: NP_598376.2
• Gene: DQX1 / 165545
• HGNCID: 20410
• Length: 717
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 210/717 - (29%)
• Similarity: 339/717 - (47%)
• Gaps: 91/717 - (12%)

  Fly    30 MANSPIL---EKKPHVAQIKQTIAP---ILLTSKRTSIEQQQKSLPVFNCRHRILKELEANDT-- 86
            |.:.|:.   |..|...:.:..:.|   :..:|:...:.:|:::||::..|...|::||:|.|
Human     1 MTSQPLRLAEEYGPSPGESELAVNPFDGLPFSSRYYELLKQRQALPIWAARFTFLEQLESNPTGV 65

  Fly    87 VLIMSETGSGKTTQIPQ----FLLLAGYAKNGMIGITQPRRVAAITVARRVAQELNGTIGDTVGY 147
            ||:..|.||||:|||||    |.|..|:.| |.:.:|||..:||.::|.|||.|::.|:|..|||
Human    66 VLVSGEPGSGKSTQIPQWCAEFALARGFQK-GQVTVTQPYPLAARSLALRVADEMDLTLGHEVGY 129

  Fly   148 TVRFEDVTSRATKIRFLTDGVLLRESIKDRLLLKYSVIILDEAHERTVNADLLFGIVKDAQKERR 212
            ::..||.|...|.:||..|.:||:|....|....:.|::||||.||:|.:|.|.|:::||:.|:.
Human   130 SIPQEDCTGPNTLLRFCWDRLLLQEVASTRGTGAWGVLVLDEAQERSVASDSLQGLLQDARLEKL 194

  Fly   213 KQKLANLKVVVTSATMDID---HFGNYFNCKGMYLEGRTYPVRVMHTKEEHE------------D 262
            ...|.  .||||...::..   .:||              |..|...:|..|            |
Human   195 PGDLR--VVVVTDPALEPKLRAFWGN--------------PPIVHIPREPGERPSPIYWDTIPPD 243

  Fly   263 YIHTVLVTLFHIHRTTPKNHDVLIFLTGQEEI----ESLAQQIRQLAKIDTTGTTDLRVFTLYAQ 323
            .:......:..:.|..... |||:||..:|||    |||::::..|.   ..|... ||..|:..
Human   244 RVEAACQAVLELCRKELPG-DVLVFLPSEEEISLCCESLSREVESLL---LQGLPP-RVLPLHPD 303

  Fly   324 LSQGKQLECFVPTPANVRKVILATNIAETSITIPGIRCVIDCGFVKEKSFNTVDGLDVLKSVRIS 388
            ..:..|.   |....:.|||::...:|:.|.::|.|:.|||.|......:|.....:......||
Human   304 CGRAVQA---VYEDMDARKVVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAEFQVLRPIS 365

  Fly   389 KAQAWQRAGRAGRDADGTCYRAYTKAEMDSFA-DATQPEILRTNPTSMVLQLLALDI----DCNN 448
            |.||..|..||.....|:|...|.|:.::..| ...||.:...|.:|:||.|....|    :|:
Human   366 KCQAEARRLRARGFPPGSCLCLYPKSFLELEAPPLPQPRVCEENLSSLVLLLKRRQIAEPGECH- 429

  Fly   449 FDFLDPPLEDGLRSAYKSLDALGAIKTGDDSYITPLGRQMVQYPLDPKYSKLLLTASSFGCMEEI 513
              |||.|..:.|..|.:.||.|.|:  .||..::.||..:.::||.|:.:|.||.:..|.|::|:
Human   430 --FLDQPAPEALMQALEDLDYLAAL--DDDGDLSDLGVILSEFPLAPELAKALLASCEFDCVDEM 490

  Fly   514 LSLVSVLSSDHVFVSNSEKNEMAALAHAKFQSKHGDHLTLLNVFNGFLKSEKPKMWCHDNYLNLR 578
            |:|.::|::...|.......|.|||..| .:...|||.:|:.|:..|::|...:.||....||..
Human   491 LTLAAMLTAAPGFTRPPLSAEEAALRRA-LEHTDGDHSSLIQVYEAFIQSGADEAWCQARGLNWA 554

  Fly   579 SLTYARNVRRQLREISEHLHL-----ALNSSDDIEMLKKCILNGFFENIAVLQRDGFYITASGNI 638
            :|..|..:|.:|.|:.:.:.|     |..|..:...|:|.:::|:|..:|   ||   ...:||.
Human   555 ALCQAHKLRGELLELMQRIELPLSLPAFGSEQNRRDLQKALVSGYFLKVA---RD---TDGTGNY 613

  Fly   639 RSKIHPSSVLHGKY-----------KPSYILFTEIVQTEQTFLRQVTEISIEWIKEVVP--FVKN 690
            ....|........|           .|.::|:.....::...|..|:||..:.:.|:.|  |:.|
Human   614 LLLTHKHVAQLSSYCCYRSRRAPARPPPWVLYHNFTISKDNCLSIVSEIQPQMLVELAPPYFLSN 678

  Fly   691 IP 692
            :|
Human   679 LP 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ath	NP_609356.2	HrpA	67..>686	CDD:441249	199/664 (30%)
DQX1	NP_598376.2	HrpA	44..>615	CDD:441249	190/607 (31%)
		DEXQc_DQX1	45..224	CDD:350744	74/195 (38%)
		DEAQ box. /evidence=ECO:0000305|PubMed:11353393	170..173		2/2 (100%)
		OB_NTP_bind	591..674	CDD:400182	19/88 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..717